DE206454C - - Google Patents
Info
- Publication number
- DE206454C DE206454C DENDAT206454D DE206454DA DE206454C DE 206454 C DE206454 C DE 206454C DE NDAT206454 D DENDAT206454 D DE NDAT206454D DE 206454D A DE206454D A DE 206454DA DE 206454 C DE206454 C DE 206454C
- Authority
- DE
- Germany
- Prior art keywords
- diaminopyrimidine
- derivatives
- acid
- parts
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- 229940058936 antimalarials diaminopyrimidines Drugs 0.000 claims description 4
- 150000001735 carboxylic acids Chemical class 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 2
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims 2
- 229910052709 silver Inorganic materials 0.000 claims 2
- 239000004332 silver Substances 0.000 claims 2
- WAKFRZBXTKUFIW-UHFFFAOYSA-N 2-bromo-2-phenylacetic acid Chemical compound OC(=O)C(Br)C1=CC=CC=C1 WAKFRZBXTKUFIW-UHFFFAOYSA-N 0.000 claims 1
- KMRNTNDWADEIIX-UHFFFAOYSA-N 3-Iodopropanoic acid Chemical compound OC(=O)CCI KMRNTNDWADEIIX-UHFFFAOYSA-N 0.000 claims 1
- OSLCJYYQMKPZHU-UHFFFAOYSA-N 3-chlorolactic acid Chemical compound ClCC(O)C(O)=O OSLCJYYQMKPZHU-UHFFFAOYSA-N 0.000 claims 1
- 102100022404 E3 ubiquitin-protein ligase Midline-1 Human genes 0.000 claims 1
- 101710102210 E3 ubiquitin-protein ligase Midline-1 Proteins 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 229960005215 dichloroacetic acid Drugs 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 241000790917 Dioxys <bee> Species 0.000 description 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 101150032584 oxy-4 gene Proteins 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229940106681 chloroacetic acid Drugs 0.000 description 1
- 125000002668 chloroacetyl group Chemical group ClCC(=O)* 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 description 1
- MISVBCMQSJUHMH-UHFFFAOYSA-N pyrimidine-4,6-diamine Chemical class NC1=CC(N)=NC=N1 MISVBCMQSJUHMH-UHFFFAOYSA-N 0.000 description 1
- 150000003252 quinoxalines Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE206454C true DE206454C (enrdf_load_stackoverflow) |
Family
ID=468621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT206454D Active DE206454C (enrdf_load_stackoverflow) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE206454C (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2437853A (en) * | 1943-12-01 | 1948-03-16 | Burroughs Wellcome Co | Preparation of dihydroxanthopterin and xanthopterin |
| US2494125A (en) * | 1950-01-10 | S-acylamino ukacils and process of | ||
| US2515483A (en) * | 1946-08-10 | 1950-07-18 | Merck & Co Inc | Diacylated pteroic acid and process for preparing same |
-
0
- DE DENDAT206454D patent/DE206454C/de active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2494125A (en) * | 1950-01-10 | S-acylamino ukacils and process of | ||
| US2437853A (en) * | 1943-12-01 | 1948-03-16 | Burroughs Wellcome Co | Preparation of dihydroxanthopterin and xanthopterin |
| US2515483A (en) * | 1946-08-10 | 1950-07-18 | Merck & Co Inc | Diacylated pteroic acid and process for preparing same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE1132784B (de) | Konservieren von Pflanzenmaterial mittels Adeninderivaten | |
| DE1793517A1 (de) | N.N.'-Di-tert.Butyloxycarbonyl-insulin und Verfahren zu seiner Herstellung | |
| DE206454C (enrdf_load_stackoverflow) | ||
| DE1236510B (de) | Verfahren zur Herstellung von Acylaminotetramsaeuren | |
| DE3308719A1 (de) | 1-substituierte n-(8(alpha)-ergolinyl)-n'.n'-diethylharnstoffe, ihre herstellung und pharmakologische verwendung | |
| DE624230C (de) | Verfahren zur Herstellung von Glutamin | |
| DE1695415A1 (de) | omega-n-Alkyl-glutamat- bzw.-asparaginat-N-carboxyanhydride und Verfahren zu deren Herstellung | |
| DE3426195A1 (de) | Verfahren zur herstellung von in 2-stellung substituierten imidazol-4,5-dicarbonsaeuren | |
| DE209728C (enrdf_load_stackoverflow) | ||
| DE901650C (de) | Verfahren zur Herstellung von therapeutisch wertvollen Verbindungen des p-Aminobenzolsulfonhydrazids | |
| DE1518349C3 (de) | Verfahren zur Herstellung eledoisinwirksamer Verbindungen | |
| DE904534C (de) | Verfahren zur Herstellung von Nicotinsaeureesternitraten | |
| DE1963925C3 (de) | Verfahren zur Herstellung von N hoch 3-Carbalkoxyderivaten des 5,5-Diphenylhydantoins | |
| DE921149C (de) | Verfahren zur Herstellung von d, l-Dihydro-nor-lysergylglycinamid | |
| DE156055C (enrdf_load_stackoverflow) | ||
| DE166448C (enrdf_load_stackoverflow) | ||
| DE222809C (enrdf_load_stackoverflow) | ||
| DE964496C (de) | Verfahren zur Wiedergewinnung des bei der Herstellung von Cyclotrimethylentrinitramin anfallenden Formaldehyd- und Salpetersaeureueberschusses | |
| DE965325C (de) | Verfahren zur Herstellung des Streptomycinisonicotinsaeurehydrazons und seinen Salzen | |
| DE213155C (enrdf_load_stackoverflow) | ||
| DE213711C (enrdf_load_stackoverflow) | ||
| DE203717C (enrdf_load_stackoverflow) | ||
| DE941062C (de) | Verfahren zur Herstellung von Furan-(2)-carbonsaeurederivaten | |
| DE1045413B (de) | Verfahren zur Herstellung von L-Glutamin | |
| DE296495C (enrdf_load_stackoverflow) |