DE19818802A1 - Stabile Mitoxantron-Lösungen - Google Patents

Stabile Mitoxantron-Lösungen

Info

Publication number
DE19818802A1
DE19818802A1 DE19818802A DE19818802A DE19818802A1 DE 19818802 A1 DE19818802 A1 DE 19818802A1 DE 19818802 A DE19818802 A DE 19818802A DE 19818802 A DE19818802 A DE 19818802A DE 19818802 A1 DE19818802 A1 DE 19818802A1
Authority
DE
Germany
Prior art keywords
sodium
solution
mitoxantrone
stable
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19818802A
Other languages
German (de)
English (en)
Inventor
Katrin Moschner
Mario Weingart
Michael Pieroth
Wolfgang Morick
Elisabeth Wolf-Heuss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Priority to DE19818802A priority Critical patent/DE19818802A1/de
Priority to NZ507407A priority patent/NZ507407A/xx
Priority to HU0102075A priority patent/HUP0102075A3/hu
Priority to DE59911099T priority patent/DE59911099D1/de
Priority to AT99916906T priority patent/ATE282431T1/de
Priority to AU35225/99A priority patent/AU744502B2/en
Priority to RU2000129666/14A priority patent/RU2219917C2/ru
Priority to EP99916906A priority patent/EP1073469B1/fr
Priority to BR9909981-0A priority patent/BR9909981A/pt
Priority to CNB998055794A priority patent/CN1195548C/zh
Priority to JP2000545572A priority patent/JP2002512981A/ja
Priority to PCT/EP1999/002290 priority patent/WO1999055375A1/fr
Priority to CO99020294A priority patent/CO5021217A1/es
Priority to TW088106569A priority patent/TWI224003B/zh
Priority to CA002270004A priority patent/CA2270004C/fr
Priority to US09/299,131 priority patent/US6143795A/en
Priority to ARP990101932A priority patent/AR018198A1/es
Publication of DE19818802A1 publication Critical patent/DE19818802A1/de
Priority to BG104850A priority patent/BG64767B1/bg
Priority to HK01106731A priority patent/HK1036012A1/xx
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19818802A 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen Ceased DE19818802A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE19818802A DE19818802A1 (de) 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen
CNB998055794A CN1195548C (zh) 1998-04-27 1999-04-01 稳定的米托蒽醌溶液
JP2000545572A JP2002512981A (ja) 1998-04-27 1999-04-01 安定なミトキサントロン−溶液
DE59911099T DE59911099D1 (de) 1998-04-27 1999-04-01 Stabile mitoxantron-lösungen
AT99916906T ATE282431T1 (de) 1998-04-27 1999-04-01 Stabile mitoxantron-lösungen
AU35225/99A AU744502B2 (en) 1998-04-27 1999-04-01 Stable mitoxantron solutions
RU2000129666/14A RU2219917C2 (ru) 1998-04-27 1999-04-01 Стабильные растворы митоксантрона
EP99916906A EP1073469B1 (fr) 1998-04-27 1999-04-01 Solutions stables de mitoxantrone
BR9909981-0A BR9909981A (pt) 1998-04-27 1999-04-01 Soluções de mitoxantrona estáveis
NZ507407A NZ507407A (en) 1998-04-27 1999-04-01 Stable mitoxantrone solutions
HU0102075A HUP0102075A3 (en) 1998-04-27 1999-04-01 Stable mitoxantron solutions, process for their preparation
PCT/EP1999/002290 WO1999055375A1 (fr) 1998-04-27 1999-04-01 Solutions stables de mitoxantrone
CO99020294A CO5021217A1 (es) 1998-04-27 1999-04-07 Composiciones estables de mitoxantrona, procedimietno para prepararlas; utilizacion de dichas composiciones y medica- mentos que incluyen dichas soluciones para el tratamiento de enfermedades cancerosas
TW088106569A TWI224003B (en) 1998-04-27 1999-04-23 Stable mitoxantrone solutions
CA002270004A CA2270004C (fr) 1998-04-27 1999-04-26 Solutions de mitoxantrone stables
US09/299,131 US6143795A (en) 1998-04-27 1999-04-26 Stable mitoxantrone solutions
ARP990101932A AR018198A1 (es) 1998-04-27 1999-04-27 Soluciones estables de mitoxantrona, procedimiento para prepararlas, utilizacion de dichas soluciones para la preparacion de medicamentos y losmedicamentos de aplicacion de dichas soluciones para el tratamiento de enfermedades cancerosas
BG104850A BG64767B1 (bg) 1998-04-27 2000-10-12 Устойчиви разтвори на митоксантрон
HK01106731A HK1036012A1 (en) 1998-04-27 2001-09-24 Stable mitoxantron solutions.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19818802A DE19818802A1 (de) 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen

Publications (1)

Publication Number Publication Date
DE19818802A1 true DE19818802A1 (de) 1999-10-28

Family

ID=7865948

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19818802A Ceased DE19818802A1 (de) 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen
DE59911099T Expired - Fee Related DE59911099D1 (de) 1998-04-27 1999-04-01 Stabile mitoxantron-lösungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59911099T Expired - Fee Related DE59911099D1 (de) 1998-04-27 1999-04-01 Stabile mitoxantron-lösungen

