DE2246380C2 - Vorrichtung zum Trennen bzw. Sortieren von Teilchen - Google Patents

Vorrichtung zum Trennen bzw. Sortieren von Teilchen

Info

Publication number
DE2246380C2
DE2246380C2 DE2246380A DE2246380A DE2246380C2 DE 2246380 C2 DE2246380 C2 DE 2246380C2 DE 2246380 A DE2246380 A DE 2246380A DE 2246380 A DE2246380 A DE 2246380A DE 2246380 C2 DE2246380 C2 DE 2246380C2
Authority
DE
Germany
Prior art keywords
pulse
particles
nozzle
liquid
modulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2246380A
Other languages
German (de)
English (en)
Other versions
DE2246380A1 (de
Inventor
William A. La Honda Calif. Bonner
Henry R. Palo Alto Calif. Hulett
Richard G. Sweet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of DE2246380A1 publication Critical patent/DE2246380A1/de
Application granted granted Critical
Publication of DE2246380C2 publication Critical patent/DE2246380C2/de
Expired legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B07SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07CPOSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/34Sorting according to other particular properties
    • B07C5/342Sorting according to other particular properties according to optical properties, e.g. colour
    • B07C5/3425Sorting according to other particular properties according to optical properties, e.g. colour of granular material, e.g. ore particles, grain
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B07SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07CPOSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/36Sorting apparatus characterised by the means used for distribution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04Cell isolation or sorting
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1406Control of droplet point

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
DE2246380A 1972-05-22 1972-09-21 Vorrichtung zum Trennen bzw. Sortieren von Teilchen Expired DE2246380C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00255443A US3826364A (en) 1972-05-22 1972-05-22 Particle sorting method and apparatus

Publications (2)

Publication Number Publication Date
DE2246380A1 DE2246380A1 (de) 1973-12-20
DE2246380C2 true DE2246380C2 (de) 1982-11-04

Family

ID=22968350

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2246380A Expired DE2246380C2 (de) 1972-05-22 1972-09-21 Vorrichtung zum Trennen bzw. Sortieren von Teilchen

Country Status (4)

Country Link
US (1) US3826364A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS49109093A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA974193A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2246380C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US3976197A (en) * 1974-11-22 1976-08-24 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring
JPS5319891A (en) * 1976-06-10 1978-02-23 Coulter Electronics Method and apparatus for folling drop formation and separation
US4097373A (en) * 1977-03-23 1978-06-27 John Caldwell Allred High speed particle sorter using a field emission electrode
DE2716095C2 (de) * 1977-04-12 1987-02-19 Becton, Dickinson and Co., Paramus, N.J. Verfahren zur Steuerung der Bewegungsbahn von in einem Elektrolyten suspendierten Teilchen und Vorrichtung zur Durchführung dieses Verfahrens
DE2732272C2 (de) * 1977-07-16 1979-07-05 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg Verfahren und Vorrichtung zur Fluoreszenzanalyse von gefärbten Partikeln, insbesondere biologischen Zellen
US4230558A (en) * 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4347935A (en) * 1979-05-16 1982-09-07 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for electrostatically sorting biological cells
US4279345A (en) * 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4367043A (en) * 1980-05-05 1983-01-04 Leland Stanford Junior University Method and means for delivering liquid samples to a sample scanning device
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4667830A (en) * 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US4498766A (en) * 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
CH651930A5 (en) * 1983-03-24 1985-10-15 Coulter Corp Apparatus for analysis and sorting of particles
US4599307A (en) * 1983-07-18 1986-07-08 Becton, Dickinson And Company Method for elimination of selected cell populations in analytic cytology
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US4545677A (en) * 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
ATE48477T1 (de) * 1984-09-11 1989-12-15 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
GB8425273D0 (en) * 1984-10-05 1984-11-14 Spandrel Etab Signal responsive to parameter of objects
JPH0336914Y2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1985-05-17 1991-08-05
US4989977A (en) * 1985-07-29 1991-02-05 Becton, Dickinson And Company Flow cytometry apparatus with improved light beam adjustment
JPS62126326A (ja) * 1985-11-26 1987-06-08 Rion Co Ltd 粒子計測方法
US4701664A (en) * 1986-01-09 1987-10-20 Becton, Dickinson And Company Mercury arc lamp suitable for inclusion in a flow cytometry apparatus
US4710635A (en) * 1986-04-14 1987-12-01 Becton, Dickinson And Company Dual laser excitation from single laser source
US4745285A (en) * 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4987539A (en) * 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US5064616A (en) * 1987-11-30 1991-11-12 Becton Dickinson And Company Kit for analysis of subsets of subpopulations of leukocytes
US5123731A (en) * 1988-02-01 1992-06-23 Canon Kabushiki Kaisha Particle measuring device
US5057413A (en) * 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid
US5098849A (en) * 1988-07-13 1992-03-24 Becton Dickinson And Company Material and method to reduce non-specific binding of a labelled material
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
US4981580A (en) * 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
US5156951A (en) * 1989-07-13 1992-10-20 Becton Dickinson And Company Detecting immunological changes in HIV infected patient samples
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
EP0422616B1 (en) * 1989-10-11 1996-02-07 Canon Kabushiki Kaisha Apparatus for and method of fractionating particle in particle-suspended liquid in conformity with the properties thereof
US5108904A (en) * 1990-03-26 1992-04-28 Alan Landay CD44 as a marker for HIV infection
US5224058A (en) * 1990-05-01 1993-06-29 Becton, Dickinson And Company Method for data transformation
US5062532A (en) * 1990-05-07 1991-11-05 Esm International, Inc. Sorting machine including photo site processing
US5076472A (en) * 1990-06-13 1991-12-31 Becton, Dickinson And Company Cleaning cycle for flow cytometers
US5087295A (en) * 1990-06-13 1992-02-11 Becton Dickinson And Company Cleaning cycle for flow cytometers
JP3121849B2 (ja) * 1991-02-27 2001-01-09 シスメックス株式会社 フローイメージサイトメータ
JP3084296B2 (ja) * 1991-02-27 2000-09-04 シスメックス株式会社 フローイメージサイトメータ
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
JP3130628B2 (ja) * 1992-01-30 2001-01-31 シスメックス株式会社 粒子判定装置
US5232828A (en) * 1992-03-09 1993-08-03 Becton, Dickinson And Company Coating agents for cell recovery
ATE237129T1 (de) * 1994-09-02 2003-04-15 Bd Biosciences Systems And Rea Verfahren und vorrichtung zur eichung eines optischen abtasters
US5700692A (en) * 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
US5602349A (en) * 1994-10-14 1997-02-11 The University Of Washington Sample introduction system for a flow cytometer
US5602039A (en) * 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
US6861265B1 (en) * 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
WO1996012171A2 (en) * 1994-10-14 1996-04-25 University Of Washington High speed flow cytometer droplet formation system
