DE2050714C2 - Polysaccharid mit Antitumoraktivität, Verfahren zu seiner Gewinnung und seine Verwendung als Wirkstoff in Antitumormitteln - Google Patents
Polysaccharid mit Antitumoraktivität, Verfahren zu seiner Gewinnung und seine Verwendung als Wirkstoff in AntitumormittelnInfo
- Publication number
- DE2050714C2 DE2050714C2 DE2050714A DE2050714A DE2050714C2 DE 2050714 C2 DE2050714 C2 DE 2050714C2 DE 2050714 A DE2050714 A DE 2050714A DE 2050714 A DE2050714 A DE 2050714A DE 2050714 C2 DE2050714 C2 DE 2050714C2
- Authority
- DE
- Germany
- Prior art keywords
- polyporaceae
- polysaccharide
- water
- reaction
- mycelium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000006035 Tryptophane Substances 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- CAMXVZOXBADHNJ-UHFFFAOYSA-N ammonium nitrite Chemical compound [NH4+].[O-]N=O CAMXVZOXBADHNJ-UHFFFAOYSA-N 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- MMCPOSDMTGQNKG-UHFFFAOYSA-N anilinium chloride Chemical compound Cl.NC1=CC=CC=C1 MMCPOSDMTGQNKG-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- AYJRCSIUFZENHW-DEQYMQKBSA-L barium(2+);oxomethanediolate Chemical compound [Ba+2].[O-][14C]([O-])=O AYJRCSIUFZENHW-DEQYMQKBSA-L 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- HLVXFWDLRHCZEI-UHFFFAOYSA-N chromotropic acid Chemical compound OS(=O)(=O)C1=CC(O)=C2C(O)=CC(S(O)(=O)=O)=CC2=C1 HLVXFWDLRHCZEI-UHFFFAOYSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000110 cooling liquid Substances 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229940056932 lead sulfide Drugs 0.000 description 1
- 229910052981 lead sulfide Inorganic materials 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- -1 potassium phosphate Magnesium sulfate heptahydrate Calcium phosphate Chemical compound 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8181369A JPS55363B1 (enrdf_load_html_response) | 1969-10-15 | 1969-10-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2050714A1 DE2050714A1 (de) | 1971-04-22 |
| DE2050714C2 true DE2050714C2 (de) | 1985-09-19 |
Family
ID=13756923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2050714A Expired DE2050714C2 (de) | 1969-10-15 | 1970-10-15 | Polysaccharid mit Antitumoraktivität, Verfahren zu seiner Gewinnung und seine Verwendung als Wirkstoff in Antitumormitteln |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS55363B1 (enrdf_load_html_response) |
| BE (1) | BE757248A (enrdf_load_html_response) |
| CA (1) | CA983870A (enrdf_load_html_response) |
| CH (1) | CH587345A5 (enrdf_load_html_response) |
| DE (1) | DE2050714C2 (enrdf_load_html_response) |
| FR (1) | FR2070133B1 (enrdf_load_html_response) |
| GB (1) | GB1331513A (enrdf_load_html_response) |
| NL (1) | NL7014572A (enrdf_load_html_response) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1356449A (en) * | 1970-12-30 | 1974-06-12 | Iizuka C | Process for extracting water soluble components of the hyphae of edible fungi |
| JPS5290614A (en) * | 1975-12-18 | 1977-07-30 | Kureha Chem Ind Co Ltd | Preparation of anti-tumor substance |
| PH14773A (en) | 1976-01-01 | 1981-12-09 | Kureha Chemical Ind Co Ltd | Protein-bound polysaccharides |
| JPS536413A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS536412A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS5315495A (en) * | 1976-07-22 | 1978-02-13 | Kureha Chem Ind Co Ltd | Preparation of polysaccharides |
