DE19609476A1 - Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen - Google Patents
Stabile zur parenteralen Verabreichung geeignete Carotinoid-EmulsionenInfo
- Publication number
- DE19609476A1 DE19609476A1 DE19609476A DE19609476A DE19609476A1 DE 19609476 A1 DE19609476 A1 DE 19609476A1 DE 19609476 A DE19609476 A DE 19609476A DE 19609476 A DE19609476 A DE 19609476A DE 19609476 A1 DE19609476 A1 DE 19609476A1
- Authority
- DE
- Germany
- Prior art keywords
- oil
- carotenoid
- water
- phase
- carotene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 230000009286 beneficial effect Effects 0.000 description 1
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- RAFGELQLHMBRHD-SLEZCNMESA-N bixin Chemical compound COC(=O)\C=C\C(\C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O RAFGELQLHMBRHD-SLEZCNMESA-N 0.000 description 1
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- 239000001659 canthaxanthin Substances 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- PANKHBYNKQNAHN-JUMCEFIXSA-N carotenoid dicarboxylic acid Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)O)C=CC=C(/C)C(=O)O PANKHBYNKQNAHN-JUMCEFIXSA-N 0.000 description 1
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- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000019247 citranaxanthin Nutrition 0.000 description 1
- PRDJTOVRIHGKNU-ZWERVMMHSA-N citranaxanthin Chemical compound CC(=O)\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C PRDJTOVRIHGKNU-ZWERVMMHSA-N 0.000 description 1
- PRDJTOVRIHGKNU-UHFFFAOYSA-N citranaxanthine Natural products CC(=O)C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C PRDJTOVRIHGKNU-UHFFFAOYSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- PANKHBYNKQNAHN-MQQNZMFNSA-N crocetin Chemical compound OC(=O)C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C(O)=O PANKHBYNKQNAHN-MQQNZMFNSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
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- 235000006694 eating habits Nutrition 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
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- 150000002430 hydrocarbons Chemical class 0.000 description 1
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- 238000001802 infusion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 229940057917 medium chain triglycerides Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
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- 235000010755 mineral Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
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- 229940126701 oral medication Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
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- 235000012045 salad Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
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- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19609476A DE19609476A1 (de) | 1996-03-11 | 1996-03-11 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
| EP97103483A EP0800824B1 (de) | 1996-03-11 | 1997-03-04 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
| DE59704347T DE59704347D1 (de) | 1996-03-11 | 1997-03-04 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
| AT97103483T ATE204472T1 (de) | 1996-03-11 | 1997-03-04 | Stabile zur parenteralen verabreichung geeignete carotinoid-emulsionen |
| ES97103483T ES2163055T3 (es) | 1996-03-11 | 1997-03-04 | Emulsiones de carotenoides estables apropiadas para la administracion parenteral. |
| CA002199414A CA2199414A1 (en) | 1996-03-11 | 1997-03-06 | Stable carotenoid emulsions suitable for parenteral administration |
| AU16203/97A AU1620397A (en) | 1996-03-11 | 1997-03-07 | Stable carotenoid emulsions suitable for parenteral administration |
| US08/813,977 US5925684A (en) | 1996-03-11 | 1997-03-10 | Stable carotenoid emulsions suitable for parenteral administration |
| JP9054400A JPH09328419A (ja) | 1996-03-11 | 1997-03-10 | 安定な水中油形エマルジョン及びその製造方法 |
