DE2117442B2 - Verfahren zur Herstellung eines a -e-Desoxytetracyclins - Google Patents

Verfahren zur Herstellung eines a -e-Desoxytetracyclins

Info

Publication number
DE2117442B2
DE2117442B2 DE2117442A DE2117442A DE2117442B2 DE 2117442 B2 DE2117442 B2 DE 2117442B2 DE 2117442 A DE2117442 A DE 2117442A DE 2117442 A DE2117442 A DE 2117442A DE 2117442 B2 DE2117442 B2 DE 2117442B2
Authority
DE
Germany
Prior art keywords
base
doxycycline
sulfosalicylate
deoxy
titer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE2117442A
Other languages
German (de)
English (en)
Other versions
DE2117442A1 (de
Inventor
Franco Paolo Naviglio Mailand Luciano (Italien)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rachelle Laboratories Italia SpA
Original Assignee
Rachelle Laboratories Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rachelle Laboratories Italia SpA filed Critical Rachelle Laboratories Italia SpA
Publication of DE2117442A1 publication Critical patent/DE2117442A1/de
Publication of DE2117442B2 publication Critical patent/DE2117442B2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2117442A 1970-12-28 1971-04-08 Verfahren zur Herstellung eines a -e-Desoxytetracyclins Withdrawn DE2117442B2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10209470A 1970-12-28 1970-12-28

Publications (2)

Publication Number Publication Date
DE2117442A1 DE2117442A1 (de) 1972-07-27
DE2117442B2 true DE2117442B2 (de) 1980-06-04

Family

ID=22288092

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2117442A Withdrawn DE2117442B2 (de) 1970-12-28 1971-04-08 Verfahren zur Herstellung eines a -e-Desoxytetracyclins

Country Status (17)

Country Link
US (1) US3795707A (xx)
JP (1) JPS535299B1 (xx)
BE (1) BE777357A (xx)
CA (1) CA972745A (xx)
CH (1) CH567456A5 (xx)
DE (1) DE2117442B2 (xx)
DK (1) DK139576B (xx)
ES (1) ES391290A1 (xx)
FI (1) FI53302B (xx)
FR (1) FR2120866A5 (xx)
GB (1) GB1370797A (xx)
IE (1) IE35673B1 (xx)
IL (1) IL37883A (xx)
NL (1) NL7113277A (xx)
NO (1) NO133102C (xx)
SE (1) SE373836B (xx)
ZA (1) ZA716574B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906043A (en) * 1969-06-12 1975-09-16 Israel Marcus Water-soluble tetracyclines
US4061676A (en) * 1970-07-03 1977-12-06 Ivan Villax Recovery of doxycycline and products thereof
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EP2311799A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
IL164180A0 (en) 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EA201100956A1 (ru) 2003-07-09 2012-01-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH365484A (fr) * 1956-05-28 1962-11-15 American Cyanamid Co Procédé de préparation d'une substance antibiotique
FR1430859A (xx) * 1960-05-23 1966-05-25
US3397231A (en) * 1967-04-12 1968-08-13 Pfizer & Co C Refining of alpha-6-deoxy-5-oxytetracycline
CA945546A (en) * 1970-07-03 1974-04-16 Ivan Villax Recovery of doxycycline and products thereof

Also Published As

Publication number Publication date
IE35673L (en) 1972-06-28
CA972745A (en) 1975-08-12
GB1370797A (en) 1974-10-16
CH567456A5 (xx) 1975-10-15
JPS535299B1 (xx) 1978-02-25
BE777357A (fr) 1972-04-17
NO133102C (xx) 1976-03-10
IE35673B1 (en) 1976-04-14
IL37883A (en) 1974-12-31
DK139576B (da) 1979-03-12
ZA716574B (en) 1973-05-30
IL37883A0 (en) 1971-12-29
FI53302B (xx) 1977-12-30
SE373836B (xx) 1975-02-17
ES391290A1 (es) 1972-01-16
DE2117442A1 (de) 1972-07-27
DK139576C (xx) 1979-08-27
NO133102B (xx) 1975-12-01
FR2120866A5 (xx) 1972-08-18
US3795707A (en) 1974-03-05
NL7113277A (xx) 1972-06-30

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Legal Events

Date Code Title Description
OD Request for examination
8239 Disposal/non-payment of the annual fee