DE19823834A1 - Genetisches Verfahren zur Herstellung von Riboflavin - Google Patents

Genetisches Verfahren zur Herstellung von Riboflavin

Info

Publication number
DE19823834A1
DE19823834A1 DE19823834A DE19823834A DE19823834A1 DE 19823834 A1 DE19823834 A1 DE 19823834A1 DE 19823834 A DE19823834 A DE 19823834A DE 19823834 A DE19823834 A DE 19823834A DE 19823834 A1 DE19823834 A1 DE 19823834A1
Authority
DE
Germany
Prior art keywords
genes
riboflavin
seq
synthase
organism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823834A
Other languages
German (de)
English (en)
Inventor
Henning Althoefer
Harald Seulberger
Oskar Zelder
Doval Jose Lui Revuelta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to DE19823834A priority Critical patent/DE19823834A1/de
Priority to AU41409/99A priority patent/AU4140999A/en
Priority to EP99924924A priority patent/EP1082438A2/de
Priority to IDW20002426A priority patent/ID27073A/id
Priority to PCT/EP1999/003196 priority patent/WO1999061623A2/de
Priority to RU2000133310/13A priority patent/RU2000133310A/ru
Priority to CN99806749A priority patent/CN1303434A/zh
Priority to KR1020007013352A priority patent/KR20010043867A/ko
Priority to JP2000551007A priority patent/JP2002516108A/ja
Publication of DE19823834A1 publication Critical patent/DE19823834A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DE19823834A 1998-05-28 1998-05-28 Genetisches Verfahren zur Herstellung von Riboflavin Withdrawn DE19823834A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE19823834A DE19823834A1 (de) 1998-05-28 1998-05-28 Genetisches Verfahren zur Herstellung von Riboflavin
AU41409/99A AU4140999A (en) 1998-05-28 1999-05-10 Genetic method for producing riboflavin
EP99924924A EP1082438A2 (de) 1998-05-28 1999-05-10 Genetisches verfahren zur herstellung von riboflavin
IDW20002426A ID27073A (id) 1998-05-28 1999-05-10 Proses genetik untuk menghasilkan riboflavin
PCT/EP1999/003196 WO1999061623A2 (de) 1998-05-28 1999-05-10 Genetisches verfahren zur herstellung von riboflavin
RU2000133310/13A RU2000133310A (ru) 1998-05-28 1999-05-10 Генетический способ получения рибофлавина
CN99806749A CN1303434A (zh) 1998-05-28 1999-05-10 用于生产核黄素的遗传方法
KR1020007013352A KR20010043867A (ko) 1998-05-28 1999-05-10 리보플라빈을 생산하는 유전적 방법
JP2000551007A JP2002516108A (ja) 1998-05-28 1999-05-10 リボフラビンの遺伝的製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823834A DE19823834A1 (de) 1998-05-28 1998-05-28 Genetisches Verfahren zur Herstellung von Riboflavin

Publications (1)

Publication Number Publication Date
DE19823834A1 true DE19823834A1 (de) 1999-12-02

Family

ID=7869161

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823834A Withdrawn DE19823834A1 (de) 1998-05-28 1998-05-28 Genetisches Verfahren zur Herstellung von Riboflavin

Country Status (9)

Country Link
EP (1) EP1082438A2 (en10)
JP (1) JP2002516108A (en10)
KR (1) KR20010043867A (en10)
CN (1) CN1303434A (en10)
AU (1) AU4140999A (en10)
DE (1) DE19823834A1 (en10)
ID (1) ID27073A (en10)
RU (1) RU2000133310A (en10)
WO (1) WO1999061623A2 (en10)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1702980A1 (en) 1999-07-01 2006-09-20 Basf Aktiengesellschaft Corynebacterium glutamicum gene encoding Hpr of phosphoenolpyruvate:sugar phosphotransferase system
EP1921151A1 (de) 2000-09-20 2008-05-14 Basf Se Verfahren zur Veränderung des Genoms von Corynebakterien
EP2272953A1 (en) 1999-07-01 2011-01-12 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum gene encoding phosphoenolpyruvate-protein phosphotransferase
EP2290062A1 (en) 1999-06-25 2011-03-02 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum gene encoding phosphoenolpyruvate carboxykinase

