DE2010116A1 - Verfahren zur Herstellung von Mikrogranulaten - Google Patents
Verfahren zur Herstellung von MikrogranulatenInfo
- Publication number
- DE2010116A1 DE2010116A1 DE19702010116 DE2010116A DE2010116A1 DE 2010116 A1 DE2010116 A1 DE 2010116A1 DE 19702010116 DE19702010116 DE 19702010116 DE 2010116 A DE2010116 A DE 2010116A DE 2010116 A1 DE2010116 A1 DE 2010116A1
- Authority
- DE
- Germany
- Prior art keywords
- particles
- solution
- water
- polymer
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 239000008187 granular material Substances 0.000 title claims description 5
- 239000002245 particle Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000011162 core material Substances 0.000 claims description 16
- 229920002678 cellulose Polymers 0.000 claims description 12
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 10
- 239000006185 dispersion Substances 0.000 claims description 9
- 229920000620 organic polymer Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 24
- 239000002904 solvent Substances 0.000 description 18
- 239000000126 substance Substances 0.000 description 15
- 239000012798 spherical particle Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000008346 aqueous phase Substances 0.000 description 7
- 239000002775 capsule Substances 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 230000002209 hydrophobic effect Effects 0.000 description 5
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
- 229940081735 acetylcellulose Drugs 0.000 description 4
- 229920002301 cellulose acetate Polymers 0.000 description 4
- -1 glycol ethers Chemical class 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical group CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 3
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical group CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 3
- 229960001138 acetylsalicylic acid Drugs 0.000 description 3
- 229920006218 cellulose propionate Polymers 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- UGZICOVULPINFH-UHFFFAOYSA-N acetic acid;butanoic acid Chemical compound CC(O)=O.CCCC(O)=O UGZICOVULPINFH-UHFFFAOYSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229920001727 cellulose butyrate Polymers 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 239000011164 primary particle Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- KNIUHBNRWZGIQQ-UHFFFAOYSA-N 7-diethoxyphosphinothioyloxy-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 KNIUHBNRWZGIQQ-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 150000001346 alkyl aryl ethers Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 150000001983 dialkylethers Chemical class 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- GKEMUBZAKCZMKO-UHFFFAOYSA-N ethane-1,2-diol;ethene Chemical group C=C.OCCO GKEMUBZAKCZMKO-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000012779 flatbread Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229920005613 synthetic organic polymer Polymers 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicinal Preparation (AREA)
- Lubricants (AREA)
- Adhesive Tapes (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702010116 DE2010116A1 (de) | 1970-03-04 | 1970-03-04 | Verfahren zur Herstellung von Mikrogranulaten |
| IL36222A IL36222A (en) | 1970-03-04 | 1971-02-17 | A process for the production of microgranulates |
| ZA711052A ZA711052B (en) | 1970-03-04 | 1971-02-18 | A process for the production of microgranulates |
| SU1627054A SU379074A1 (ru) | 1971-02-23 | еСЕСОЮЗНАЯ ПЛТ?НТйа-Т[Х1{!1'^?:СНАЯ1 | |
| AT173571A AT310127B (de) | 1970-03-04 | 1971-03-01 | Verfahren zur Umhüllung bzw. Einbettung von Feststoffteilchen oder Flüssigkeitströpfchen mit Celluloseestern bzw. in Celluloseestern |
| CA106615A CA922588A (en) | 1970-03-04 | 1971-03-02 | Process for the production of microgranulates |
| CH307871A CH549408A (de) | 1970-03-04 | 1971-03-03 | Verfahren zur herstellung von mikrogranulaten. |
| TR16847A TR16847A (tr) | 1970-03-04 | 1971-03-03 | Mikrogranuelatlarin yapilmasina mahsus usul |
| CS158871A CS158290B2 (enrdf_load_stackoverflow) | 1970-03-04 | 1971-03-03 | |
| ES388917A ES388917A1 (es) | 1970-03-04 | 1971-03-04 | Procedimiento para la produccion de microgranulado solido, esferico, de libre fluencia. |
| JP1101371A JPS5344424B1 (enrdf_load_stackoverflow) | 1970-03-04 | 1971-03-04 | |
| FR7107509A FR2084200A5 (enrdf_load_stackoverflow) | 1970-03-04 | 1971-03-04 | |
| BE763791A BE763791A (enrdf_load_stackoverflow) | 1970-03-04 | 1971-03-04 | |
| GB1297476D GB1297476A (enrdf_load_stackoverflow) | 1970-03-04 | 1971-04-19 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702010116 DE2010116A1 (de) | 1970-03-04 | 1970-03-04 | Verfahren zur Herstellung von Mikrogranulaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2010116A1 true DE2010116A1 (de) | 1971-09-16 |
Family
ID=5764038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702010116 Pending DE2010116A1 (de) | 1970-03-04 | 1970-03-04 | Verfahren zur Herstellung von Mikrogranulaten |
Country Status (13)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3306259A1 (de) * | 1980-11-14 | 1984-08-23 | Akademie Der Wissenschaften Der Ddr, Ddr 1199 Berlin | Mikrokapseln und verfahren zu ihrer herstellung |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE48715B1 (en) * | 1978-12-22 | 1985-05-01 | Elan Corp Plc | New galencial forms for administration of medicaments by oral route,with programmed release and processes for preparing same |
| US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| JP2534691B2 (ja) * | 1986-12-26 | 1996-09-18 | トツパン・ム−ア株式会社 | 高ち密性マイクロカプセルの製造方法 |
| JP2003526694A (ja) * | 1998-04-24 | 2003-09-09 | イーストマン ケミカル カンパニー | セルロースエステルと機能性添加剤との共沈及びそれによって得られる組成物 |
| EP1044683A1 (en) * | 1999-04-15 | 2000-10-18 | Debio Recherche Pharmaceutique S.A. | One-step dispersion method for the microencapsulation of water soluble substances |
| CN1189159C (zh) * | 2000-05-05 | 2005-02-16 | 欧莱雅 | 含水溶性美容活性组分水性核的微胶囊及含其的组合物 |
| AU2003292763A1 (en) * | 2003-12-24 | 2005-07-14 | Amato Pharmaceutical Products, Ltd. | Process for producing microsphere and apparatus for producing the same |
| GB201016436D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Method of making solid beads |
| GB201016433D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Apparatus and method for making solid beads |
| US20210244049A1 (en) * | 2018-06-15 | 2021-08-12 | Taminco Bvba | Treatment of poultry or pigs for reducing the feed conversion ratio or increasing their bodyweight gain |
-
1970
- 1970-03-04 DE DE19702010116 patent/DE2010116A1/de active Pending
-
1971
- 1971-02-17 IL IL36222A patent/IL36222A/xx unknown
- 1971-02-18 ZA ZA711052A patent/ZA711052B/xx unknown
- 1971-03-01 AT AT173571A patent/AT310127B/de not_active IP Right Cessation
- 1971-03-02 CA CA106615A patent/CA922588A/en not_active Expired
- 1971-03-03 CS CS158871A patent/CS158290B2/cs unknown
- 1971-03-03 CH CH307871A patent/CH549408A/xx not_active IP Right Cessation
- 1971-03-03 TR TR16847A patent/TR16847A/xx unknown
- 1971-03-04 ES ES388917A patent/ES388917A1/es not_active Expired
- 1971-03-04 JP JP1101371A patent/JPS5344424B1/ja active Pending
- 1971-03-04 FR FR7107509A patent/FR2084200A5/fr not_active Expired
- 1971-03-04 BE BE763791A patent/BE763791A/xx unknown
- 1971-04-19 GB GB1297476D patent/GB1297476A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3306259A1 (de) * | 1980-11-14 | 1984-08-23 | Akademie Der Wissenschaften Der Ddr, Ddr 1199 Berlin | Mikrokapseln und verfahren zu ihrer herstellung |
| DE3306259C2 (de) * | 1980-11-14 | 1998-07-09 | Dautzenberg Horst Dr | Mikrokapseln und Verfahren zu ihrer Herstellung |
Also Published As
| Publication number | Publication date |
|---|---|
| CA922588A (en) | 1973-03-13 |
| BE763791A (enrdf_load_stackoverflow) | 1971-08-02 |
| IL36222A (en) | 1973-08-29 |
| JPS5344424B1 (enrdf_load_stackoverflow) | 1978-11-29 |
| AT310127B (de) | 1973-09-25 |
| ZA711052B (en) | 1971-10-27 |
| IL36222A0 (en) | 1971-04-28 |
| CS158290B2 (enrdf_load_stackoverflow) | 1974-10-15 |
| SU379074A3 (enrdf_load_stackoverflow) | 1973-04-18 |
| TR16847A (tr) | 1973-07-01 |
| GB1297476A (enrdf_load_stackoverflow) | 1972-11-22 |
| ES388917A1 (es) | 1974-02-16 |
| FR2084200A5 (enrdf_load_stackoverflow) | 1971-12-17 |
| CH549408A (de) | 1974-05-31 |
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