| CN97109609A CN1074917C (zh) | 1996-03-11 | 1997-03-11 | 适合于非肠道给药的稳定的类胡萝卜素乳剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19609476A DE19609476A1 (de) | 1996-03-11 | 1996-03-11 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19609476A1 true DE19609476A1 (de) | 1997-09-18 |
Family
ID=7787923
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19609476A Withdrawn DE19609476A1 (de) | 1996-03-11 | 1996-03-11 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
| DE59704347T Expired - Fee Related DE59704347D1 (de) | 1996-03-11 | 1997-03-04 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59704347T Expired - Fee Related DE59704347D1 (de) | 1996-03-11 | 1997-03-04 | Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5925684A (OSRAM) |
| EP (1) | EP0800824B1 (OSRAM) |
| JP (1) | JPH09328419A (OSRAM) |
| CN (1) | CN1074917C (OSRAM) |
| AT (1) | ATE204472T1 (OSRAM) |
| AU (1) | AU1620397A (OSRAM) |
| CA (1) | CA2199414A1 (OSRAM) |
| DE (2) | DE19609476A1 (OSRAM) |
| ES (1) | ES2163055T3 (OSRAM) |
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| DE10221212A1 (de) * | 2002-05-13 | 2003-11-27 | Andreas Maack | Sporopollenin enthaltende lösliche Zusammensetzung und Verwendung |
| WO2008113421A1 (de) * | 2007-03-19 | 2008-09-25 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Neue pharmazeutische zusammensetzungen für die lipolyse und verfahren zu deren herstellung |
| WO2016188876A1 (en) * | 2015-05-22 | 2016-12-01 | Fresenius Kabi Deutschland Gmbh | Vitamin a for parenteral administration |
| WO2016188874A1 (en) * | 2015-05-22 | 2016-12-01 | Fresenius Kabi Deutschland Gmbh | Vitamin a for parenteral administration |
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| DE19653410A1 (de) * | 1996-12-20 | 1998-06-25 | Basf Ag | Verwendung von Carotinoid-Solubilisaten zum Färben von Lebensmitteln und pharmazeutischen Zubereitungen |
| AT408186B (de) * | 1998-12-15 | 2001-09-25 | Sanochemia Pharmazeutika Ag | Wässerige zubereitung von beta-carotin |
| GB2350297A (en) * | 1999-05-27 | 2000-11-29 | Abbott Lab | Injectable halogenated anesthetic formulation in emulsion form |
| AU7638300A (en) * | 1999-10-20 | 2001-04-30 | Vesifact Ag | Microemulsion preconcentrates and microemulsions |
| DE19951615A1 (de) * | 1999-10-26 | 2001-05-03 | Basf Ag | Verfahren zur Stabilisierung von flüssigen, wäßrigen Präparaten fettlöslicher Substanzen |
| US6455072B1 (en) * | 1999-10-28 | 2002-09-24 | Ingredient Innovations International | Stable aqueous dispersion of nutrients |
| EP1227780A4 (en) * | 1999-10-28 | 2006-09-06 | Ingredient Innovations Interna | STABLE AQUEOUS DISPERSION OF NUTRIENT ELEMENTS |
| US6617305B1 (en) * | 2000-10-10 | 2003-09-09 | Ingredient Innovations Internaitonal | Stable aqueous dispersion of nutrients |
| US20070179197A1 (en) * | 2000-05-01 | 2007-08-02 | Accera, Inc. | Compositions and methods for improving or preserving brain function |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
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| US6623765B1 (en) | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
| EP1227082B1 (en) * | 2001-01-24 | 2004-06-16 | Kuraray Co., Ltd. | Process for producing carotenoid emulsion |
| US6635293B2 (en) * | 2001-10-23 | 2003-10-21 | Kemin Foods, L.C. | Finely dispersed carotenoid suspensions for use in foods and a process for their preparation |
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| CA2933086C (en) * | 2013-12-11 | 2019-04-02 | Health-Ever Biotech Co. Ltd | Pharmaceutical compositions of carotenoid |
| CN106617050A (zh) * | 2016-11-08 | 2017-05-10 | 云南爱尔康生物技术有限公司 | 一种岩藻黄素纳米乳液及其制备方法 |
| CN107271378B (zh) * | 2017-04-13 | 2019-12-20 | 云南民族大学 | 虾青素抗脂质过氧化活性的测定方法 |
| US20200383933A1 (en) * | 2017-09-05 | 2020-12-10 | Universidad De Chile | Method for obtaining nanostructures with carotenoids and nanostructures obtained |
| CN111165824A (zh) * | 2020-01-21 | 2020-05-19 | 北京金康普食品科技有限公司 | 护眼微量营养素预混料乳剂及其制备方法和应用 |
| CN111296730A (zh) * | 2020-03-06 | 2020-06-19 | 广州市食品工业研究所有限公司 | 一种稳定性好的叶黄素纳米乳液及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH420822A (de) * | 1960-10-17 | 1966-09-15 | Hoffmann La Roche | Wasserdispergierbare Carotinoidzubereitung |
| DE2236899A1 (de) * | 1972-07-27 | 1974-02-07 | Philips Patentverwaltung | Mit wasser mischbare carotinoidemulsion |
| DE2254105A1 (de) * | 1972-11-04 | 1974-05-16 | Philips Patentverwaltung | Verfahren zur herstellung von carotinoid-emulsionen |
| US4107343A (en) * | 1976-11-08 | 1978-08-15 | Scm Corporation | Whippable emulsion stable at room temperature |
| DE3048000A1 (de) * | 1980-12-19 | 1982-07-15 | Basf Ag | Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung |
| JPS5910511A (ja) * | 1982-07-07 | 1984-01-20 | Eisai Co Ltd | 脂溶性物質含有水性液 |
| DE3702030A1 (de) * | 1987-01-24 | 1988-08-04 | Basf Ag | Pulverfoermige, wasserdispergierbare carotinoid-zubereitungen und verfahren zu ihrer herstellung |
| FR2630346B1 (fr) * | 1988-04-22 | 1991-03-22 | Dubois Jacques | Produits nouveaux comportant une emulsion d'eau et d'hydrocarbures paraffiniques huileux additionnes d'extraits de lecithine et procedes de fabrication |
| DE4031094A1 (de) * | 1990-10-02 | 1992-04-09 | Basf Ag | Verfahren zur herstellung von stabilen injizierbaren (beta)-carotin-solubilisaten |
| DE4200728A1 (de) * | 1992-01-14 | 1993-07-15 | Basf Ag | Stabile, fluessige praeparate fettloeslicher substanzen |
| IL101007A (en) * | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
| PT689426E (pt) * | 1993-03-22 | 2000-11-30 | Cognis Australia Pty Ltd | Agente terapeutico para o tratamento de melanomas |
| ATE218855T1 (de) * | 1993-03-22 | 2002-06-15 | Cognis Australia Pty Ltd | Wasserdispersible therapeutische carotenoid verbindungen |
| DE4405545A1 (de) * | 1994-02-22 | 1995-08-31 | Dietl Hans | Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation |
-
1996
- 1996-03-11 DE DE19609476A patent/DE19609476A1/de not_active Withdrawn
-
1997
- 1997-03-04 DE DE59704347T patent/DE59704347D1/de not_active Expired - Fee Related
- 1997-03-04 AT AT97103483T patent/ATE204472T1/de not_active IP Right Cessation
- 1997-03-04 ES ES97103483T patent/ES2163055T3/es not_active Expired - Lifetime
- 1997-03-04 EP EP97103483A patent/EP0800824B1/de not_active Expired - Lifetime
- 1997-03-06 CA CA002199414A patent/CA2199414A1/en not_active Abandoned
- 1997-03-07 AU AU16203/97A patent/AU1620397A/en not_active Abandoned
- 1997-03-10 JP JP9054400A patent/JPH09328419A/ja active Pending
- 1997-03-10 US US08/813,977 patent/US5925684A/en not_active Expired - Fee Related
- 1997-03-11 CN CN97109609A patent/CN1074917C/zh not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10221212A1 (de) * | 2002-05-13 | 2003-11-27 | Andreas Maack | Sporopollenin enthaltende lösliche Zusammensetzung und Verwendung |
| US7182965B2 (en) | 2002-05-13 | 2007-02-27 | Andreas Maack | Soluble composition containing sporopollenin and the use thereof |
| WO2008113421A1 (de) * | 2007-03-19 | 2008-09-25 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Neue pharmazeutische zusammensetzungen für die lipolyse und verfahren zu deren herstellung |
| WO2016188876A1 (en) * | 2015-05-22 | 2016-12-01 | Fresenius Kabi Deutschland Gmbh | Vitamin a for parenteral administration |
| WO2016188874A1 (en) * | 2015-05-22 | 2016-12-01 | Fresenius Kabi Deutschland Gmbh | Vitamin a for parenteral administration |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1164387A (zh) | 1997-11-12 |
| EP0800824A1 (de) | 1997-10-15 |
| DE59704347D1 (de) | 2001-09-27 |
| JPH09328419A (ja) | 1997-12-22 |
| CA2199414A1 (en) | 1997-09-11 |
| ES2163055T3 (es) | 2002-01-16 |
| EP0800824B1 (de) | 2001-08-22 |
| AU1620397A (en) | 1997-09-18 |
| ATE204472T1 (de) | 2001-09-15 |
| US5925684A (en) | 1999-07-20 |
| CN1074917C (zh) | 2001-11-21 |
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