AR018198A1 - Soluciones estables de mitoxantrona, procedimiento para prepararlas, utilizacion de dichas soluciones para la preparacion de medicamentos y losmedicamentos de aplicacion de dichas soluciones para el tratamiento de enfermedades cancerosas - Google Patents

Soluciones estables de mitoxantrona, procedimiento para prepararlas, utilizacion de dichas soluciones para la preparacion de medicamentos y losmedicamentos de aplicacion de dichas soluciones para el tratamiento de enfermedades cancerosas

Info

Publication number
AR018198A1
AR018198A1 ARP990101932A ARP990101932A AR018198A1 AR 018198 A1 AR018198 A1 AR 018198A1 AR P990101932 A ARP990101932 A AR P990101932A AR P990101932 A ARP990101932 A AR P990101932A AR 018198 A1 AR018198 A1 AR 018198A1
Authority
AR
Argentina
Prior art keywords
solutions
mitoxantrone
medicines
procedure
preparation
Prior art date
Application number
ARP990101932A
Other languages
English (en)
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of AR018198A1 publication Critical patent/AR018198A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Soluciones estables de mitoxantrona que comprenden 1 a 5 mg/ml de solucion de clorhidrato de mitoxantrona, de 0,001 a 0,15% de edetato de sodio y,además como componentes adicionales: cloruro de sodio, acetato de sodio y ácido acético. Dichas soluciones están exentas de compuestos de sulfitoevitándose los efectos secundarios de su aplicacion parenteral. El procedimiento para preparar dichas soluciones, la utilizacion de las mismaspara la preparacion de medicamentos anticancerosos y los medicamentos para el tratamiento del cáncer que utilizan dichas soluciones. Las solucionesestables de mitoxantrona son muy utiles en terapéutica puesto que la mitoxantrona es un compuesto que manifiesta propiedades antineoplásicas, antivirales,antiprotozoalese inmunomoduladoras.
ARP990101932A 1998-04-27 1999-04-27 Soluciones estables de mitoxantrona, procedimiento para prepararlas, utilizacion de dichas soluciones para la preparacion de medicamentos y losmedicamentos de aplicacion de dichas soluciones para el tratamiento de enfermedades cancerosas AR018198A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19818802A DE19818802A1 (de) 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen

Publications (1)

Publication Number Publication Date
AR018198A1 true AR018198A1 (es) 2001-10-31

Family

ID=7865948

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101932A AR018198A1 (es) 1998-04-27 1999-04-27 Soluciones estables de mitoxantrona, procedimiento para prepararlas, utilizacion de dichas soluciones para la preparacion de medicamentos y losmedicamentos de aplicacion de dichas soluciones para el tratamiento de enfermedades cancerosas

Country Status (18)

Country Link
US (1) US6143795A (es)
EP (1) EP1073469B1 (es)
JP (1) JP2002512981A (es)
CN (1) CN1195548C (es)
AR (1) AR018198A1 (es)
AT (1) ATE282431T1 (es)
AU (1) AU744502B2 (es)
BG (1) BG64767B1 (es)
BR (1) BR9909981A (es)
CA (1) CA2270004C (es)
CO (1) CO5021217A1 (es)
DE (2) DE19818802A1 (es)
HK (1) HK1036012A1 (es)
HU (1) HUP0102075A3 (es)
NZ (1) NZ507407A (es)
RU (1) RU2219917C2 (es)
TW (1) TWI224003B (es)
WO (1) WO1999055375A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
DK2368553T3 (en) 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
CN102397561B (zh) * 2011-09-26 2013-03-06 沈阳药科大学 米托蒽醌作为淋巴示踪剂的应用
JP5589110B1 (ja) * 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
CN107149592B (zh) * 2017-06-23 2019-10-08 沈阳天邦药业有限公司 具有淋巴靶向功能的生物自组装纳米晶注射剂及制备方法
CN113730603B (zh) * 2020-05-27 2023-01-24 深圳华润九创医药有限公司 米托蒽醌制剂在制备诊治与甲状腺切除相关的疾病的药物中的应用
CN114601791B (zh) * 2020-12-08 2023-09-19 成都倍特药业股份有限公司 一种盐酸米托蒽醌液体制剂及其制备方法
CN114732807A (zh) * 2022-03-27 2022-07-12 苏州大学 米托蒽醌在制备预防或治疗急性移植物抗宿主病药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248291A (en) * 1963-08-19 1966-04-26 Hoffmann La Roche Stabilized thioxanthene derivatives and method of using the same
ATE59290T1 (de) * 1986-03-07 1991-01-15 American Cyanamid Co Stabile injizierbare arzneiformulierung des 1,4- dihydroxy-5,8-bis((2-(hydroxyaethylamino)|thyl)amino)anthrachinondihydrochlorids.
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
DE3825374A1 (de) * 1988-07-26 1990-02-01 Schwendener Reto Dipl Apotheke Komplex aus mindestens einer lipophilen saeure und mitoxantron und/oder bisantren
WO1994013274A1 (en) * 1992-12-10 1994-06-23 Abbott Laboratories Stabilized catecholamine solutions
FR2758264B1 (fr) * 1997-01-16 1999-03-26 Charles Dumontet Compositions medicamenteuses contenant de l'edta ou un de ses derives pour la prevention de la toxicite cutanee et sous-cutanee des anthracyclines et de leurs derives

Also Published As

Publication number Publication date
CN1195548C (zh) 2005-04-06
HUP0102075A3 (en) 2002-10-28
JP2002512981A (ja) 2002-05-08
NZ507407A (en) 2002-08-28
DE19818802A1 (de) 1999-10-28
AU744502B2 (en) 2002-02-28
EP1073469A1 (de) 2001-02-07
CO5021217A1 (es) 2001-03-27
CA2270004C (en) 2004-06-01
EP1073469B1 (de) 2004-11-17
DE59911099D1 (de) 2004-12-23
US6143795A (en) 2000-11-07
BG104850A (en) 2001-05-31
HK1036012A1 (en) 2001-12-21
AU3522599A (en) 1999-11-16
BG64767B1 (bg) 2006-03-31
CN1298310A (zh) 2001-06-06
BR9909981A (pt) 2000-12-26
WO1999055375A1 (de) 1999-11-04
ATE282431T1 (de) 2004-12-15
HUP0102075A2 (hu) 2002-05-29
CA2270004A1 (en) 1999-10-27
RU2219917C2 (ru) 2003-12-27
TWI224003B (en) 2004-11-21

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