ES2130923A1 - Nuevos derivados gem-difluoro de la fenilacetamida y del acido fenilacetico y sus usos farmaceuticos. - Google Patents

Nuevos derivados gem-difluoro de la fenilacetamida y del acido fenilacetico y sus usos farmaceuticos.

Info

Publication number
ES2130923A1
ES2130923A1 ES09600651A ES9600651A ES2130923A1 ES 2130923 A1 ES2130923 A1 ES 2130923A1 ES 09600651 A ES09600651 A ES 09600651A ES 9600651 A ES9600651 A ES 9600651A ES 2130923 A1 ES2130923 A1 ES 2130923A1
Authority
ES
Spain
Prior art keywords
substituted
lower alkyl
hydrogen
group
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600651A
Other languages
English (en)
Other versions
ES2130923B1 (es
Inventor
Nubia Boechat
Cunha Pinto Angelo Da
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacao Oswaldo Cruz
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Publication of ES2130923A1 publication Critical patent/ES2130923A1/es
Application granted granted Critical
Publication of ES2130923B1 publication Critical patent/ES2130923B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nuevos derivados gem-diflúor de la fenilacetamida y del ácido fenilacético y sus usos farmacéuticos. Los derivados gem-diflúor de la fenilacetamida y del ácido fenilacético tienen la fórmula (IV) en la que R{sup,1 es hidrógeno o acilo opcionalmente sustituido; R{sup,2 es hidrógeno, alquilo opcionalmente sustituido, nitro, halógeno, metilendioxi, trifluorometilo u OR"''; Y es oxígeno, azufre o NR"''"''; R{sub,3 es hidrógeno, alquilo opcionalmente sustituido, fenilo, arilo sustituido o un metal (sodio, potasio, calcio, magnesio, zinc o aluminio); R"''y R"''"'' son hidrógeno, alquilo opcionalmente sustituido, fenilo o arilo sustituido. Los compuestos (IV) pueden obtenerse por reacción de isatinas con trifluoruro de azufre dietilamino y posterior reacción del producto obtenido con un reactivo nucleófilo apropiado. Estos compuestos (IV) son útiles para el tratamiento de todos los trastornos dolorosos asociados con enfermedades inflamatorias y/o reumáticas.
ES009600651A 1996-03-11 1996-03-15 Nuevos derivados gem-difluoro de la fenilacetamida y del acido fenilacetico y sus usos farmaceuticos. Expired - Fee Related ES2130923B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR9600975A BR9600975A (pt) 1996-03-11 1996-03-11 Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas

Publications (2)

Publication Number Publication Date
ES2130923A1 true ES2130923A1 (es) 1999-07-01
ES2130923B1 ES2130923B1 (es) 2000-01-16

Family

ID=38353109

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009600651A Expired - Fee Related ES2130923B1 (es) 1996-03-11 1996-03-15 Nuevos derivados gem-difluoro de la fenilacetamida y del acido fenilacetico y sus usos farmaceuticos.

Country Status (10)

Country Link
JP (1) JP3947242B2 (es)
CN (1) CN1101806C (es)
BE (1) BE1010031A5 (es)
BR (1) BR9600975A (es)
CH (1) CH690722A5 (es)
DE (1) DE19610357C2 (es)
ES (1) ES2130923B1 (es)
FR (1) FR2745810B1 (es)
GB (1) GB2311066B (es)
IT (1) IT1283256B1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) 1999-09-27 1999-11-24 Novartis Ag Processes
JP5685384B2 (ja) * 2010-03-29 2015-03-18 公益財団法人相模中央化学研究所 ３，３−ジフルオロ−２，３−ジヒドロインドール−２−オン誘導体の製造方法
CN108299137B (zh) * 2018-04-09 2020-04-14 中南大学 一种靛红腙类化合物选择性氟化方法
CN113698308A (zh) * 2021-08-25 2021-11-26 山东辰龙药业有限公司 一种溴芬酸钠新合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
FR2499981A1 (fr) * 1981-02-17 1982-08-20 Robins Co Inc A H Acides amino-2 halogenobenzoyl-3 methylphenylacetiques et leurs esters et sels utiles comme medicaments anti-inflammatoires et analgesiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
FR2499981A1 (fr) * 1981-02-17 1982-08-20 Robins Co Inc A H Acides amino-2 halogenobenzoyl-3 methylphenylacetiques et leurs esters et sels utiles comme medicaments anti-inflammatoires et analgesiques

Also Published As

Publication number Publication date
GB2311066B (en) 1999-12-08
ITMI960505A0 (es) 1996-03-15
ES2130923B1 (es) 2000-01-16
BR9600975A (pt) 1997-12-30
BE1010031A5 (fr) 1997-11-04
FR2745810B1 (fr) 1998-06-19
FR2745810A1 (fr) 1997-09-12
GB9605407D0 (en) 1996-05-15
CH690722A5 (fr) 2000-12-29
DE19610357A1 (de) 1997-09-18
DE19610357C2 (de) 1998-08-13
GB2311066A (en) 1997-09-17
JP3947242B2 (ja) 2007-07-18
ITMI960505A1 (it) 1997-09-15
CN1159443A (zh) 1997-09-17
JPH09323962A (ja) 1997-12-16
IT1283256B1 (it) 1998-04-16
CN1101806C (zh) 2003-02-19

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