DE2207294C2 - Topische Salbengrundlage - Google Patents
Topische SalbengrundlageInfo
- Publication number
- DE2207294C2 DE2207294C2 DE2207294A DE2207294A DE2207294C2 DE 2207294 C2 DE2207294 C2 DE 2207294C2 DE 2207294 A DE2207294 A DE 2207294A DE 2207294 A DE2207294 A DE 2207294A DE 2207294 C2 DE2207294 C2 DE 2207294C2
- Authority
- DE
- Germany
- Prior art keywords
- steroid
- water
- skin
- ointment base
- propylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003883 ointment base Substances 0.000 title claims description 11
- 229940100615 topical ointment Drugs 0.000 title claims description 4
- 150000003431 steroids Chemical class 0.000 claims description 43
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 description 18
- 239000000203 mixture Substances 0.000 description 14
- 239000000499 gel Substances 0.000 description 13
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
- 239000002674 ointment Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- -1 Carboxyvinyl Chemical group 0.000 description 2
- 229920000298 Cellophane Polymers 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 230000037374 absorbed through the skin Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 2
- 229940043276 diisopropanolamine Drugs 0.000 description 2
- 229940124274 edetate disodium Drugs 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 240000001817 Cereus hexagonus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- WUGQZFFCHPXWKQ-UHFFFAOYSA-N Propanolamine Chemical compound NCCCO WUGQZFFCHPXWKQ-UHFFFAOYSA-N 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- SOQJPQZCPBDOMF-YCUXZELOSA-N betamethasone benzoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@@H]1C)C(=O)CO)C(=O)C1=CC=CC=C1 SOQJPQZCPBDOMF-YCUXZELOSA-N 0.000 description 1
- 229960000870 betamethasone benzoate Drugs 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- YZSJUQIFYHUSKU-UHFFFAOYSA-N ethanol;propane-1,2-diol Chemical compound CCO.CC(O)CO YZSJUQIFYHUSKU-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11897071A | 1971-02-25 | 1971-02-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2207294A1 DE2207294A1 (de) | 1972-09-07 |
| DE2207294C2 true DE2207294C2 (de) | 1982-12-02 |
Family
ID=22381865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2207294A Expired DE2207294C2 (de) | 1971-02-25 | 1972-02-16 | Topische Salbengrundlage |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3749773A (en, 2012) |
| JP (1) | JPS5218250B1 (en, 2012) |
| AU (1) | AU462514B2 (en, 2012) |
| CA (1) | CA946282A (en, 2012) |
| DE (1) | DE2207294C2 (en, 2012) |
| DK (2) | DK135267B (en, 2012) |
| FR (1) | FR2126383B1 (en, 2012) |
| GB (1) | GB1316556A (en, 2012) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7307072A (en, 2012) * | 1972-06-09 | 1973-12-11 | ||
| US3899580A (en) * | 1972-06-30 | 1975-08-12 | Merck & Co Inc | Anti-inflammatory topical gel |
| US3876771A (en) * | 1973-09-04 | 1975-04-08 | Hallister Inc | Skin protective gel containing polyvinyl methylether or monoisopropyl ester of polyvinyl methylether maleic acid |
| AU7776275A (en) * | 1974-04-11 | 1976-08-05 | Warner Lambert Co | Production of base for topical steroids |
| US4013792A (en) * | 1974-04-11 | 1977-03-22 | Warner-Lambert Company | Process for the production of base for topical steroids |
| JPS5842168B2 (ja) * | 1974-12-20 | 1983-09-17 | トウコウヤクヒンコウギヨウ カブシキガイシヤ | 局所用剤の製造方法 |
| US4102995A (en) * | 1976-05-13 | 1978-07-25 | Westwood Pharmaceuticals Inc. | Tar gel formulation |
| JPS52156913A (en) * | 1976-06-21 | 1977-12-27 | Toko Yakuhin Kogyo Kk | Production of injectionable medicine |
| JPS6056684B2 (ja) * | 1977-11-07 | 1985-12-11 | 東興薬品工業株式会社 | 点眼剤 |
| GB2013084B (en) * | 1978-01-25 | 1982-07-28 | Alcon Lab Inc | Ophthalmic drug dosage |
| GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
| DE2964471D1 (en) * | 1979-06-08 | 1983-02-17 | Toko Yakuhin Kogyo Kk | Creamy preparation containing steroid and process for the preparation thereof |
