DE19705963A1 - Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung - Google Patents

Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung

Info

Publication number
DE19705963A1
DE19705963A1 DE19705963A DE19705963A DE19705963A1 DE 19705963 A1 DE19705963 A1 DE 19705963A1 DE 19705963 A DE19705963 A DE 19705963A DE 19705963 A DE19705963 A DE 19705963A DE 19705963 A1 DE19705963 A1 DE 19705963A1
Authority
DE
Germany
Prior art keywords
independently
compounds
nhr
mixture
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19705963A
Other languages
German (de)
English (en)
Inventor
Heinke Von Dr Seggern
Axel Dr Hoffmann
Eugen Dr Falk
Brigitte Dr Hoersch
Adolf Heinz Dr Linkies
Heiner Dr Glombik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19705963A priority Critical patent/DE19705963A1/de
Priority to TR1999/01978T priority patent/TR199901978T2/xx
Priority to PL98335106A priority patent/PL335106A1/xx
Priority to AU64983/98A priority patent/AU728985B2/en
Priority to BR9807408-3A priority patent/BR9807408A/pt
Priority to CA002281602A priority patent/CA2281602A1/en
Priority to HU0001012A priority patent/HUP0001012A3/hu
Priority to CZ992932A priority patent/CZ293299A3/cs
Priority to JP53537598A priority patent/JP2002515930A/ja
Priority to EP98910693A priority patent/EP0960141A1/de
Priority to RU99119911/04A priority patent/RU99119911A/ru
Priority to CN98803685A priority patent/CN1251112A/zh
Priority to PCT/EP1998/000898 priority patent/WO1998036002A1/de
Priority to KR1019997007457A priority patent/KR20000071167A/ko
Publication of DE19705963A1 publication Critical patent/DE19705963A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/10—Esters
    • C08F20/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C08F20/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/10—Esters
    • C08F22/1006—Esters of polyhydric alcohols or polyhydric phenols, e.g. ethylene glycol dimethacrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/36—Amides or imides
    • C08F22/38—Amides
    • C08F22/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19705963A 1997-02-17 1997-02-17 Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung Withdrawn DE19705963A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE19705963A DE19705963A1 (de) 1997-02-17 1997-02-17 Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung
TR1999/01978T TR199901978T2 (xx) 1997-02-17 1998-02-17 Safra asidini emme etkili �apraz ba�lant�l� vinil polimerleri.
PL98335106A PL335106A1 (en) 1997-02-17 1998-02-17 Crosslinked vinyl polymers exhibiting bile acids absorbing properties
AU64983/98A AU728985B2 (en) 1997-02-17 1998-02-17 Crosslinked vinyl polymers having bile acid adsorber action
BR9807408-3A BR9807408A (pt) 1997-02-17 1998-02-17 Polìmeros de vinila reticulados tendo ação de absorvente do ácido biliar
CA002281602A CA2281602A1 (en) 1997-02-17 1998-02-17 Cross-linked vinyl polymers with bile acid adsorbing effect
HU0001012A HUP0001012A3 (en) 1997-02-17 1998-02-17 Cross-linked vinyl polymers with bile acid adsorbing effect
CZ992932A CZ293299A3 (cs) 1997-02-17 1998-02-17 Zesítěné vinylpolymery s adsorpčním účinkem na kyseliny žlučové, jejich monomery, způsob jejich výroby, léčiva tyto látky obsahující a jejich použití
JP53537598A JP2002515930A (ja) 1997-02-17 1998-02-17 胆汁酸吸着作用を有する架橋結合性ビニルポリマー
EP98910693A EP0960141A1 (de) 1997-02-17 1998-02-17 Vernetzte vinylpolymere mit gallensäure-adsorberwirkung
RU99119911/04A RU99119911A (ru) 1997-02-17 1998-02-17 Сшитые виниловые полимеры, способные адсорбировать желчные кислоты, исходные соединения, способы их получения, смеси полимеров и лекарственное средство
CN98803685A CN1251112A (zh) 1997-02-17 1998-02-17 具有胆汁酸吸收作用的交联乙烯基聚合物
PCT/EP1998/000898 WO1998036002A1 (de) 1997-02-17 1998-02-17 Vernetzte vinylpolymere mit gallensäure-adsorberwirkung
KR1019997007457A KR20000071167A (ko) 1997-02-17 1998-02-17 담즙산 흡착 효과를 갖는 가교결합된 비닐 중합체

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19705963A DE19705963A1 (de) 1997-02-17 1997-02-17 Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung

Publications (1)

Publication Number Publication Date
DE19705963A1 true DE19705963A1 (de) 1998-08-20

Family

ID=7820445

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19705963A Withdrawn DE19705963A1 (de) 1997-02-17 1997-02-17 Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung

Country Status (14)

Country Link
EP (1) EP0960141A1 (cs)
JP (1) JP2002515930A (cs)
KR (1) KR20000071167A (cs)
CN (1) CN1251112A (cs)
AU (1) AU728985B2 (cs)
BR (1) BR9807408A (cs)
CA (1) CA2281602A1 (cs)
CZ (1) CZ293299A3 (cs)
DE (1) DE19705963A1 (cs)
HU (1) HUP0001012A3 (cs)
PL (1) PL335106A1 (cs)
RU (1) RU99119911A (cs)
TR (1) TR199901978T2 (cs)
WO (1) WO1998036002A1 (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000526A1 (de) * 1998-06-30 2000-01-06 Linkies, Adolf, Heinz Neues verfahren zur herstellung vernetzter vinylpolymere auf der basis quartärer ammoniumgruppen mit gallensäure-adsorberwirkung
EP1505092A3 (en) * 2003-08-07 2005-03-02 Mitsubishi Gas Chemical Company, Inc. Gas barrier (meth)acrylate resin cured product

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DK1181323T3 (da) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
US7291673B2 (en) 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US8282912B2 (en) 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
WO2008125655A1 (en) 2007-04-13 2008-10-23 Kuros Biosurgery Ag Polymeric tissue sealant
JP6126498B2 (ja) * 2013-02-15 2017-05-10 富士フイルム株式会社 高分子機能性膜及びその製造方法
JP6071957B2 (ja) * 2014-03-07 2017-02-01 富士フイルム株式会社 イオン交換性ポリマーおよびその製造方法、電解質膜およびその製造方法ならびにイオン交換性ポリマー製造用組成物
WO2017038328A1 (ja) * 2015-08-31 2017-03-09 富士フイルム株式会社 イオン交換ポリマー、硬化性組成物、硬化物、部材、及び、装置
WO2019054797A1 (ko) 2017-09-15 2019-03-21 주식회사 엘지화학 중합성 조성물, 고분자 캡슐 및 이를 포함하는 섬유 유연제 조성물
CN110317588A (zh) * 2018-03-29 2019-10-11 中国石油化工股份有限公司 一种阳离子表面活性剂及其制备方法和起泡剂及其应用
IT201900020949A1 (it) * 2019-11-12 2021-05-12 Univ Degli Studi Di Trieste Monomero fotopolimerizzabile antibatterico

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206115A1 (es) * 1973-06-11 1976-06-30 Merck & Co Inc Procedimiento para preparar un polimero lineal no ramificado y no reticulado
GB9123683D0 (en) * 1991-11-07 1992-01-02 Sandoz Ltd Improvements in or relating to organic compounds
DE69307112T2 (de) * 1992-07-06 1997-04-17 Otsuka Kagaku Kk Polymerisierbares monomer, polymere und verfahren zu seiner herstellung
DE59307535D1 (de) * 1992-07-22 1997-11-20 Hoechst Ag Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000526A1 (de) * 1998-06-30 2000-01-06 Linkies, Adolf, Heinz Neues verfahren zur herstellung vernetzter vinylpolymere auf der basis quartärer ammoniumgruppen mit gallensäure-adsorberwirkung
EP1505092A3 (en) * 2003-08-07 2005-03-02 Mitsubishi Gas Chemical Company, Inc. Gas barrier (meth)acrylate resin cured product
US7087695B2 (en) 2003-08-07 2006-08-08 Mitsubishi Gas Chemical Company, Inc. Gas barrier(meth)acrylate resin cured product

Also Published As

Publication number Publication date
BR9807408A (pt) 2000-03-14
AU6498398A (en) 1998-09-08
PL335106A1 (en) 2000-04-10
CZ293299A3 (cs) 1999-12-15
AU728985B2 (en) 2001-01-25
EP0960141A1 (de) 1999-12-01
JP2002515930A (ja) 2002-05-28
CA2281602A1 (en) 1998-08-20
HUP0001012A3 (en) 2001-11-28
CN1251112A (zh) 2000-04-19
TR199901978T2 (xx) 2000-06-21
HUP0001012A2 (hu) 2000-09-28
RU99119911A (ru) 2001-06-27
KR20000071167A (ko) 2000-11-25
WO1998036002A1 (de) 1998-08-20

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