DE2150361A1 - Prostanoesaeurederivate - Google Patents

Prostanoesaeurederivate

Info

Publication number
DE2150361A1
DE2150361A1 DE19712150361 DE2150361A DE2150361A1 DE 2150361 A1 DE2150361 A1 DE 2150361A1 DE 19712150361 DE19712150361 DE 19712150361 DE 2150361 A DE2150361 A DE 2150361A DE 2150361 A1 DE2150361 A1 DE 2150361A1
Authority
DE
Germany
Prior art keywords
radical
carbon atoms
hydroxy
acid
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19712150361
Other languages
German (de)
English (en)
Inventor
Mallion Keith Blackeney
Jean Bowler
Richard Clarkson
Crossley Neville Stanton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of DE2150361A1 publication Critical patent/DE2150361A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19712150361 1970-10-09 1971-10-08 Prostanoesaeurederivate Pending DE2150361A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB48131/70*2A GB1356581A (en) 1970-10-09 1970-10-09 Cyclopentane derivatives
GB181471 1971-01-14
GB554371 1971-02-26

Publications (1)

Publication Number Publication Date
DE2150361A1 true DE2150361A1 (de) 1972-04-13

Family

ID=27253947

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712150361 Pending DE2150361A1 (de) 1970-10-09 1971-10-08 Prostanoesaeurederivate

Country Status (9)

Country Link
BE (1) BE773728A (enExample)
DE (1) DE2150361A1 (enExample)
ES (1) ES395814A1 (enExample)
FR (1) FR2110335B1 (enExample)
GB (1) GB1356581A (enExample)
HU (1) HU163414B (enExample)
IL (1) IL37821A0 (enExample)
NL (1) NL7113880A (enExample)
ZM (1) ZM14271A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933889A (en) * 1972-04-27 1976-01-20 The Upjohn Company 4,5-Cis-didehydro-PGF1.sub.α analogs
US3954741A (en) * 1972-06-07 1976-05-04 Pfizer Inc. N-substituted prostaglandin carboxamides
DE2319017B2 (de) * 1972-04-17 1978-06-08 Pfizer Inc., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von Prostaglandinen der Eins-Reihe

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1520522A (en) * 1975-06-16 1978-08-09 Ono Pharmaceutical Co 16-methyleneprostaglandins
US5236907A (en) * 1988-10-01 1993-08-17 R-Tech Ueno Ltd. Ocular hypotensive agents
US6420422B1 (en) 1987-09-18 2002-07-16 Sucampo Pharmaceuticals, Inc. Ocular hypotensive agents
ATE111736T1 (de) * 1988-10-01 1994-10-15 R Tech Ueno Ltd Okulare hypotensive mittel.
US5194429A (en) * 1988-10-01 1993-03-16 K.K. Ueno Seiyaku Oyo Kenkyujo Ocular hypotensive agents
ES2466346T3 (es) 2006-10-02 2014-06-10 Techfields Biochem Co. Ltd Profármacos de prostaglandinas solubles en agua con carga positiva y compuestos relacionados con índices de penetración en la piel muy altos
JP6030168B2 (ja) * 2015-03-09 2016-11-24 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP6306067B2 (ja) * 2016-01-08 2018-04-04 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP7141025B1 (ja) * 2021-11-11 2022-09-22 エルデシエロ プライベート リミテッド 化合物、組成物、方法、及び製造方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319017B2 (de) * 1972-04-17 1978-06-08 Pfizer Inc., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von Prostaglandinen der Eins-Reihe
DE2319017C3 (de) * 1972-04-17 1979-02-01 Pfizer Inc., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von Prostaglandinen der Eins-Reihe
US3933889A (en) * 1972-04-27 1976-01-20 The Upjohn Company 4,5-Cis-didehydro-PGF1.sub.α analogs
US3954741A (en) * 1972-06-07 1976-05-04 Pfizer Inc. N-substituted prostaglandin carboxamides

Also Published As

Publication number Publication date
FR2110335B1 (enExample) 1975-06-06
GB1356581A (en) 1974-06-12
ZM14271A1 (en) 1972-06-21
SU439962A3 (ru) 1974-08-15
BE773728A (fr) 1972-04-10
FR2110335A1 (enExample) 1972-06-02
HU163414B (enExample) 1973-08-28
ES395814A1 (es) 1975-03-01
NL7113880A (enExample) 1972-04-11
IL37821A0 (en) 1971-11-29

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