DE2143744A1 - 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung - Google Patents

3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung

Info

Publication number
DE2143744A1
DE2143744A1 DE2143744A DE2143744A DE2143744A1 DE 2143744 A1 DE2143744 A1 DE 2143744A1 DE 2143744 A DE2143744 A DE 2143744A DE 2143744 A DE2143744 A DE 2143744A DE 2143744 A1 DE2143744 A1 DE 2143744A1
Authority
DE
Germany
Prior art keywords
dihydro
phenyl
isoquinolin
carbon atoms
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2143744A
Other languages
German (de)
English (en)
Inventor
Ernold Dipl Chem Dr Dr Granzer
Rudolf Dipl Chem Dr Kunstmann
Guenther Dipl Chem Dr Seidl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE2143744A priority Critical patent/DE2143744A1/de
Priority to CA148,981A priority patent/CA983039A/en
Priority to DD165086A priority patent/DD102147A5/xx
Priority to NL7211626A priority patent/NL7211626A/xx
Priority to BG023337A priority patent/BG19799A3/xx
Priority to BG023338A priority patent/BG19375A3/xx
Priority to BG021265A priority patent/BG20410A3/xx
Priority to IL40249A priority patent/IL40249A0/xx
Priority to AU46103/72A priority patent/AU4610372A/en
Priority to ZA725996A priority patent/ZA725996B/xx
Priority to FR7230950A priority patent/FR2151043A1/fr
Priority to JP47087840A priority patent/JPS4834886A/ja
Priority to HUHO1512A priority patent/HU165204B/hu
Priority to BE788322D priority patent/BE788322A/xx
Publication of DE2143744A1 publication Critical patent/DE2143744A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/215—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE2143744A 1971-09-01 1971-09-01 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung Pending DE2143744A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE2143744A DE2143744A1 (de) 1971-09-01 1971-09-01 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung
CA148,981A CA983039A (en) 1971-09-01 1972-08-09 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them
DD165086A DD102147A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-09-01 1972-08-16
NL7211626A NL7211626A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-09-01 1972-08-25
BG023337A BG19799A3 (bg) 1971-09-01 1972-08-28 Метод за получаване на 3,4-дихидро-2н-изохинолин-1-они
BG023338A BG19375A3 (bg) 1971-09-01 1972-08-28 Метод за получаване на 3,4-1н-изохиномин-1-они
BG021265A BG20410A3 (bg) 1971-09-01 1972-08-28 Метод за получаване на 3,4-дихидро-2н- изохинолин-1-они
IL40249A IL40249A0 (en) 1971-09-01 1972-08-29 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them
AU46103/72A AU4610372A (en) 1971-09-01 1972-08-30 3, 4-dihydro-2h-isoquinoline-1-ones and process for preparing them
ZA725996A ZA725996B (en) 1971-09-01 1972-08-31 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them
FR7230950A FR2151043A1 (en) 1971-09-01 1972-08-31 3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum
JP47087840A JPS4834886A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-09-01 1972-09-01
HUHO1512A HU165204B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-09-01 1972-09-01
BE788322D BE788322A (fr) 1971-09-01 1972-09-01 3,4-dihydro-2h-isoquinoleine-1-ones et medicaments qui en contiennent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2143744A DE2143744A1 (de) 1971-09-01 1971-09-01 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE2143744A1 true DE2143744A1 (de) 1973-03-08

Family

ID=5818353

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2143744A Pending DE2143744A1 (de) 1971-09-01 1971-09-01 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung

Country Status (12)

Country Link
JP (1) JPS4834886A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU4610372A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE788322A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (3) BG19375A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA983039A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD102147A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2143744A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2151043A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU165204B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL40249A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7211626A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA725996B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2281763A1 (fr) * 1974-08-14 1976-03-12 Hoechst Ag 3,4-dihydro-2h-isoquinoleine-1-ones a substituant basique, leur procede de preparation et leurs applications
EP0167820A3 (en) * 1984-06-14 1986-09-17 Bayer Ag Process for the preparation of optionally substituted benz(c,d)-indol-2-ones (naphtholactames)
WO2008070496A3 (en) * 2006-12-01 2008-09-18 Bristol Myers Squibb Co N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN104822687A (zh) * 2012-10-02 2015-08-05 英特穆恩公司 抗纤维化吡啶酮类
USRE47142E1 (en) 2008-06-03 2018-11-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5650682B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1974-03-25 1981-12-01
GB1576511A (en) * 1977-03-29 1980-10-08 Parcor Thieno(2,3 - c) and (3,2 - c) pyridines process for their preparation and therapeutic applications thereof

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2281763A1 (fr) * 1974-08-14 1976-03-12 Hoechst Ag 3,4-dihydro-2h-isoquinoleine-1-ones a substituant basique, leur procede de preparation et leurs applications
EP0167820A3 (en) * 1984-06-14 1986-09-17 Bayer Ag Process for the preparation of optionally substituted benz(c,d)-indol-2-ones (naphtholactames)
WO2008070496A3 (en) * 2006-12-01 2008-09-18 Bristol Myers Squibb Co N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US9102599B2 (en) 2006-12-01 2015-08-11 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
USRE47142E1 (en) 2008-06-03 2018-11-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
EP2903991A4 (en) * 2012-10-02 2016-09-07 Intermune Inc ANTIFIBROTIC PYRIDINONE
US9675593B2 (en) 2012-10-02 2017-06-13 Intermune, Inc. Anti-fibrotic pyridinones
CN104822687A (zh) * 2012-10-02 2015-08-05 英特穆恩公司 抗纤维化吡啶酮类
US10376497B2 (en) 2012-10-02 2019-08-13 Intermune, Inc. Anti-fibrotic pyridinones
US10898474B2 (en) 2012-10-02 2021-01-26 Intermune, Inc. Anti-fibrotic pyridinones
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
US10544161B2 (en) 2014-04-02 2020-01-28 Intermune, Inc. Anti-fibrotic pyridinones

Also Published As

Publication number Publication date
ZA725996B (en) 1973-06-27
NL7211626A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-03-05
FR2151043A1 (en) 1973-04-13
BG20410A3 (bg) 1975-11-05
BG19799A3 (bg) 1975-10-10
JPS4834886A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-05-22
IL40249A0 (en) 1972-10-29
AU4610372A (en) 1974-03-07
CA983039A (en) 1976-02-03
BE788322A (fr) 1973-03-01
HU165204B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-07-27
DD102147A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-12-05
BG19375A3 (bg) 1975-06-15

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