DE19726282A1 - Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern - Google Patents
Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen KernInfo
- Publication number
- DE19726282A1 DE19726282A1 DE19726282A DE19726282A DE19726282A1 DE 19726282 A1 DE19726282 A1 DE 19726282A1 DE 19726282 A DE19726282 A DE 19726282A DE 19726282 A DE19726282 A DE 19726282A DE 19726282 A1 DE19726282 A1 DE 19726282A1
- Authority
- DE
- Germany
- Prior art keywords
- nanoscale particles
- shell
- particles according
- core
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 43
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 239000002245 particle Substances 0.000 claims abstract description 57
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 29
- 230000007935 neutral effect Effects 0.000 claims abstract description 14
- 241000894007 species Species 0.000 claims abstract description 10
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 125000002091 cationic group Chemical group 0.000 claims abstract description 7
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 6
- 206010020843 Hyperthermia Diseases 0.000 claims abstract description 4
- 230000036031 hyperthermia Effects 0.000 claims abstract description 4
- 125000000129 anionic group Chemical group 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims description 16
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- 125000003277 amino group Chemical group 0.000 claims description 10
- 239000011553 magnetic fluid Substances 0.000 claims description 8
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 7
- FZHAPNGMFPVSLP-UHFFFAOYSA-N silanamine Chemical class [SiH3]N FZHAPNGMFPVSLP-UHFFFAOYSA-N 0.000 claims description 6
- 229920002307 Dextran Polymers 0.000 claims description 5
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- 229940044683 chemotherapy drug Drugs 0.000 claims description 3
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 3
- 150000004756 silanes Chemical class 0.000 claims description 3
- 230000009089 cytolysis Effects 0.000 claims description 2
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- 235000013980 iron oxide Nutrition 0.000 description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
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- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
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- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- ZDZYGYFHTPFREM-UHFFFAOYSA-N 3-[3-aminopropyl(dimethoxy)silyl]oxypropan-1-amine Chemical compound NCCC[Si](OC)(OC)OCCCN ZDZYGYFHTPFREM-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
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- 102000004310 Ion Channels Human genes 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
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- 229920000954 Polyglycolide Polymers 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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- 230000006538 anaerobic glycolysis Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910001566 austenite Inorganic materials 0.000 description 1
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- 230000021164 cell adhesion Effects 0.000 description 1
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- 210000004517 glycocalyx Anatomy 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- -1 iron ions Chemical class 0.000 description 1
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- AMVXVPUHCLLJRE-UHFFFAOYSA-N n'-(3-trimethoxysilylpropyl)hexane-1,6-diamine Chemical compound CO[Si](OC)(OC)CCCNCCCCCCN AMVXVPUHCLLJRE-UHFFFAOYSA-N 0.000 description 1