JP3347495B2 (ja) * 1994-11-14 2002-11-20 シスメックス株式会社 粒子分析装置
GB2316081B (en) * 1996-08-12 2001-05-09 Bio Dot Ltd Dispensing of particles
US5915925A (en) * 1997-01-07 1999-06-29 North, Jr.; Howard L. Pulseless liquid supply system for flow cytometry
EP2264427B1 (en) 1997-01-31 2017-05-03 Xy, Llc Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis
GB9707096D0 (en) * 1997-04-08 1997-05-28 Smithkline Beecham Plc Novel device
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6281018B1 (en) 1998-02-26 2001-08-28 Coulter International Corp. Selective purification and enrichment sorting of flow cytometer droplets based upon analysis of droplet precursor regions
US6248590B1 (en) * 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
US6079836A (en) * 1998-07-20 2000-06-27 Coulter International Corp. Flow cytometer droplet break-off location adjustment mechanism
EP2283848A1 (en) 1998-07-30 2011-02-16 Xy, Llc Equine system for non-surgical articificial insemination
US7024316B1 (en) * 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
EP2258174A3 (en) 2000-05-09 2012-06-13 Xy, Llc High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
US6549275B1 (en) * 2000-08-02 2003-04-15 Honeywell International Inc. Optical detection system for flow cytometry
US6864970B1 (en) * 2000-10-11 2005-03-08 Best N.V. Apparatus and method for scanning products with a light beam to detect and remove impurities or irregularities in a conveyed stream of the products
US7083945B1 (en) 2000-10-27 2006-08-01 The Board Of Regents Of The University Of Texas System Isolation of binding proteins with high affinity to ligands
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2440181A1 (en) * 2000-12-15 2002-07-25 Dakocytomation Denmark A/S Electrical conductive containment system
SI2371854T1 (sl) 2001-03-09 2014-09-30 Board Of Regents, The University Of Texas System Office Of The General Counsel Induciranje imunosti tumorja z variantami beljakovine, ki se veĺ˝e na folat
ES2405320T3 (es) 2001-05-17 2013-05-30 Beckman Coulter, Inc. Citómetro de flujo con un sistema de alienación óptica automatizado activo
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CN1674780A (zh) 2002-08-01 2005-09-28 Xy公司 低压精子分离系统
MXPA05001654A (es) 2002-08-15 2005-10-18 Xy Inc Citometro de flujo de alta resolucion.
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP2305172B1 (en) 2003-03-28 2016-05-11 Inguran, LLC Apparatus and methods for providing sex-sorted animal sperm
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
JP2005030831A (ja) * 2003-07-09 2005-02-03 Aisin Seiki Co Ltd セルソータ用光照射装置
KR101166180B1 (ko) * 2003-08-13 2012-07-18 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
EP1676122A2 (en) * 2003-09-30 2006-07-05 Singulex, Inc. Methods for enhancing the analysis of particle detection
US20080248562A1 (en) * 2004-01-23 2008-10-09 Tadashi Sano Microorganism Separation Device
EP1730266A2 (en) 2004-03-29 2006-12-13 Monsanto Technology, LLC Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
US7232687B2 (en) * 2004-04-07 2007-06-19 Beckman Coulter, Inc. Multiple sorter monitor and control subsystem for flow cytometer
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
BRPI0513685A (pt) 2004-07-22 2008-05-13 Monsanto Technology Llc processo para enriquecimento de uma população de células de esperma
DK2884258T3 (da) 2004-07-27 2017-01-02 Beckman Coulter Inc Forbedring af flowcytometrisk diskrimination med computerimplementeret geometrisk transformation
US7430046B2 (en) * 2004-07-30 2008-09-30 Biovigilant Systems, Inc. Pathogen and particle detector system and method
US7392908B2 (en) * 2005-01-12 2008-07-01 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
KR101283071B1 (ko) * 2005-07-15 2013-07-05 바이오비질런트 시스템즈 인코포레이티드 병원체 및 입자 검출기 시스템 및 방법
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US7935948B2 (en) * 2006-08-11 2011-05-03 Sokudo Co., Ltd. Method and apparatus for monitoring and control of suck back level in a photoresist dispense system
WO2008067589A1 (en) * 2006-12-04 2008-06-12 The University Of Queensland A particle sorting apparatus and method
WO2008137475A2 (en) 2007-05-01 2008-11-13 Research Development Foundation Immunoglobulin fc libraries
US7880108B2 (en) * 2007-10-26 2011-02-01 Becton, Dickinson And Company Deflection plate
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
US9594071B2 (en) * 2007-12-21 2017-03-14 Colin G. Hebert Device and method for laser analysis and separation (LAS) of particles
WO2010022019A1 (en) 2008-08-21 2010-02-25 Siemens Healthcare Diagnostics Inc. Multi-layer slides for analysis of urine sediments
JP5382852B2 (ja) 2009-02-06 2014-01-08 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
JP5857357B2 (ja) 2010-01-15 2016-02-10 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたセルソーター
US9074977B2 (en) 2010-05-07 2015-07-07 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
US8830451B1 (en) * 2010-05-07 2014-09-09 Stc.Unm Multinode acoustic focusing for parallel flow cytometry analysis applications
GB2484930B (en) * 2010-10-26 2017-04-26 Uh Ventures Ltd An improved low cost apparatus and method for the detection of a fluid-borne particle
WO2012109133A1 (en) 2011-02-07 2012-08-16 Research Development Foundation Engineered immunoglobulin fc polypeptides
AU2012249264B2 (en) 2011-04-29 2017-08-10 Baylor College Of Medicine Ureaplasma vaccine and anitibody for prevention and treatment of human, animal and cell culture infection
US10723497B2 (en) * 2014-11-03 2020-07-28 Vanrx Pharmasystems Inc. Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment
EP2732395B1 (en) * 2011-08-25 2018-04-04 Sony Corporation Compensation of motion-related error in a stream of moving mirco-entities
AU2012309824A1 (en) 2011-09-12 2013-04-18 Abbvie Biotherapeutics Inc. Artificial NK cells and uses thereof
DE102011054659A1 (de) * 2011-10-20 2013-04-25 AeroMegt GmbH Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom
JP6196241B2 (ja) 2012-02-02 2017-09-13 インベンラ, インコーポレイテッド 生物学的に活性なポリペプチドのハイスループットスクリーニング
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
US9087371B2 (en) 2012-03-30 2015-07-21 Sony Corporation Microparticle sorting device and method of optimizing fluid stream therein
EP2861957B1 (en) 2012-06-14 2018-05-09 Bio-rad Laboratories, Inc. Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
US8654329B2 (en) * 2012-06-19 2014-02-18 The United States Of America, As Represented By The Secretary Of The Navy Parallel multisensor optical particle sensors for flowing fluid systems
US8582100B1 (en) * 2012-06-19 2013-11-12 The United States Of America, As Represented By The Secretary Of The Navy Remote multisensor optical particle monitor for flowing fluid systems
EP2864849B1 (en) 2012-06-22 2020-09-02 Bio-Rad Laboratories, Inc. Fluid mixing and rinsing system for a flow cytometer
JP6065527B2 (ja) * 2012-11-08 2017-01-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取方法
EP2950079B1 (en) 2013-01-28 2021-06-16 Sony Corporation Fine particle fractionation device, fine particle fractionation method and program
CN105659069B (zh) 2013-10-16 2019-11-26 索尼公司 颗粒分取设备、颗粒分取方法与程序
JP2015094737A (ja) * 2013-11-14 2015-05-18 ソニー株式会社 光照射装置、粒子分析装置および光照射方法
EP3690424B1 (en) 2014-02-13 2023-12-27 Sony Group Corporation Particle sorting device, particle sorting method, and program
US10302565B2 (en) * 2014-02-19 2019-05-28 Arizona Board Of Regents On Behalf Of Arizona State University System and method for isotopic analysis of calcium using laser induced fluorescence
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
CA2964467A1 (en) 2014-10-14 2016-04-21 Research Development Foundation Methods for generating engineered enzymes
US10457737B2 (en) 2015-02-09 2019-10-29 Research Development Foundation Engineered immunoglobulin Fc polypeptides displaying improved complement activation
CN107532990B (zh) 2015-05-12 2021-11-12 芯片生物技术株式会社 单一粒子解析方法及用于该解析的系统
US10526408B2 (en) 2015-08-28 2020-01-07 Research Development Foundation Engineered antibody FC variants
WO2017068822A1 (ja) 2015-10-19 2017-04-27 ソニー株式会社 画像処理装置、微小粒子分取装置及び画像処理方法
CN108474727B (zh) * 2015-12-23 2021-10-01 西门子保健有限责任公司 用于分析在待检测液体中的颗粒的流动室
MX2019002911A (es) * 2016-09-13 2019-07-18 Basf Coatings Gmbh Sensor para una medicion virtualmente simultanea de una transmision y/o dispersion hacia adelante y/o remision y para una medicion simultanea de la transmision y dispersion hacia adelante o transmision y remision de una muestra liquida.
WO2018052137A1 (ja) 2016-09-16 2018-03-22 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
US10605716B2 (en) * 2017-07-21 2020-03-31 Ricoh Company, Ltd. Particle counting apparatus, particle counting method, and particle containing sample
US10780706B2 (en) * 2018-03-16 2020-09-22 Ricoh Company, Ltd. Discharging device and discharging method
DE102018210015B4 (de) * 2018-06-20 2020-04-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Sortierung von pulverförmigem, partikelförmigem, granulatförmigem oder stückförmigem Material
BR112021000339A2 (pt) * 2018-07-10 2021-04-06 Gerrit Jan Van Den Engh Sistema, aparelho e método para iluminação fora do eixo em citometria de fluxo
US11035776B2 (en) * 2018-10-30 2021-06-15 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
DE102019215692B4 (de) * 2019-10-11 2021-06-17 Gunther Krieg Vorrichtung und Verfahren zur Identifikation von Stoffen in der Fluidzusammensetzung
US11376320B2 (en) 2020-03-05 2022-07-05 Iowa State University Research Foundation, Inc. Immunogenic and vaccine compositions against SARS-CoV-2
WO2022209859A1 (ja) * 2021-03-30 2022-10-06 ソニーグループ株式会社 粒子分析装置及び粒子分析方法
CN119546338A (zh) 2022-06-10 2025-02-28 研究发展基金会 经改造FcRIIB选择性IgG1 Fc变体及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2948470A (en) * 1957-03-15 1960-08-09 Du Mont Allen B Lab Inc Particle counter
US3011634A (en) * 1958-03-03 1961-12-05 K & H Equipment Ltd Method and apparatus for sorting materials
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
US3675768A (en) * 1969-03-17 1972-07-11 Gildardo Legorreta Sanchez Method and apparatus for classifying and segregating particles with electrical and optical means
US3669542A (en) * 1969-10-09 1972-06-13 Coulter Electronics Liquid borne particle sensor
US3661460A (en) * 1970-08-28 1972-05-09 Technicon Instr Method and apparatus for optical analysis of the contents of a sheathed stream
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques

Also Published As

Publication number Publication date
JPS49109093A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-10-17
CA974193A (en) 1975-09-09
DE2246380A1 (de) 1973-12-20
US3826364B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-09-25
US3826364A (en) 1974-07-30

Similar Documents

Publication Publication Date Title
DE2246380C2 (de) Vorrichtung zum Trennen bzw. Sortieren von Teilchen
DE2261695C2 (de) Vorrichtung zur Schnellanalyse und zum Sortieren kleiner Teilchen
DE2929170C2 (de) Meßeinrichtung zur Ermittlung des Fluoreszenz-Emissionsspektrums von Partikeln
DE10304653B4 (de) Mehrparametrige Detektion in einem fluidischen Mikrosystem
DE69031640T2 (de) Verfahren und Gerät zum Sortieren von Teilchen mit einem beweglichen Auffangrohr
DE69530851T2 (de) Monitorvorrichtung für den strahl eines durchflusszytometers
EP1335198B1 (de) Mikrofluidisches Bauelement und Verfahren für die Sortierung von Partikeln in einem Fluid
DE69628389T2 (de) Apparat zur Behandlung von Teilchen durch akustische Strahlung
DE2348724C3 (de) Vorrichtung zum Synchronisieren der Tröpfchenbildung mit der Tröpfchenaufladung in einem Tintenstrahldrucker
EP0756703B1 (de) Vorrichtung zur messung der lichtstreuung an partikeln
DE3500247A1 (de) Vorrichtung zum eliminieren der hintergrundstoerung bei fluoreszenzmessungen
DE2715118C2 (de) Verfahren und Vorrichtung zur Bestimmung des Ölgehalts von mit Öl nicht mischbaren Flüssigkeiten
DE3310551C2 (de) Teilchenuntersuchungsvorrichtung zur Untersuchung von in einer Flüssigkeit suspendierten Teilchen
DE2543124A1 (de) Verfahren zur unterscheidung zwischen diskreten teilchen sowie vorrichtung zur durchfuehrung des verfahrens
DE1958101B2 (de) Verfahren und Vorrichtung zur ' qualitativen Bestimmung von in einem Trägermedium enthaltenen mikroskopischen Teilchen
DE2551026C3 (de) Verfahren zur Analysieren von Teilchen
DE112011101917T5 (de) Verfahren zur Aufbereitung von Mineralen nach ihren Lumineszenzeigenschaften
DE4030344C3 (de) Verfahren und Vorrichtung zum Sortieren von vereinzelbaren, kleineren Gegenständen, insbesondere Früchten aller Art
DE102004017474A1 (de) Messeinrichtung zur Impedanzspektroskopie und zugehöriges Messverfahren
DE2421824A1 (de) Verfahren und vorrichtung zur feststellung der mittelamplitude von impulsen bei der teilchenuntersuchung
DE2748564A1 (de) Verfahren und vorrichtung zur messung von in einer suspension befindlichen teilchen
DE69214471T2 (de) Vorrichtung und Verfahren zum Messen einer Probe
EP0286720A2 (de) Verfahren zur Messung von Strömungsvektoren in Gasströmungen
DE2701523A1 (de) Verfahren und vorrichtung zur zaehlung und klassifizierung von teilchen
DE102010016801A1 (de) Fluoreszenz-Detektionseinheit für eine Flüssigchromatographie-Einrichtung

Legal Events

Date Code Title Description
OD Request for examination
8126 Change of the secondary classification

Ipc: G01N 33/48

D2 Grant after examination