| CH655656B (en, 2012) * | 1982-10-07 | 1986-05-15 | ||
| US4489070A (en) * | 1983-05-13 | 1984-12-18 | Schering Corporation | Betamethasone dipropionate cream |
| WO1984004680A1 (en) * | 1983-05-25 | 1984-12-06 | Alcon Lab Inc | Ophthalmic gel |
| WO1984004681A1 (en) * | 1983-05-25 | 1984-12-06 | Alcon Lab Inc | Ophthalmic solution |
| JPS59222409A (ja) * | 1983-06-01 | 1984-12-14 | Nippon Redarii Kk | 消炎鎮痛ゲル軟膏剤 |
| EP0139127A1 (en) * | 1983-08-22 | 1985-05-02 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Transdermal drug delivery device and its preparation |
| US4543251A (en) * | 1983-12-09 | 1985-09-24 | Toko Yakuhin Industry Co., Ltd. | Gel preparations for external application |
| US4670254A (en) * | 1983-12-09 | 1987-06-02 | Toko Yakuhin Industry Co., Ltd. | Gel preparations for topical application of diclofenac sodium |
| US6255299B1 (en) | 1985-01-07 | 2001-07-03 | Leo Pharmaceutical Products Ltd. | Opthalmic gel composition and method of treating eye infections |
| GB8500310D0 (en) * | 1985-01-07 | 1985-02-13 | Leo Pharm Prod Ltd | Pharmaceutical preparation |
| US4775529A (en) * | 1987-05-21 | 1988-10-04 | Schering Corporation | Steroid lotion |
| US5110809A (en) * | 1988-03-21 | 1992-05-05 | Bristol-Myers Squibb Company | Antifungal gel formulations |
| US5002938A (en) * | 1988-03-21 | 1991-03-26 | Bristol-Myers Squibb Company | Antifungal gel formulations |
| US5075104A (en) * | 1989-03-31 | 1991-12-24 | Alcon Laboratories, Inc. | Ophthalmic carboxy vinyl polymer gel for dry eye syndrome |
| US4988500A (en) * | 1989-09-29 | 1991-01-29 | The Procter & Gamble Company | Oral compositions |
| AU2259692A (en) * | 1991-07-03 | 1993-02-11 | Sano Corporation | Composition and method for transdermal delivery of diclofenac |
| IT1265001B1 (it) * | 1993-12-16 | 1996-10-17 | Zambon Spa | Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico |
| DE60003074T2 (de) | 1999-10-15 | 2004-03-18 | Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab) | Fusidinsäure-derivate |
| US8921303B1 (en) * | 2014-01-28 | 2014-12-30 | Avon Products, Inc. | Extended release fragrance compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1047518A (en) * | 1963-06-11 | 1966-11-02 | Glaxo Lab Ltd | 17ª-monoesters of 11,17,21-trihydroxy steroid compounds |
| US3352753A (en) * | 1965-03-19 | 1967-11-14 | Squibb & Sons Inc | Pharmaceutical compositions of corticosteroids in gelled alcohol |
| IT1061787B (it) * | 1967-03-01 | 1983-04-30 | Vismara Francesco Spa | Miglioramenti relativi alla preparazione di 17 benzoato di betametazone |
-
0
- DK DK135267D patent/DK135267A/da unknown
-
1971
- 1971-02-25 US US00118970A patent/US3749773A/en not_active Expired - Lifetime
-
1972
- 1972-02-04 AU AU38683/72A patent/AU462514B2/en not_active Expired
- 1972-02-11 GB GB650572A patent/GB1316556A/en not_active Expired
- 1972-02-16 DE DE2207294A patent/DE2207294C2/de not_active Expired
- 1972-02-24 FR FR7206253A patent/FR2126383B1/fr not_active Expired
- 1972-02-24 CA CA135,504A patent/CA946282A/en not_active Expired
- 1972-02-24 DK DK87572AA patent/DK135267B/da not_active IP Right Cessation
- 1972-02-25 JP JP47019022A patent/JPS5218250B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3868372A (en) | 1973-08-09 |
| CA946282A (en) | 1974-04-30 |
| AU462514B2 (en) | 1975-06-11 |
| DK135267A (en, 2012) | |
| JPS5218250B1 (en, 2012) | 1977-05-20 |
| DK135267C (en, 2012) | 1977-09-19 |
| FR2126383B1 (en, 2012) | 1975-12-26 |
| GB1316556A (en) | 1973-05-09 |
| FR2126383A1 (en, 2012) | 1972-10-06 |
| DE2207294A1 (de) | 1972-09-07 |
| US3749773A (en) | 1973-07-31 |
| DK135267B (da) | 1977-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| D2 | Grant after examination | ||
| 8363 | Opposition against the patent | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: ZUMSTEIN SEN., F., DR. ASSMANN, E., DIPL.-CHEM. DR.RER.NAT. ZUMSTEIN JUN., F., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN |
|
| 8365 | Fully valid after opposition proceedings |