- NHBRUUFBSBSTHM-UHFFFAOYSA-N n'-[2-(3-trimethoxysilylpropylamino)ethyl]ethane-1,2-diamine Chemical compound CO[Si](OC)(OC)CCCNCCNCCN NHBRUUFBSBSTHM-UHFFFAOYSA-N 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
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- 230000020477 pH reduction Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hard Magnetic Materials (AREA)
- Compounds Of Iron (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19726282A DE19726282A1 (de) | 1997-06-20 | 1997-06-20 | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| US09/446,438 US6541039B1 (en) | 1997-06-20 | 1998-06-19 | Nanoscale particles having an iron oxide-containing core enveloped by at least two shells |
| DK98939520T DK1001811T3 (da) | 1997-06-20 | 1998-06-19 | Nanopartikler med en jernoxidholdig kerne omgivet af mindst to skaller |
| EP98939520A EP1001811B1 (de) | 1997-06-20 | 1998-06-19 | Nanoskalige teilchen mit einem von mindestens zwei schalen umgebenen eisenoxid-haltigen kern |
| JP50378399A JP4902900B2 (ja) | 1997-06-20 | 1998-06-19 | 少なくとも２つのシェルに包まれた酸化鉄含有コアを有するナノスケール粒子 |
| CNB988063018A CN1211127C (zh) | 1997-06-20 | 1998-06-19 | 具有至少两层包壳的含氧化铁芯的纳米级颗粒 |
| DE59805535T DE59805535D1 (de) | 1997-06-20 | 1998-06-19 | Nanoskalige teilchen mit einem von mindestens zwei schalen umgebenen eisenoxid-haltigen kern |
| PT98939520T PT1001811E (pt) | 1997-06-20 | 1998-06-19 | Particulas a nanoescala com um nucleo contendo oxido de ferro envolvido por pelo menos duas capsulas |
| ES98939520T ES2181256T3 (es) | 1997-06-20 | 1998-06-19 | Particulas de tamaño nanometrico con un nucleo de oxido de hierro rodeado por al menos dos cortezas. |
| PCT/EP1998/003761 WO1998058673A1 (de) | 1997-06-20 | 1998-06-19 | Nanoskalige teilchen mit einem von mindestens zwei schalen umgebenen eisenoxid-haltigen kern |
| AT98939520T ATE223731T1 (de) | 1997-06-20 | 1998-06-19 | Nanoskalige teilchen mit einem von mindestens zwei schalen umgebenen eisenoxid-haltigen kern |
| US10/391,356 US6979466B2 (en) | 1997-06-20 | 2003-03-17 | Nanoscale particles having an iron oxide-containing core enveloped by at least two shells |
| JP2009210228A JP5116743B2 (ja) | 1997-06-20 | 2009-09-11 | 少なくとも２つのシェルに包まれた酸化鉄含有コアを有するナノスケール粒子 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19726282A DE19726282A1 (de) | 1997-06-20 | 1997-06-20 | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19726282A1 true DE19726282A1 (de) | 1998-12-24 |
Family
ID=7833178
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19726282A Withdrawn DE19726282A1 (de) | 1997-06-20 | 1997-06-20 | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| DE59805535T Expired - Lifetime DE59805535D1 (de) | 1997-06-20 | 1998-06-19 | Nanoskalige teilchen mit einem von mindestens zwei schalen umgebenen eisenoxid-haltigen kern |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59805535T Expired - Lifetime DE59805535D1 (de) | 1997-06-20 | 1998-06-19 | Nanoskalige teilchen mit einem von mindestens zwei schalen umgebenen eisenoxid-haltigen kern |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6541039B1 (enExample) |
| EP (1) | EP1001811B1 (enExample) |
| JP (2) | JP4902900B2 (enExample) |
| CN (1) | CN1211127C (enExample) |
| AT (1) | ATE223731T1 (enExample) |
| DE (2) | DE19726282A1 (enExample) |
| DK (1) | DK1001811T3 (enExample) |
| ES (1) | ES2181256T3 (enExample) |
| PT (1) | PT1001811E (enExample) |
| WO (1) | WO1998058673A1 (enExample) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19921088A1 (de) * | 1999-04-30 | 2000-11-02 | Andreas Jordan | Stent zur Offenhaltung gangartiger Strukturen |
