DE19610357C2 - Geminale Difluorderivate von Phenylacetamid und Phenylessigsäure, Verfahren zu deren Herstellung sowie deren pharmazeutische Zusammensetzungen - Google Patents

Geminale Difluorderivate von Phenylacetamid und Phenylessigsäure, Verfahren zu deren Herstellung sowie deren pharmazeutische Zusammensetzungen

Info

Publication number
DE19610357C2
DE19610357C2 DE19610357A DE19610357A DE19610357C2 DE 19610357 C2 DE19610357 C2 DE 19610357C2 DE 19610357 A DE19610357 A DE 19610357A DE 19610357 A DE19610357 A DE 19610357A DE 19610357 C2 DE19610357 C2 DE 19610357C2
Authority
DE
Germany
Prior art keywords
group
difluoro
hydrogen
substituted
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19610357A
Other languages
German (de)
English (en)
Other versions
DE19610357A1 (de
Inventor
Nubia Boechat
Angelo Da Cunha Pinto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacao Oswaldo Cruz
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Publication of DE19610357A1 publication Critical patent/DE19610357A1/de
Application granted granted Critical
Publication of DE19610357C2 publication Critical patent/DE19610357C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19610357A 1996-03-11 1996-03-15 Geminale Difluorderivate von Phenylacetamid und Phenylessigsäure, Verfahren zu deren Herstellung sowie deren pharmazeutische Zusammensetzungen Expired - Fee Related DE19610357C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR9600975A BR9600975A (pt) 1996-03-11 1996-03-11 Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas

Publications (2)

Publication Number Publication Date
DE19610357A1 DE19610357A1 (de) 1997-09-18
DE19610357C2 true DE19610357C2 (de) 1998-08-13

Family

ID=38353109

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19610357A Expired - Fee Related DE19610357C2 (de) 1996-03-11 1996-03-15 Geminale Difluorderivate von Phenylacetamid und Phenylessigsäure, Verfahren zu deren Herstellung sowie deren pharmazeutische Zusammensetzungen

Country Status (10)

Country Link
JP (1) JP3947242B2 (https=)
CN (1) CN1101806C (https=)
BE (1) BE1010031A5 (https=)
BR (1) BR9600975A (https=)
CH (1) CH690722A5 (https=)
DE (1) DE19610357C2 (https=)
ES (1) ES2130923B1 (https=)
FR (1) FR2745810B1 (https=)
GB (1) GB2311066B (https=)
IT (1) IT1283256B1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) * 1999-09-27 1999-11-24 Novartis Ag Processes
JP5685384B2 (ja) * 2010-03-29 2015-03-18 公益財団法人相模中央化学研究所 ３，３−ジフルオロ−２，３−ジヒドロインドール−２−オン誘導体の製造方法
CN108299137B (zh) * 2018-04-09 2020-04-14 中南大学 一种靛红腙类化合物选择性氟化方法
GB201916600D0 (en) * 2019-11-14 2020-01-01 Syngenta Crop Protection Ag 81991-gb-reg-org-nat-1
CN113698308B (zh) * 2021-08-25 2024-06-21 山东辰龙药业有限公司 一种溴芬酸钠合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Kornilov, Andrew M. [u.a.]: Selective Incorpora- tion of CF¶2¶-Group into the Natural Compounds Molecules. Synthesis of 14,14-Difluorocoriolic Acid. In: Tetrahedron: Asymmetry, 1995, Vol.3, No.1, S.199-206 *
Middleton, W.J., Bingham, E.M.: alpha,alpha-Difluoroaryl- acetic Acids: Preparation from (Diethylamino) sul-fur Trifluoride and 2-Oxoarylacetates. In: J. Org. Chem., 1980, S.2883-2887 *
Welch, John T. u.a.: Fluorine in Bioorganic Che- mistry, New York [u.a.]: John Wiley & Sons, 1991, S.11-12 u. 22-25 *

Also Published As

Publication number Publication date
FR2745810A1 (fr) 1997-09-12
ES2130923B1 (es) 2000-01-16
FR2745810B1 (fr) 1998-06-19
CN1159443A (zh) 1997-09-17
JPH09323962A (ja) 1997-12-16
CH690722A5 (fr) 2000-12-29
CN1101806C (zh) 2003-02-19
BE1010031A5 (fr) 1997-11-04
GB2311066B (en) 1999-12-08
ITMI960505A1 (it) 1997-09-15
JP3947242B2 (ja) 2007-07-18
ES2130923A1 (es) 1999-07-01
GB9605407D0 (en) 1996-05-15
DE19610357A1 (de) 1997-09-18
IT1283256B1 (it) 1998-04-16
ITMI960505A0 (https=) 1996-03-15
BR9600975A (pt) 1997-12-30
GB2311066A (en) 1997-09-17

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Legal Events

Date Code Title Description
ON Later submitted papers
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: FUNDACAO OSWALDO CRUZ (FIOCRUZ), RIO DE JANEIRO, B

8339 Ceased/non-payment of the annual fee