DE2226267B2 - Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittel - Google Patents
Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittelInfo
- Publication number
- DE2226267B2 DE2226267B2 DE19722226267 DE2226267A DE2226267B2 DE 2226267 B2 DE2226267 B2 DE 2226267B2 DE 19722226267 DE19722226267 DE 19722226267 DE 2226267 A DE2226267 A DE 2226267A DE 2226267 B2 DE2226267 B2 DE 2226267B2
- Authority
- DE
- Germany
- Prior art keywords
- complex compound
- asparaginate
- iii
- cerium
- zinc ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims description 9
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 title claims description 3
- 238000000034 method Methods 0.000 title claims 3
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title description 2
- 229940126601 medicinal product Drugs 0.000 title 1
- GWXLDORMOJMVQZ-UHFFFAOYSA-N cerium Chemical compound [Ce] GWXLDORMOJMVQZ-UHFFFAOYSA-N 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 229910052684 Cerium Inorganic materials 0.000 claims description 4
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 150000003751 zinc Chemical class 0.000 claims description 2
- DWHMPBALQYTJFJ-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CC(O)=O DWHMPBALQYTJFJ-DKWTVANSSA-N 0.000 claims 1
- KMKLUVYHNKQOSE-UHFFFAOYSA-N [Ce+2] Chemical class [Ce+2] KMKLUVYHNKQOSE-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- XQTIWNLDFPPCIU-UHFFFAOYSA-N cerium(3+) Chemical compound [Ce+3] XQTIWNLDFPPCIU-UHFFFAOYSA-N 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 150000000703 Cerium Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- ICGOZJYHBAHKNX-UHFFFAOYSA-N carbonic acid pentahydrate Chemical compound C(O)(O)=O.O.O.O.O.O ICGOZJYHBAHKNX-UHFFFAOYSA-N 0.000 description 1
- GHLITDDQOMIBFS-UHFFFAOYSA-H cerium(3+);tricarbonate Chemical compound [Ce+3].[Ce+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GHLITDDQOMIBFS-UHFFFAOYSA-H 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722226267 DE2226267B2 (de) | 1972-05-30 | 1972-05-30 | Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| CH724873A CH575381A5 (US06566495-20030520-M00011.png) | 1972-05-30 | 1973-05-22 | |
| JP5988473A JPS536206B2 (US06566495-20030520-M00011.png) | 1972-05-30 | 1973-05-30 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722226267 DE2226267B2 (de) | 1972-05-30 | 1972-05-30 | Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2226267A1 DE2226267A1 (de) | 1973-12-13 |
| DE2226267B2 true DE2226267B2 (de) | 1977-06-02 |
Family
ID=5846319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19722226267 Granted DE2226267B2 (de) | 1972-05-30 | 1972-05-30 | Komplexverbindung aus asparaginat-, cer(iii)- und zink-ionen, verfahren zu deren herstellung und diese enthaltende arzneimittel |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS536206B2 (US06566495-20030520-M00011.png) |
| CH (1) | CH575381A5 (US06566495-20030520-M00011.png) |
| DE (1) | DE2226267B2 (US06566495-20030520-M00011.png) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4606978A (en) * | 1982-09-24 | 1986-08-19 | Gte Products Corporation | Ductile brazing alloy foil containing reactive metals and precious metals |
| US4690876A (en) * | 1984-11-16 | 1987-09-01 | Gte Products Corporation | Article comprising a ductile brazing alloy foil containing reactive metals and precious metals |
| US4599152A (en) * | 1985-05-24 | 1986-07-08 | Albion Laboratories | Pure amino acid chelates |
| CH678949A5 (US06566495-20030520-M00011.png) * | 1989-06-27 | 1991-11-29 | Muller Ludwig Sa | |
| JP2001220348A (ja) * | 1999-11-30 | 2001-08-14 | Japan Science & Technology Corp | 亜鉛（ｉｉ）有機錯体からなる血糖降下剤 |
| JP2003040784A (ja) * | 2001-01-31 | 2003-02-13 | Japan Science & Technology Corp | 血糖降下剤 |
-
1972
- 1972-05-30 DE DE19722226267 patent/DE2226267B2/de active Granted
-
1973
- 1973-05-22 CH CH724873A patent/CH575381A5/xx not_active IP Right Cessation
- 1973-05-30 JP JP5988473A patent/JPS536206B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4948813A (US06566495-20030520-M00011.png) | 1974-05-11 |
| CH575381A5 (US06566495-20030520-M00011.png) | 1976-05-14 |
| DE2226267A1 (de) | 1973-12-13 |
| JPS536206B2 (US06566495-20030520-M00011.png) | 1978-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |