HUP0102075A2 - Stabil mitoxantron-oldatok, eljárás az előállításukra - Google Patents

Stabil mitoxantron-oldatok, eljárás az előállításukra

Info

Publication number
HUP0102075A2
HUP0102075A2 HU0102075A HUP0102075A HUP0102075A2 HU P0102075 A2 HUP0102075 A2 HU P0102075A2 HU 0102075 A HU0102075 A HU 0102075A HU P0102075 A HUP0102075 A HU P0102075A HU P0102075 A2 HUP0102075 A2 HU P0102075A2
Authority
HU
Hungary
Prior art keywords
stable
preparation
solutions
mitoxantrone
mitoxantron
Prior art date
Application number
HU0102075A
Other languages
English (en)
Inventor
Wolfgang Morick
Katrin Moschner
Michael Pieroth
Mario Weingart
Elisabeth Wolf-Heuss
Original Assignee
Arzneimittelwerk Dresden Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh
Publication of HUP0102075A2 publication Critical patent/HUP0102075A2/hu
Publication of HUP0102075A3 publication Critical patent/HUP0102075A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány mitoxantron-oldatokra vonatkozik, amelyek a mitoxantronhatóanyag {1,4-dihidro-5,8-bisz[[2-[(2-hidroxietil)-amino)etil]-amino]-antrakinon-hidroklorid} mellett stabilizátort tartalmaznak ésszulfit-vegyületektől mentesek. A találmány szerinti mitoxantron-oldatok stabilizátorként 0,001-0,15 % nátrium-edetátot tartalmaznak. Ó
HU0102075A 1998-04-27 1999-04-01 Stable mitoxantron solutions, process for their preparation HUP0102075A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19818802A DE19818802A1 (de) 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen

Publications (2)

Publication Number Publication Date
HUP0102075A2 true HUP0102075A2 (hu) 2002-05-29
HUP0102075A3 HUP0102075A3 (en) 2002-10-28

Family

ID=7865948

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102075A HUP0102075A3 (en) 1998-04-27 1999-04-01 Stable mitoxantron solutions, process for their preparation

Country Status (18)

Country Link
US (1) US6143795A (hu)
EP (1) EP1073469B1 (hu)
JP (1) JP2002512981A (hu)
CN (1) CN1195548C (hu)
AR (1) AR018198A1 (hu)
AT (1) ATE282431T1 (hu)
AU (1) AU744502B2 (hu)
BG (1) BG64767B1 (hu)
BR (1) BR9909981A (hu)
CA (1) CA2270004C (hu)
CO (1) CO5021217A1 (hu)
DE (2) DE19818802A1 (hu)
HK (1) HK1036012A1 (hu)
HU (1) HUP0102075A3 (hu)
NZ (1) NZ507407A (hu)
RU (1) RU2219917C2 (hu)
TW (1) TWI224003B (hu)
WO (1) WO1999055375A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
EP1615646B2 (en) 2003-04-08 2022-07-27 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
CN102397561B (zh) * 2011-09-26 2013-03-06 沈阳药科大学 米托蒽醌作为淋巴示踪剂的应用
JP5589110B1 (ja) * 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
CN107149592B (zh) * 2017-06-23 2019-10-08 沈阳天邦药业有限公司 具有淋巴靶向功能的生物自组装纳米晶注射剂及制备方法
CN113730603B (zh) * 2020-05-27 2023-01-24 深圳华润九创医药有限公司 米托蒽醌制剂在制备诊治与甲状腺切除相关的疾病的药物中的应用
CN114601791B (zh) * 2020-12-08 2023-09-19 成都倍特药业股份有限公司 一种盐酸米托蒽醌液体制剂及其制备方法
CN114732807A (zh) * 2022-03-27 2022-07-12 苏州大学 米托蒽醌在制备预防或治疗急性移植物抗宿主病药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248291A (en) * 1963-08-19 1966-04-26 Hoffmann La Roche Stabilized thioxanthene derivatives and method of using the same
ES2033247T3 (es) * 1986-03-07 1993-03-16 American Cyanamid Company Metodo para preparar una composicion farmaceutica a base de un compuesto antraquinonico.
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
DE3825374A1 (de) * 1988-07-26 1990-02-01 Schwendener Reto Dipl Apotheke Komplex aus mindestens einer lipophilen saeure und mitoxantron und/oder bisantren
WO1994013274A1 (en) * 1992-12-10 1994-06-23 Abbott Laboratories Stabilized catecholamine solutions
FR2758264B1 (fr) * 1997-01-16 1999-03-26 Charles Dumontet Compositions medicamenteuses contenant de l'edta ou un de ses derives pour la prevention de la toxicite cutanee et sous-cutanee des anthracyclines et de leurs derives

Also Published As

Publication number Publication date
CA2270004A1 (en) 1999-10-27
WO1999055375A1 (de) 1999-11-04
AU3522599A (en) 1999-11-16
JP2002512981A (ja) 2002-05-08
AR018198A1 (es) 2001-10-31
RU2219917C2 (ru) 2003-12-27
CN1298310A (zh) 2001-06-06
CN1195548C (zh) 2005-04-06
NZ507407A (en) 2002-08-28
CA2270004C (en) 2004-06-01
AU744502B2 (en) 2002-02-28
TWI224003B (en) 2004-11-21
EP1073469B1 (de) 2004-11-17
HK1036012A1 (en) 2001-12-21
BR9909981A (pt) 2000-12-26
CO5021217A1 (es) 2001-03-27
BG64767B1 (bg) 2006-03-31
US6143795A (en) 2000-11-07
DE19818802A1 (de) 1999-10-28
DE59911099D1 (de) 2004-12-23
BG104850A (en) 2001-05-31
ATE282431T1 (de) 2004-12-15
EP1073469A1 (de) 2001-02-07
HUP0102075A3 (en) 2002-10-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees