DE2258561A1 - Basisch substituierte pyrimidon-(4)derivate, verfahren zu deren herstellung und sie enthaltende arzneimittel - Google Patents
Basisch substituierte pyrimidon-(4)derivate, verfahren zu deren herstellung und sie enthaltende arzneimittelInfo
- Publication number
- DE2258561A1 DE2258561A1 DE19722258561 DE2258561A DE2258561A1 DE 2258561 A1 DE2258561 A1 DE 2258561A1 DE 19722258561 DE19722258561 DE 19722258561 DE 2258561 A DE2258561 A DE 2258561A DE 2258561 A1 DE2258561 A1 DE 2258561A1
- Authority
- DE
- Germany
- Prior art keywords
- group
- carbon atoms
- piperazinyl
- general formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU64387 | 1971-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2258561A1 true DE2258561A1 (de) | 1973-06-20 |
Family
ID=19726894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19722258561 Pending DE2258561A1 (de) | 1971-12-02 | 1972-11-30 | Basisch substituierte pyrimidon-(4)derivate, verfahren zu deren herstellung und sie enthaltende arzneimittel |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS4862774A (me) |
BE (1) | BE792206A (me) |
DD (1) | DD106646A5 (me) |
DE (1) | DE2258561A1 (me) |
FR (1) | FR2162106A1 (me) |
HU (1) | HU164196B (me) |
IL (1) | IL40971A0 (me) |
LU (1) | LU64387A1 (me) |
NL (1) | NL7216309A (me) |
OA (1) | OA04289A (me) |
ZA (1) | ZA728536B (me) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4425143A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
US6214822B1 (en) | 1996-01-12 | 2001-04-10 | Basf Aktiengesellschaft | Substituted aza and diazacycloheptane and cyclooctane compounds and their use |
EP1407774A1 (en) * | 2002-09-10 | 2004-04-14 | LION Bioscience AG | 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds |
WO2005005395A2 (en) * | 2003-07-02 | 2005-01-20 | F. Hoffmann-La Roche Ag | Arylamine-substituted quinazolinone compounds |
WO2006003150A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Substituted 2-alkyl quinazolinone derivatives as parp inhibitors |
FR2877005A1 (fr) * | 2004-10-22 | 2006-04-28 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
WO2006072588A1 (en) * | 2005-01-07 | 2006-07-13 | Laboratorios Del Dr. Esteve S.A. | Substituted 2-amino-quinazolin-4-cn compounds for use in the treatment of cns disorders, pain, stroke, addiction and epilepsy, their preaparation and use as intermediates |
US8168644B2 (en) | 2008-03-27 | 2012-05-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
US8450486B2 (en) | 2003-11-20 | 2013-05-28 | Janssen Pharmaceutica, Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US8524714B2 (en) | 2003-11-20 | 2013-09-03 | Janssen Pharmaceutica, Nv | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US8623884B2 (en) | 2004-06-30 | 2014-01-07 | Janssen Pharmaceutica, Nv | Quinazolinedione derivatives as PARP inhibitors |
US8889866B2 (en) | 2008-03-27 | 2014-11-18 | Janssen Pharmaceutica, Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
US8946221B2 (en) | 2004-06-30 | 2015-02-03 | Janssen Pharmaceutica, Nv | Phthalazine derivatives as PARP inhibitors |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3222914A1 (de) * | 1982-06-18 | 1983-12-22 | Beiersdorf Ag, 2000 Hamburg | Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
IT1153066B (it) * | 1982-11-18 | 1987-01-14 | Mentedison S P A | Derivati del pirimidin-4-one ad attivita' erbicida |
JPS6172764A (ja) * | 1984-09-17 | 1986-04-14 | Hokuriku Seiyaku Co Ltd | キナゾリノン誘導体 |
JPH0696561B2 (ja) * | 1985-08-30 | 1994-11-30 | 正幸 石川 | 新規な2−(4−フエニル−1−ピペラジニルアルキル)アミノピリミジン誘導体及びその酸付加塩 |
HUT76266A (en) * | 1995-10-31 | 1997-07-28 | Egyt Gyogyszervegyeszeti Gyar | New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components |
EP1911754B1 (en) * | 2003-08-13 | 2013-10-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
RU2006107553A (ru) | 2003-08-13 | 2007-09-20 | Такеда Фармасьютикал Компани Лимитед (Jp) | Производные 4-пиримидона и их применение в качестве ингибиторов пептидилпептидаз |
US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EA013427B1 (ru) | 2004-03-15 | 2010-04-30 | Такеда Фармасьютикал Компани Лимитед | Ингибиторы дипептидилпептидазы |
JP2008524331A (ja) | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
ME02005B (me) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Inhibitori dipeptidil peptidaze za lečenje dijabetesa |
CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
CN107226808B (zh) * | 2016-03-23 | 2021-01-01 | 北京四环制药有限公司 | 端锚聚合酶抑制剂 |
-
0
