ES391290A1 - Procedimiento para la obtencion de alfa-6-deoxitetracicli- nas. - Google Patents

Procedimiento para la obtencion de alfa-6-deoxitetracicli- nas.

Info

Publication number
ES391290A1
ES391290A1 ES391290A ES391290A ES391290A1 ES 391290 A1 ES391290 A1 ES 391290A1 ES 391290 A ES391290 A ES 391290A ES 391290 A ES391290 A ES 391290A ES 391290 A1 ES391290 A1 ES 391290A1
Authority
ES
Spain
Prior art keywords
deoxytetracyclines
alpha
manufacture
deoxytetracycline
methylenetetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES391290A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rachelle Laboratories Italia SpA
Original Assignee
Rachelle Laboratories Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rachelle Laboratories Italia SpA filed Critical Rachelle Laboratories Italia SpA
Publication of ES391290A1 publication Critical patent/ES391290A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60Reduction reactions, e.g. hydrogenation
    • B01J2231/64Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/461,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES391290A 1970-12-28 1971-05-18 Procedimiento para la obtencion de alfa-6-deoxitetracicli- nas. Expired ES391290A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10209470A 1970-12-28 1970-12-28

Publications (1)

Publication Number Publication Date
ES391290A1 true ES391290A1 (es) 1972-01-16

Family

ID=22288092

Family Applications (1)

Application Number Title Priority Date Filing Date
ES391290A Expired ES391290A1 (es) 1970-12-28 1971-05-18 Procedimiento para la obtencion de alfa-6-deoxitetracicli- nas.

Country Status (17)

Country Link
US (1) US3795707A (es)
JP (1) JPS535299B1 (es)
BE (1) BE777357A (es)
CA (1) CA972745A (es)
CH (1) CH567456A5 (es)
DE (1) DE2117442B2 (es)
DK (1) DK139576B (es)
ES (1) ES391290A1 (es)
FI (1) FI53302B (es)
FR (1) FR2120866A5 (es)
GB (1) GB1370797A (es)
IE (1) IE35673B1 (es)
IL (1) IL37883A (es)
NL (1) NL7113277A (es)
NO (1) NO133102C (es)
SE (1) SE373836B (es)
ZA (1) ZA716574B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906043A (en) * 1969-06-12 1975-09-16 Israel Marcus Water-soluble tetracyclines
US4061676A (en) * 1970-07-03 1977-12-06 Ivan Villax Recovery of doxycycline and products thereof
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EP2311799A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
IL164180A0 (en) 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EA201100956A1 (ru) 2003-07-09 2012-01-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH365484A (fr) * 1956-05-28 1962-11-15 American Cyanamid Co Procédé de préparation d'une substance antibiotique
FR1430859A (es) * 1960-05-23 1966-05-25
US3397231A (en) * 1967-04-12 1968-08-13 Pfizer & Co C Refining of alpha-6-deoxy-5-oxytetracycline
CA945546A (en) * 1970-07-03 1974-04-16 Ivan Villax Recovery of doxycycline and products thereof

Also Published As

Publication number Publication date
IE35673L (en) 1972-06-28
CA972745A (en) 1975-08-12
GB1370797A (en) 1974-10-16
DE2117442B2 (de) 1980-06-04
CH567456A5 (es) 1975-10-15
JPS535299B1 (es) 1978-02-25
BE777357A (fr) 1972-04-17
NO133102C (es) 1976-03-10
IE35673B1 (en) 1976-04-14
IL37883A (en) 1974-12-31
DK139576B (da) 1979-03-12
ZA716574B (en) 1973-05-30
IL37883A0 (en) 1971-12-29
FI53302B (es) 1977-12-30
SE373836B (es) 1975-02-17
DE2117442A1 (de) 1972-07-27
DK139576C (es) 1979-08-27
NO133102B (es) 1975-12-01
FR2120866A5 (es) 1972-08-18
US3795707A (en) 1974-03-05
NL7113277A (es) 1972-06-30

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