| JPS5366412A (en) * | 1976-10-30 | 1978-06-13 | Sato Akihiko | Extracting and separating effective component of mushroom *1mannentake1* |
| JPS5394012A (en) * | 1977-01-27 | 1978-08-17 | Kureha Chem Ind Co Ltd | Novel polysaccharide and its preparation |
| GB1572074A (en) * | 1977-03-30 | 1980-07-23 | Kirin Seagram Ltd | Chemotherapeutic substances and methods of manufacturing same |
| JPS5446830A (en) * | 1977-09-16 | 1979-04-13 | Kureha Chem Ind Co Ltd | Pesticide for plant viral disease |
| JPS5542564A (en) * | 1978-09-21 | 1980-03-25 | Takara Shuzo Co Ltd | Production of antitumorigenic substance |
| JPS5635989A (en) * | 1979-08-16 | 1981-04-08 | Sumitomo Chem Co Ltd | Preparation of carcinostatic substance |
| JPS5712999A (en) * | 1980-06-25 | 1982-01-22 | Chiyokichi Iizuka | Antibiral agent and its preparation |
| JPS5932480B2 (ja) * | 1981-02-10 | 1984-08-09 | 呉羽化学工業株式会社 | 新規な糖蛋白複合体 |
| US7514085B2 (en) | 2004-07-16 | 2009-04-07 | Medimush A/S | Immune modulating compounds from fungi |
| EP1709969A1 (en) * | 2005-04-07 | 2006-10-11 | Praktijkonderzoek Plant en Omgeving B.V. | Health promoting dairy and food products containing mushroom glucan produced through fermentation of Grifola frondosa |
| US9072776B2 (en) * | 2005-06-15 | 2015-07-07 | Glycanova As | Anti-cancer combination treatment and kit-of-parts |
| CN109609525A (zh) * | 2019-01-10 | 2019-04-12 | 江苏大学 | 灰树花葡聚糖合成酶、其编码基因及应用 |
| CN116769059B (zh) * | 2022-03-09 | 2025-01-28 | 东北师范大学 | 一种具有免疫佐剂活性真菌半乳聚糖及其制备方法与应用 |
| CN114875174B (zh) * | 2022-06-28 | 2023-07-07 | 上海市农业科学院 | 一种快速鉴别毒红菇的lamp引物组、试剂盒及检测方法 |
| CN116062907B (zh) * | 2023-02-09 | 2024-10-01 | 中国科学院南京土壤研究所 | 一种水体中PAHs的微生物降解净化方法 |
| CN116751315B (zh) * | 2023-06-16 | 2024-10-15 | 安徽大学绿色产业创新研究院 | 一种假蜜环菌菌丝体均一多糖及其制备方法和应用 |
| CN117448350B (zh) * | 2023-10-18 | 2024-05-10 | 哈尔滨学院 | 一种利用桑黄Pb-bHLH9基因提高酿酒酵母多重胁迫抗性的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1915687C2 (de) * | 1968-03-28 | 1982-03-18 | Kaken Kagaku K.K., Tokyo | Pharmazeutisches Präparat mit Antitumorwirkung |
| CA968287A (en) * | 1968-10-08 | 1975-05-27 | Fumiko Fukuoka | Antitumor polysaccharides and preparation thereof |
-
0
- BE BE757248D patent/BE757248A/xx not_active IP Right Cessation
-
1969
- 1969-10-15 JP JP8181369A patent/JPS55363B1/ja active Pending
-
1970
- 1970-10-02 CA CA094,637A patent/CA983870A/en not_active Expired
- 1970-10-05 NL NL7014572A patent/NL7014572A/xx unknown
- 1970-10-14 GB GB4887070A patent/GB1331513A/en not_active Expired
- 1970-10-15 FR FR7037300A patent/FR2070133B1/fr not_active Expired
- 1970-10-15 DE DE2050714A patent/DE2050714C2/de not_active Expired
- 1970-10-15 CH CH1525470A patent/CH587345A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA983870A (en) | 1976-02-17 |
| DE2050714A1 (de) | 1971-04-22 |
| BE757248A (fr) | 1971-04-08 |
| JPS55363B1 (enrdf_load_html_response) | 1980-01-08 |
| CH587345A5 (enrdf_load_html_response) | 1977-04-29 |
| NL7014572A (enrdf_load_html_response) | 1971-04-19 |
| FR2070133B1 (enrdf_load_html_response) | 1975-03-14 |
| GB1331513A (en) | 1973-09-26 |
| FR2070133A1 (enrdf_load_html_response) | 1971-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |