DE2207309C3 - Isotopengenerator - Google Patents
IsotopengeneratorInfo
- Publication number
- DE2207309C3 DE2207309C3 DE2207309A DE2207309A DE2207309C3 DE 2207309 C3 DE2207309 C3 DE 2207309C3 DE 2207309 A DE2207309 A DE 2207309A DE 2207309 A DE2207309 A DE 2207309A DE 2207309 C3 DE2207309 C3 DE 2207309C3
- Authority
- DE
- Germany
- Prior art keywords
- generator
- carrier material
- isotope
- oxidizing agent
- saline solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012876 carrier material Substances 0.000 claims description 27
- 239000007800 oxidant agent Substances 0.000 claims description 27
- 230000002285 radioactive effect Effects 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 4
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 claims description 2
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 claims description 2
- XWNSFEAWWGGSKJ-UHFFFAOYSA-N 4-acetyl-4-methylheptanedinitrile Chemical compound N#CCCC(C)(C(=O)C)CCC#N XWNSFEAWWGGSKJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004153 Potassium bromate Substances 0.000 claims 1
- 229940094037 potassium bromate Drugs 0.000 claims 1
- 235000019396 potassium bromate Nutrition 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 35
- 238000010828 elution Methods 0.000 description 17
- 239000000243 solution Substances 0.000 description 10
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000003480 eluent Substances 0.000 description 5
- -1 alkali metal hypochlorite Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 229910001928 zirconium oxide Inorganic materials 0.000 description 3
- 229910052593 corundum Inorganic materials 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910001845 yogo sapphire Inorganic materials 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7102716.A NL165321C (nl) | 1971-03-02 | 1971-03-02 | Werkwijze voor de vervaardiging van een radio-isotopen producerende generator. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2207309A1 DE2207309A1 (de) | 1972-09-07 |
| DE2207309B2 DE2207309B2 (de) | 1980-11-20 |
| DE2207309C3 true DE2207309C3 (de) | 1981-07-30 |
Family
ID=19812592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2207309A Expired DE2207309C3 (de) | 1971-03-02 | 1972-02-17 | Isotopengenerator |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3785990A (enExample) |
| JP (1) | JPS544039B1 (enExample) |
| BE (1) | BE780010A (enExample) |
| CA (1) | CA971749A (enExample) |
| CH (1) | CH578235A5 (enExample) |
| DE (1) | DE2207309C3 (enExample) |
| FR (1) | FR2128373B1 (enExample) |
| GB (1) | GB1353293A (enExample) |
| IT (1) | IT947968B (enExample) |
| NL (1) | NL165321C (enExample) |
| SE (1) | SE387768B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3902849A (en) * | 1971-08-19 | 1975-09-02 | Medi Physics Inc | Radioisotope and radiopharmaceutical generators |
| NL165872C (nl) * | 1973-02-20 | 1981-05-15 | Byk Mallinckrodt Cil Bv | Isotopengenerator voor de produktie van 99m tc bevattende vloeistoffen. |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4041317A (en) * | 1976-05-19 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Multiple pH alumina columns for molybdenum-99/technetium-99m generators |
| US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| US4643891A (en) * | 1979-04-17 | 1987-02-17 | Mallinckrodt Diagnostica (Holland) B.V. | Preparation and use of a 195m Au-containing liquid |
| CA1169773A (en) * | 1979-04-17 | 1984-06-26 | Karel J. Panek | Preparation and use of a su195m xxau-containing liquid |
| RU2171512C2 (ru) * | 1999-06-21 | 2001-07-27 | Ермолаев Станислав Викторович | Способ производства генератора технеция-99м |
| US6998052B2 (en) * | 2002-04-12 | 2006-02-14 | Pg Research Foundation | Multicolumn selectivity inversion generator for production of ultrapure radionuclides |
| GB0506041D0 (en) * | 2005-03-24 | 2005-04-27 | Ge Healthcare Ltd | Stripping method |
| RU2443030C2 (ru) * | 2010-02-03 | 2012-02-20 | Федеральное государственное унитарное предприятие "Ордена Трудового Красного Знамени научно-исследовательский физико-химический институт им. Л.Я. Карпова" (ФГУП "НИФХИ им. Л.Я. Карпова") | ГЕНЕРАТОР ТЕХНЕЦИЯ-99m С СУЛЬФО-КАРБОКСИЛИРОВАННЫМ КАТИОНООБМЕННЫМ ЗАЩИТНЫМ СЛОЕМ И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3382152A (en) * | 1964-09-28 | 1968-05-07 | Union Carbide Corp | Production of high purity radioactive isotopes |
| NL6607699A (enExample) * | 1966-06-03 | 1967-12-04 | ||
| US3468808A (en) * | 1967-06-16 | 1969-09-23 | Union Carbide Corp | Production of high purity radioactive technetium-99m |
| US3664964A (en) * | 1968-07-03 | 1972-05-23 | Squibb & Sons Inc | Eluent for radioisotopes |
-
1971
- 1971-03-02 NL NL7102716.A patent/NL165321C/xx not_active IP Right Cessation
-
1972
- 1972-02-17 DE DE2207309A patent/DE2207309C3/de not_active Expired
- 1972-02-28 JP JP1975872A patent/JPS544039B1/ja active Pending
- 1972-02-28 FR FR7206671A patent/FR2128373B1/fr not_active Expired
- 1972-02-28 SE SE7202432A patent/SE387768B/xx unknown
- 1972-02-28 IT IT21138/72A patent/IT947968B/it active
- 1972-02-28 GB GB900772A patent/GB1353293A/en not_active Expired
- 1972-02-28 CA CA135,683A patent/CA971749A/en not_active Expired
- 1972-02-28 CH CH279272A patent/CH578235A5/xx not_active IP Right Cessation
- 1972-02-29 US US00230502A patent/US3785990A/en not_active Expired - Lifetime
- 1972-02-29 BE BE780010A patent/BE780010A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE780010A (fr) | 1972-08-29 |
| NL7102716A (enExample) | 1972-09-05 |
| SE387768B (sv) | 1976-09-13 |
| IT947968B (it) | 1973-05-30 |
| NL165321C (nl) | 1981-03-16 |
| FR2128373B1 (enExample) | 1983-04-08 |
| CH578235A5 (enExample) | 1976-07-30 |
| GB1353293A (en) | 1974-05-15 |
| US3785990A (en) | 1974-01-15 |
| DE2207309B2 (de) | 1980-11-20 |
| FR2128373A1 (enExample) | 1972-10-20 |
| DE2207309A1 (de) | 1972-09-07 |
| NL165321B (nl) | 1980-10-15 |
| JPS544039B1 (enExample) | 1979-03-01 |
| CA971749A (en) | 1975-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OGA | New person/name/address of the applicant | ||
| C3 | Grant after two publication steps (3rd publication) | ||
| 8310 | Action for declaration of annulment | ||
| 8313 | Request for invalidation rejected/withdrawn |