DE2016484C3 - Verfahren zur Erhöhung der Wasserlöslichkeit von Mikrokapseln - Google Patents
Verfahren zur Erhöhung der Wasserlöslichkeit von MikrokapselnInfo
- Publication number
- DE2016484C3 DE2016484C3 DE2016484A DE2016484A DE2016484C3 DE 2016484 C3 DE2016484 C3 DE 2016484C3 DE 2016484 A DE2016484 A DE 2016484A DE 2016484 A DE2016484 A DE 2016484A DE 2016484 C3 DE2016484 C3 DE 2016484C3
- Authority
- DE
- Germany
- Prior art keywords
- microcapsules
- temperature
- enzyme
- increasing
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003094 microcapsule Substances 0.000 title claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 9
- 239000002775 capsule Substances 0.000 claims description 31
- 108091005804 Peptidases Proteins 0.000 claims description 7
- 102000035195 Peptidases Human genes 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 239000006185 dispersion Substances 0.000 claims description 5
- 230000015556 catabolic process Effects 0.000 claims description 4
- 238000006731 degradation reaction Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 description 25
- 108090000790 Enzymes Proteins 0.000 description 25
- 229940088598 enzyme Drugs 0.000 description 25
- 239000000243 solution Substances 0.000 description 13
- 108010010803 Gelatin Proteins 0.000 description 10
- 229920000159 gelatin Polymers 0.000 description 10
- 239000008273 gelatin Substances 0.000 description 10
- 235000019322 gelatine Nutrition 0.000 description 10
- 235000011852 gelatine desserts Nutrition 0.000 description 10
- 238000003756 stirring Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000004365 Protease Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 108090000526 Papain Proteins 0.000 description 4
- 102000057297 Pepsin A Human genes 0.000 description 4
- 108090000284 Pepsin A Proteins 0.000 description 4
- 235000019834 papain Nutrition 0.000 description 4
- 229940055729 papain Drugs 0.000 description 4
- 229940111202 pepsin Drugs 0.000 description 4
- 244000215068 Acacia senegal Species 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 230000009849 deactivation Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81482469A | 1969-04-09 | 1969-04-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2016484A1 DE2016484A1 (de) | 1970-10-22 |
| DE2016484B2 DE2016484B2 (de) | 1975-05-28 |
| DE2016484C3 true DE2016484C3 (de) | 1976-01-08 |
Family
ID=25216090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2016484A Expired DE2016484C3 (de) | 1969-04-09 | 1970-04-07 | Verfahren zur Erhöhung der Wasserlöslichkeit von Mikrokapseln |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3639259A (https=) |
| JP (1) | JPS5519610B1 (https=) |
| BE (1) | BE748629A (https=) |
| CA (1) | CA926328A (https=) |
| CH (1) | CH537212A (https=) |
| DE (1) | DE2016484C3 (https=) |
| FR (1) | FR2038337A1 (https=) |
| GB (1) | GB1252383A (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5115094B2 (https=) * | 1972-11-01 | 1976-05-14 | ||
| US4341215A (en) * | 1980-09-04 | 1982-07-27 | Tampax Incorporated | Absorbent device |
| US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
| GB2105728B (en) * | 1981-08-20 | 1984-08-30 | Malaysia Rubber Res Inst | Uses of natural rubber |
| DE3236389A1 (de) * | 1982-10-01 | 1984-04-05 | Bayer Ag, 5090 Leverkusen | Neue nucleosidverbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4803800A (en) * | 1987-03-27 | 1989-02-14 | Plant Genetics, Inc. | Synthetic substrate for filamentous fungi |
| CA2071867A1 (en) * | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
| US5932285A (en) * | 1995-02-17 | 1999-08-03 | Medlogic Global Corporation | Encapsulated materials |
| US5849412A (en) * | 1995-02-17 | 1998-12-15 | Medlogic Global Corporation | Encapsulated materials |
| JP3545148B2 (ja) * | 1996-01-08 | 2004-07-21 | 味の素株式会社 | 食用マイクロカプセル及びそれを含有する食品 |
| US6039901A (en) * | 1997-01-31 | 2000-03-21 | Givaudan Roure Flavors Corporation | Enzymatically protein encapsulating oil particles by complex coacervation |
| JP4381255B2 (ja) * | 2003-09-08 | 2009-12-09 | ソニーケミカル＆インフォメーションデバイス株式会社 | 潜在性硬化剤 |
| JP5146645B2 (ja) * | 2007-08-28 | 2013-02-20 | デクセリアルズ株式会社 | マイクロカプセル型潜在性硬化剤 |
| BR112013020410A2 (pt) * | 2011-02-11 | 2016-08-02 | Coating Supply Inc | promoção do desenvolvimento vegetal usando-se gelatina com base em colágeno |
| ITMI20111945A1 (it) * | 2011-10-26 | 2013-04-27 | Zapi Ind Chimiche Spa | Formulazione in forma idonea a veicolare un quantitativo dosato di una sostanza attiva |
| MA37469A1 (fr) | 2012-04-30 | 2016-04-29 | Dow Agrosciences Llc | Véhicules d'administration d'une composition de pesticide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US650760A (en) * | 1899-12-02 | 1900-05-29 | Frederick H Metcalf | Gelatin capsule. |
| US3089828A (en) * | 1960-12-27 | 1963-05-14 | Schwarz Biores Inc | Evaluation of proteolytic enzyme activity |
| US3324002A (en) * | 1962-09-17 | 1967-06-06 | Armour Pharma | Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids |
-
1969
- 1969-04-09 US US814824A patent/US3639259A/en not_active Expired - Lifetime
-
1970
- 1970-02-17 CA CA075103A patent/CA926328A/en not_active Expired
- 1970-03-12 GB GB1252383D patent/GB1252383A/en not_active Expired
- 1970-04-04 JP JP2897170A patent/JPS5519610B1/ja active Pending
- 1970-04-07 DE DE2016484A patent/DE2016484C3/de not_active Expired
- 1970-04-08 FR FR7012628A patent/FR2038337A1/fr not_active Withdrawn
- 1970-04-08 CH CH528170A patent/CH537212A/de not_active IP Right Cessation
- 1970-04-08 BE BE748629D patent/BE748629A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA926328A (en) | 1973-05-15 |
| GB1252383A (https=) | 1971-11-03 |
| DE2016484A1 (de) | 1970-10-22 |
| US3639259A (en) | 1972-02-01 |
| DE2016484B2 (de) | 1975-05-28 |
| BE748629A (fr) | 1970-09-16 |
| CH537212A (de) | 1973-05-31 |
| JPS5519610B1 (https=) | 1980-05-27 |
| FR2038337A1 (https=) | 1971-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |