DE2218288A1 - Verfahren zur reinigung von l-dopa - Google Patents
Verfahren zur reinigung von l-dopaInfo
- Publication number
- DE2218288A1 DE2218288A1 DE2218288A DE2218288A DE2218288A1 DE 2218288 A1 DE2218288 A1 DE 2218288A1 DE 2218288 A DE2218288 A DE 2218288A DE 2218288 A DE2218288 A DE 2218288A DE 2218288 A1 DE2218288 A1 DE 2218288A1
- Authority
- DE
- Germany
- Prior art keywords
- dopa
- treatment
- pepsin
- papain
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title claims abstract description 27
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 9
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 9
- 102000057297 Pepsin A Human genes 0.000 claims abstract description 14
- 108090000284 Pepsin A Proteins 0.000 claims abstract description 14
- 108090000526 Papain Proteins 0.000 claims abstract description 13
- 239000004365 Protease Substances 0.000 claims abstract description 13
- 229940055729 papain Drugs 0.000 claims abstract description 13
- 235000019834 papain Nutrition 0.000 claims abstract description 13
- 229940111202 pepsin Drugs 0.000 claims abstract description 13
- 229940088598 enzyme Drugs 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 11
- 238000004140 cleaning Methods 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 244000046095 Psophocarpus tetragonolobus Species 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 23
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 description 1
- 235000003276 Apios tuberosa Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 244000170226 Voandzeia subterranea Species 0.000 description 1
- 235000013030 Voandzeia subterranea Nutrition 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012045 crude solution Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000007924 ground bean Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2218288A DE2218288A1 (de) | 1972-04-15 | 1972-04-15 | Verfahren zur reinigung von l-dopa |
| BR732611A BR7302611D0 (pt) | 1972-04-15 | 1973-04-11 | Processo para a purificacao de popa |
| ZA732578A ZA732578B (en) | 1972-04-15 | 1973-04-13 | Process for the purification of l-dopa |
| JP48041847A JPS4914613A (enrdf_load_stackoverflow) | 1972-04-15 | 1973-04-14 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2218288A DE2218288A1 (de) | 1972-04-15 | 1972-04-15 | Verfahren zur reinigung von l-dopa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2218288A1 true DE2218288A1 (de) | 1973-10-31 |
Family
ID=5842057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2218288A Pending DE2218288A1 (de) | 1972-04-15 | 1972-04-15 | Verfahren zur reinigung von l-dopa |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS4914613A (enrdf_load_stackoverflow) |
| BR (1) | BR7302611D0 (enrdf_load_stackoverflow) |
| DE (1) | DE2218288A1 (enrdf_load_stackoverflow) |
| ZA (1) | ZA732578B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109232288A (zh) * | 2018-09-27 | 2019-01-18 | 那坡康正天然植物提取有限责任公司 | 一种藜豆生产左旋多巴的方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62120979A (ja) * | 1985-11-19 | 1987-06-02 | Japan Steel Works Ltd:The | 電着式砥石の製造方法及びその装置 |
| JPH0179558U (enrdf_load_stackoverflow) * | 1988-10-28 | 1989-05-29 | ||
| US5388374A (en) * | 1992-10-09 | 1995-02-14 | United States Surgical Corporation | Apparatus and method for grinding points |
| JP3992168B2 (ja) * | 1998-09-17 | 2007-10-17 | 株式会社ディスコ | 電着ブレードの製造方法 |
-
1972
- 1972-04-15 DE DE2218288A patent/DE2218288A1/de active Pending
-
1973
- 1973-04-11 BR BR732611A patent/BR7302611D0/pt unknown
- 1973-04-13 ZA ZA732578A patent/ZA732578B/xx unknown
- 1973-04-14 JP JP48041847A patent/JPS4914613A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109232288A (zh) * | 2018-09-27 | 2019-01-18 | 那坡康正天然植物提取有限责任公司 | 一种藜豆生产左旋多巴的方法 |
| CN109232288B (zh) * | 2018-09-27 | 2021-11-23 | 那坡康正天然植物提取有限责任公司 | 一种藜豆生产左旋多巴的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR7302611D0 (pt) | 1974-07-18 |
| JPS4914613A (enrdf_load_stackoverflow) | 1974-02-08 |
| ZA732578B (en) | 1974-03-27 |
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