Country Status (18)

Country Link
US (1) US6143795A (fr)
EP (1) EP1073469B1 (fr)
JP (1) JP2002512981A (fr)
CN (1) CN1195548C (fr)
AR (1) AR018198A1 (fr)
AT (1) ATE282431T1 (fr)
AU (1) AU744502B2 (fr)
BG (1) BG64767B1 (fr)
BR (1) BR9909981A (fr)
CA (1) CA2270004C (fr)
CO (1) CO5021217A1 (fr)
DE (2) DE19818802A1 (fr)
HK (1) HK1036012A1 (fr)
HU (1) HUP0102075A3 (fr)
NZ (1) NZ507407A (fr)
RU (1) RU2219917C2 (fr)
TW (1) TWI224003B (fr)
WO (1) WO1999055375A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
DK2368553T3 (en) 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
CN102397561B (zh) * 2011-09-26 2013-03-06 沈阳药科大学 米托蒽醌作为淋巴示踪剂的应用
JP5589110B1 (ja) * 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
CN107149592B (zh) * 2017-06-23 2019-10-08 沈阳天邦药业有限公司 具有淋巴靶向功能的生物自组装纳米晶注射剂及制备方法
CN113730603B (zh) * 2020-05-27 2023-01-24 深圳华润九创医药有限公司 米托蒽醌制剂在制备诊治与甲状腺切除相关的疾病的药物中的应用
CN114601791B (zh) * 2020-12-08 2023-09-19 成都倍特药业股份有限公司 一种盐酸米托蒽醌液体制剂及其制备方法
CN114732807A (zh) * 2022-03-27 2022-07-12 苏州大学 米托蒽醌在制备预防或治疗急性移植物抗宿主病药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236822A2 (fr) * 1986-03-07 1987-09-16 American Cyanamid Company Formulation pharmaceutique injectable stable à base du dichlorhydrate de la 1,4-dihydroxy-5,8-bis((2-(hydroxyéthylamino)-éthyl)amino)anthraquinone
DE3825374C2 (fr) * 1988-07-26 1990-06-28 Reto Dipl.-Apotheker Dr.Sc.Nat. Kilchberg Ch Schwendener
FR2758264A1 (fr) * 1997-01-16 1998-07-17 Charles Dumontet Compositions medicamenteuses contenant de l'edta ou un de ses derives pour la prevention de la toxicite cutanee et sous-cutanee des anthracyclines et de leurs derives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248291A (en) * 1963-08-19 1966-04-26 Hoffmann La Roche Stabilized thioxanthene derivatives and method of using the same
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
WO1994013274A1 (fr) * 1992-12-10 1994-06-23 Abbott Laboratories Solutions de catecholamines stabilisees

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236822A2 (fr) * 1986-03-07 1987-09-16 American Cyanamid Company Formulation pharmaceutique injectable stable à base du dichlorhydrate de la 1,4-dihydroxy-5,8-bis((2-(hydroxyéthylamino)-éthyl)amino)anthraquinone
DE3825374C2 (fr) * 1988-07-26 1990-06-28 Reto Dipl.-Apotheker Dr.Sc.Nat. Kilchberg Ch Schwendener
FR2758264A1 (fr) * 1997-01-16 1998-07-17 Charles Dumontet Compositions medicamenteuses contenant de l'edta ou un de ses derives pour la prevention de la toxicite cutanee et sous-cutanee des anthracyclines et de leurs derives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FIEDLER,Herbert P.: Lexikon der Hilfsstoffe für Pharmazie, Kosmetik und angrenzende Gebiete, Editio Cantor, Aulendorf, 1989, S.468-471 *
WPIDS Abstract, Ref. 98-269960/24 zu RU 2093158 C1 *

Also Published As

Publication number Publication date
CN1195548C (zh) 2005-04-06
HUP0102075A3 (en) 2002-10-28
JP2002512981A (ja) 2002-05-08
NZ507407A (en) 2002-08-28
AU744502B2 (en) 2002-02-28
EP1073469A1 (fr) 2001-02-07
CO5021217A1 (es) 2001-03-27
CA2270004C (fr) 2004-06-01
EP1073469B1 (fr) 2004-11-17
DE59911099D1 (de) 2004-12-23
US6143795A (en) 2000-11-07
BG104850A (en) 2001-05-31
HK1036012A1 (en) 2001-12-21
AU3522599A (en) 1999-11-16
BG64767B1 (bg) 2006-03-31
CN1298310A (zh) 2001-06-06
BR9909981A (pt) 2000-12-26
WO1999055375A1 (fr) 1999-11-04
ATE282431T1 (de) 2004-12-15
HUP0102075A2 (hu) 2002-05-29
CA2270004A1 (fr) 1999-10-27
AR018198A1 (es) 2001-10-31
RU2219917C2 (ru) 2003-12-27
TWI224003B (en) 2004-11-21

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8127 New person/name/address of the applicant

Owner name: BAXTER HEALTHCARE S.A., WALLISELLEN, CH

8110 Request for examination paragraph 44
8131 Rejection