| DE19940220A1 (de) * | 1999-08-19 | 2001-02-22 | Andreas Jordan | Medizinisches Präparat zur Behandlung von Arthrose, Arthritis und anderen rheumatischen Gelenkerkrankungen |
| DE10020376A1 (de) * | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
| WO2002018499A1 (de) | 2000-09-01 | 2002-03-07 | Henkel Kommanditgesellschaft Auk Aktien | Reaktionsklebstoff mit mindestens einer mikroverkapselten komponente |
| DE10205332A1 (de) * | 2002-02-06 | 2003-08-28 | Berlin Heart Ag | Verfahren zur Herstellung von magnetischen Nanoteilchen |
| US6855760B1 (en) | 1999-05-26 | 2005-02-15 | Henkel Kommanditgesellschaft Auf Aktien | Detachable adhesive compounds |
| US7147742B2 (en) | 2000-08-03 | 2006-12-12 | Henkel Kommanditgesellschaft Auf Aktien ( Henkel Kgaa) | Method for accelerating the curing of adhesives |
| WO2007019845A3 (de) * | 2005-08-19 | 2007-04-19 | Magforce Nanotechnologies Ag | Verfahren zur einschleusung von therapeutischen substanzen in zellen |
| US7273580B2 (en) | 2000-08-03 | 2007-09-25 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Ferromagnetic resonance excitation and its use for heating substrates that are filled with particles |
| US7407704B2 (en) | 1999-10-27 | 2008-08-05 | Henkel Kgaa | Process for adhesive separation of bonded joints |
| US7479288B2 (en) | 2001-12-21 | 2009-01-20 | Henkel Kommanditgesellschaft Auf Aktien | Nanoparticulate preparation |
| EP2269664A2 (de) | 2007-01-21 | 2011-01-05 | Hemoteq AG | Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse |
| WO2013021039A1 (en) | 2011-08-11 | 2013-02-14 | Basf Se | Microwave absorbing composition |
| DE102016006320A1 (de) | 2016-05-25 | 2017-11-30 | Carl Freudenberg Kg | Fixierbare Flächengebilde |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19726282A1 (de) * | 1997-06-20 | 1998-12-24 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| DE50015289D1 (de) * | 1999-08-24 | 2008-09-11 | Henkel Ag & Co Kgaa | Verklebung durch Klebstoffe enthaltend nanoskalige Teilchen |
| EP2343047B2 (en) | 2000-02-08 | 2021-03-17 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US6997863B2 (en) * | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US7074175B2 (en) * | 2001-07-25 | 2006-07-11 | Erik Schroeder Handy | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US7951061B2 (en) * | 2001-07-25 | 2011-05-31 | Allan Foreman | Devices for targeted delivery of thermotherapy, and methods related thereto |
| US7731648B2 (en) * | 2001-07-25 | 2010-06-08 | Aduro Biotech | Magnetic nanoscale particle compositions, and therapeutic methods related thereto |
| US20050013875A1 (en) * | 2001-10-25 | 2005-01-20 | Takeshi Kobayashi | Immunopotentiators in thermotherapy for cancer |
| AU2002361032A1 (en) * | 2002-12-09 | 2004-06-30 | Itn-Nanovation Gmbh | Nanoscale core/shell particles and the production thereof |
| AU2003900335A0 (en) * | 2003-01-22 | 2003-02-13 | Sirtex Medical Limited | Microparticles for selectively targeted hyperthermia |
| DE10331439B3 (de) | 2003-07-10 | 2005-02-03 | Micromod Partikeltechnologie Gmbh | Magnetische Nanopartikel mit verbesserten Magneteigenschaften |
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| DE19921088A1 (de) * | 1999-04-30 | 2000-11-02 | Andreas Jordan | Stent zur Offenhaltung gangartiger Strukturen |
| WO2000066192A1 (de) * | 1999-04-30 | 2000-11-09 | Magforce Applications Gmbh | Stent zur offenhaltung gangartiger strukturen |
| DE19921088C2 (de) * | 1999-04-30 | 2003-08-07 | Magforce Applic Gmbh | Stent zur Offenhaltung gangartiger Strukturen |
| US6808535B1 (en) | 1999-04-30 | 2004-10-26 | Magforce Applications Gmbh | Stent for keeping open tubular structures |
| EP1785462A1 (de) | 1999-05-26 | 2007-05-16 | Henkel Kommanditgesellschaft Auf Aktien | Lösbare Klebeverbindungen |
| US6855760B1 (en) | 1999-05-26 | 2005-02-15 | Henkel Kommanditgesellschaft Auf Aktien | Detachable adhesive compounds |
| DE19940220A1 (de) * | 1999-08-19 | 2001-02-22 | Andreas Jordan | Medizinisches Präparat zur Behandlung von Arthrose, Arthritis und anderen rheumatischen Gelenkerkrankungen |
| WO2001013949A3 (de) * | 1999-08-19 | 2001-12-20 | Magforce Applic Gmbh | Medizinisches präparat zur behandlung von arthrose, arthritis und anderen rheumatischen gelenkerkrankungen |
| US6669623B1 (en) | 1999-08-19 | 2003-12-30 | Magforce Applications Gmbh | Medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases |
| DE19940220B4 (de) * | 1999-08-19 | 2007-05-03 | Magforce Nanotechnologies Ag | Medizinisches Präparat zur Behandlung von Arthrose, Arthritis und anderen rheumatischen Gelenkerkrankungen |
| US7407704B2 (en) | 1999-10-27 | 2008-08-05 | Henkel Kgaa | Process for adhesive separation of bonded joints |
| DE10020376A1 (de) * | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
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| WO2002018499A1 (de) | 2000-09-01 | 2002-03-07 | Henkel Kommanditgesellschaft Auk Aktien | Reaktionsklebstoff mit mindestens einer mikroverkapselten komponente |
| US7651580B2 (en) | 2001-12-21 | 2010-01-26 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Nanoparticulate preparation |
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| DE10205332A1 (de) * | 2002-02-06 | 2003-08-28 | Berlin Heart Ag | Verfahren zur Herstellung von magnetischen Nanoteilchen |
| DE10205332B4 (de) * | 2002-02-06 | 2004-02-12 | Berlin Heart Ag | Verfahren zur Herstellung von magnetischen Nanoteilchen |
| WO2007019845A3 (de) * | 2005-08-19 | 2007-04-19 | Magforce Nanotechnologies Ag | Verfahren zur einschleusung von therapeutischen substanzen in zellen |
| EP2266544A2 (de) | 2005-08-19 | 2010-12-29 | MagForce Nanotechnologies AG | Verfahren zur Einschleusung von therapeutischen Substanzen in Zellen |
| EP2266544A3 (de) * | 2005-08-19 | 2012-08-08 | MagForce Nanotechnologies AG | Verfahren zur Einschleusung von therapeutischen Substanzen in Zellen |
| US9827312B2 (en) | 2005-08-19 | 2017-11-28 | Magforce Ag | Method for carrying therapeutic substances into cells |
| DE102005039579B4 (de) | 2005-08-19 | 2022-06-30 | Magforce Ag | Verfahren zur Einschleusung von therapeutischen Substanzen in Zellen |
| EP2269664A2 (de) | 2007-01-21 | 2011-01-05 | Hemoteq AG | Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse |
| WO2013021039A1 (en) | 2011-08-11 | 2013-02-14 | Basf Se | Microwave absorbing composition |
| DE102016006320A1 (de) | 2016-05-25 | 2017-11-30 | Carl Freudenberg Kg | Fixierbare Flächengebilde |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1260724A (zh) | 2000-07-19 |
| US6979466B2 (en) | 2005-12-27 |
| JP4902900B2 (ja) | 2012-03-21 |
| US20030180370A1 (en) | 2003-09-25 |
| US6541039B1 (en) | 2003-04-01 |
| EP1001811B1 (de) | 2002-09-11 |
| DK1001811T3 (da) | 2003-01-20 |
| ES2181256T3 (es) | 2003-02-16 |
| EP1001811A1 (de) | 2000-05-24 |
| CN1211127C (zh) | 2005-07-20 |
| JP2010001308A (ja) | 2010-01-07 |
| DE59805535D1 (de) | 2002-10-17 |
| WO1998058673A1 (de) | 1998-12-30 |
| ATE223731T1 (de) | 2002-09-15 |
| PT1001811E (pt) | 2003-01-31 |
| JP5116743B2 (ja) | 2013-01-09 |
| JP2002507964A (ja) | 2002-03-12 |
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