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1332207B1 (en) * 2000-07-14 2008-10-29 Archer-Daniels-Midland Company Transformation systems for flavinogenic yeast
US7009045B2 (en) 2000-07-14 2006-03-07 Archer-Daniels-Midland Company Transformation systems for flavinogenic yeast
ATE421577T1 (de) 2001-04-04 2009-02-15 Genencor Int Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
DE60229050D1 (de) 2001-04-04 2008-11-06 Genencor Int Verfahren zur herstellung von ascorbinsäurezwischenprodukten in wirtszellen
US20050118583A1 (en) * 2001-07-27 2005-06-02 Marvin Karos Novel genetic products of ashbya gossypii, associated with the mechanisms of signal transduction and especially with the improvement of vitamin b2 production
CA2457807A1 (en) * 2001-08-23 2003-03-06 Basf Aktiengesellschaft Ashbya gossypii enzymes
DE10159396A1 (de) * 2001-12-04 2003-06-12 Basf Ag Genetische Stammoptimierung zur verbesserten Herstellung von Riboflavin
DE10209363A1 (de) * 2002-03-02 2003-09-11 Basf Ag Verfahren zur Herstellung von Riboflavin
JP5565992B2 (ja) * 2005-09-28 2014-08-06 興人ライフサイエンス株式会社 酵母キャンディダ・ユティリスの形質転換法
JP5498651B2 (ja) * 2006-07-28 2014-05-21 花王株式会社 ジピコリン酸又はその塩の製造方法
CN104531745B (zh) * 2014-12-09 2018-05-04 江南大学 一种新型抗性质粒的构建及其在核黄素生产菌中的运用
CN113755551A (zh) * 2021-09-30 2021-12-07 天津科技大学 一种提高核黄素产量的发酵方法
CN114317557B (zh) * 2022-01-06 2023-07-07 河南农业大学 玉米ZmRIBA1基因在高赖氨酸玉米育种中的应用
CN116463305B (zh) * 2023-06-15 2023-10-17 北京易醒生物科技有限公司 一种提高用于乙醇氧化的醇氧化酶表达量的方法、优化的核黄素生物合成基因

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066486C (zh) * 1989-06-22 2001-05-30 霍夫曼-拉罗奇有限公司 高产核黄素的细菌菌株
WO1993004180A1 (de) * 1991-08-22 1993-03-04 Basf Aktiengesellschaft Verfahren zur gezielten genetischen veränderung von ashbya gossypii
EP0569806B1 (de) * 1992-05-11 2001-11-28 BASF Aktiengesellschaft DNA-Verbindungen und rekombinante, die Ribloflavinsynthetaseaktivität von S. cerevisiae codierende DNA-Expressionsvektoren
DE4420785A1 (de) * 1994-03-25 1995-10-05 Basf Ag Riboflavin-Biosynthese in Pilzen
DE59607050D1 (de) * 1995-07-13 2001-07-12 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von riboflavin mittels mikroorganismen mit veränderter isocitratlyase-aktivität
JPH1084978A (ja) * 1996-07-24 1998-04-07 F Hoffmann La Roche Ag 改良されたリボフラビン生産

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2290062A1 (en) 1999-06-25 2011-03-02 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum gene encoding phosphoenolpyruvate carboxykinase
EP2292763A1 (en) 1999-06-25 2011-03-09 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
EP1702980A1 (en) 1999-07-01 2006-09-20 Basf Aktiengesellschaft Corynebacterium glutamicum gene encoding Hpr of phosphoenolpyruvate:sugar phosphotransferase system
EP2272953A1 (en) 1999-07-01 2011-01-12 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum gene encoding phosphoenolpyruvate-protein phosphotransferase
EP1921151A1 (de) 2000-09-20 2008-05-14 Basf Se Verfahren zur Veränderung des Genoms von Corynebakterien

Also Published As

Publication number Publication date
ID27073A (id) 2001-02-22
RU2000133310A (ru) 2002-12-27
CN1303434A (zh) 2001-07-11
WO1999061623A2 (de) 1999-12-02
AU4140999A (en) 1999-12-13
WO1999061623A3 (de) 2000-01-27
KR20010043867A (ko) 2001-05-25
EP1082438A2 (de) 2001-03-14
JP2002516108A (ja) 2002-06-04

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