DE2051871A1 - Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents - Google Patents

Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents

Info

Publication number
DE2051871A1
DE2051871A1 DE19702051871 DE2051871A DE2051871A1 DE 2051871 A1 DE2051871 A1 DE 2051871A1 DE 19702051871 DE19702051871 DE 19702051871 DE 2051871 A DE2051871 A DE 2051871A DE 2051871 A1 DE2051871 A1 DE 2051871A1
Authority
DE
Germany
Prior art keywords
compound
formula
group
reaction
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19702051871
Other languages
German (de)
English (en)
Other versions
DE2051871C2 (enrdf_load_stackoverflow
Inventor
Ronald Morton Scarsdale; Mentha John William Hartsdale N.Y. Cresswell (V.St.A.)
Joseph Donald West CaIdwell N.J. Surmatis (V.St.A.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25759946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2051871(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to DE19702051871 priority Critical patent/DE2051871A1/de
Publication of DE2051871A1 publication Critical patent/DE2051871A1/de
Application granted granted Critical
Publication of DE2051871C2 publication Critical patent/DE2051871C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19702051871 1969-05-16 1970-05-15 Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents Granted DE2051871A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19702051871 DE2051871A1 (en) 1969-05-16 1970-05-15 Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2517169 1969-05-16
DE19702051871 DE2051871A1 (en) 1969-05-16 1970-05-15 Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents

Publications (2)

Publication Number Publication Date
DE2051871A1 true DE2051871A1 (en) 1971-11-18
DE2051871C2 DE2051871C2 (enrdf_load_stackoverflow) 1987-05-27

Family

ID=25759946

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19702051871 Granted DE2051871A1 (en) 1969-05-16 1970-05-15 Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents

Country Status (1)

Country Link
DE (1) DE2051871A1 (enrdf_load_stackoverflow)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013126360A3 (en) * 2012-02-21 2013-10-31 Celgene Corporation Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine
US9018243B2 (en) 2002-03-20 2015-04-28 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US9468605B2 (en) 2013-06-17 2016-10-18 Celgene Corporation Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US10300042B2 (en) 2014-06-23 2019-05-28 Celgene Corporation Apremilast for the treatment of a liver disease or a liver function abnormality

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1103931B (de) * 1957-02-21 1961-04-06 Wellcome Found Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
US3049544A (en) * 1962-08-14 Method for the preparation of
NL6609626A (enrdf_load_stackoverflow) * 1965-07-08 1967-01-09
DE1445176A1 (de) * 1959-09-03 1968-10-17 Wellcome Found Neuartige organische chemische Verbindungen sowie Verfahren zu deren Herstellung
DE2066039B2 (de) * 1969-03-06 1979-01-11 The Wellcome Foundation Ltd., London Verfahren zur Herstellung von 23-Diamitio-5-benzylpyrimidinen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1103931B (de) * 1957-02-21 1961-04-06 Wellcome Found Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
DE1445176A1 (de) * 1959-09-03 1968-10-17 Wellcome Found Neuartige organische chemische Verbindungen sowie Verfahren zu deren Herstellung
NL6609626A (enrdf_load_stackoverflow) * 1965-07-08 1967-01-09
DE2066039B2 (de) * 1969-03-06 1979-01-11 The Wellcome Foundation Ltd., London Verfahren zur Herstellung von 23-Diamitio-5-benzylpyrimidinen

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9433606B2 (en) 2002-03-20 2016-09-06 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US9018243B2 (en) 2002-03-20 2015-04-28 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US9586897B2 (en) 2012-02-21 2017-03-07 Celgene Corporation Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
AU2013203283B2 (en) * 2012-02-21 2015-11-26 Amgen (Europe) GmbH Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
US9187417B2 (en) 2012-02-21 2015-11-17 Celgene Corporation Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
WO2013126360A3 (en) * 2012-02-21 2013-10-31 Celgene Corporation Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine
US9688623B2 (en) 2012-02-21 2017-06-27 Celgene Corporation Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
RU2632875C2 (ru) * 2012-02-21 2017-10-11 Селджин Корпорейшн Способы получения (s)-1-(3-этокси-4-метоксифенил)-2- метансульфонилэтиламина
EP3312156A1 (en) * 2012-02-21 2018-04-25 Celgene Corporation Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine
CN112812044A (zh) * 2012-02-21 2021-05-18 安进(欧洲)有限责任公司 用于制备(s)-1-(3-乙氧基-4-甲氧基苯基)-2-甲烷磺酰基乙胺的工艺
CN112812044B (zh) * 2012-02-21 2023-05-30 安进(欧洲)有限责任公司 用于制备(s)-1-(3-乙氧基-4-甲氧基苯基)-2-甲烷磺酰基乙胺的工艺
US9468605B2 (en) 2013-06-17 2016-10-18 Celgene Corporation Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US10300042B2 (en) 2014-06-23 2019-05-28 Celgene Corporation Apremilast for the treatment of a liver disease or a liver function abnormality

Also Published As

Publication number Publication date
DE2051871C2 (enrdf_load_stackoverflow) 1987-05-27

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