- BE BE792206D patent/BE792206A/xx unknown
-
1971
- 1971-12-02 LU LU64387A patent/LU64387A1/xx unknown
-
1972
- 1972-11-30 DD DD167200A patent/DD106646A5/xx unknown
- 1972-11-30 HU HUBI460A patent/HU164196B/hu unknown
- 1972-11-30 IL IL40971A patent/IL40971A0/xx unknown
- 1972-11-30 OA OA54767A patent/OA04289A/xx unknown
- 1972-11-30 DE DE19722258561 patent/DE2258561A1/de active Pending
- 1972-11-30 FR FR7242607A patent/FR2162106A1/fr not_active Withdrawn
- 1972-12-01 NL NL7216309A patent/NL7216309A/xx unknown
- 1972-12-01 ZA ZA728536A patent/ZA728536B/xx unknown
- 1972-12-02 JP JP47121143A patent/JPS4862774A/ja active Pending
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4425143A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
WO1996002519A1 (de) * | 1994-07-15 | 1996-02-01 | Basf Aktiengesellschaft | Substituierte pyrimidinverbindungen und deren verwendung |
US6342604B1 (en) * | 1994-07-15 | 2002-01-29 | Basf Aktiengesellschaft | Substitute pyrimidine compounds and the use thereof |
US6214822B1 (en) | 1996-01-12 | 2001-04-10 | Basf Aktiengesellschaft | Substituted aza and diazacycloheptane and cyclooctane compounds and their use |
US6352981B1 (en) | 1996-01-12 | 2002-03-05 | Basf Aktiengesellschaft | Substituted AZA- and diazacycloheptane and -cyclooctane |
EP1407774A1 (en) * | 2002-09-10 | 2004-04-14 | LION Bioscience AG | 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds |
KR100802856B1 (ko) | 2003-07-02 | 2008-02-12 | 에프. 호프만-라 로슈 아게 | 아릴아민-치환된 퀴나졸린온 화합물 |
WO2005005395A3 (en) * | 2003-07-02 | 2005-05-06 | Hoffmann La Roche | Arylamine-substituted quinazolinone compounds |
WO2005005395A2 (en) * | 2003-07-02 | 2005-01-20 | F. Hoffmann-La Roche Ag | Arylamine-substituted quinazolinone compounds |
US7244738B2 (en) | 2003-07-02 | 2007-07-17 | Roche Palo Alto Llc | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists |
US8450486B2 (en) | 2003-11-20 | 2013-05-28 | Janssen Pharmaceutica, Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
US8524714B2 (en) | 2003-11-20 | 2013-09-03 | Janssen Pharmaceutica, Nv | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
EA012837B1 (ru) * | 2004-06-30 | 2009-12-30 | Янссен Фармацевтика Н.В. | Производные хиназолинона в качестве ингибиторов parp |
WO2006003146A1 (en) * | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as parp inhibitors |
US9255080B2 (en) | 2004-06-30 | 2016-02-09 | Janssen Pharmaceutica Nv | Quinazolinedione derivatives as PARP inhibitors |
US8946221B2 (en) | 2004-06-30 | 2015-02-03 | Janssen Pharmaceutica, Nv | Phthalazine derivatives as PARP inhibitors |
US8623884B2 (en) | 2004-06-30 | 2014-01-07 | Janssen Pharmaceutica, Nv | Quinazolinedione derivatives as PARP inhibitors |
WO2006003150A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Substituted 2-alkyl quinazolinone derivatives as parp inhibitors |
EP1659112A1 (fr) | 2004-10-22 | 2006-05-24 | Bioprojet | Dérivés d'arylpipérazine comme ligands sélectifs du récepteur D3 de la dopamine |
FR2877005A1 (fr) * | 2004-10-22 | 2006-04-28 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
US7432269B2 (en) | 2004-10-22 | 2008-10-07 | Bioprojet | Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents |
WO2006072588A1 (en) * | 2005-01-07 | 2006-07-13 | Laboratorios Del Dr. Esteve S.A. | Substituted 2-amino-quinazolin-4-cn compounds for use in the treatment of cns disorders, pain, stroke, addiction and epilepsy, their preaparation and use as intermediates |
US8778966B2 (en) | 2007-03-08 | 2014-07-15 | Janssen Pharmaceutica, Nv | Quinolinone derivatives as PARP and tank inhibitors |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
US8889866B2 (en) | 2008-03-27 | 2014-11-18 | Janssen Pharmaceutica, Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
US9150540B2 (en) | 2008-03-27 | 2015-10-06 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
US8168644B2 (en) | 2008-03-27 | 2012-05-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
US9598396B2 (en) | 2008-03-27 | 2017-03-21 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
Also Published As
Publication number | Publication date |
---|---|
IL40971A0 (en) | 1973-01-30 |
DD106646A5 (me) | 1974-06-20 |
OA04289A (fr) | 1979-12-31 |
HU164196B (me) | 1974-01-28 |
NL7216309A (me) | 1973-06-05 |
BE792206A (me) | 1973-06-01 |
LU64387A1 (me) | 1973-07-16 |
JPS4862774A (me) | 1973-09-01 |
FR2162106A1 (en) | 1973-07-13 |
ZA728536B (en) | 1973-09-26 |
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