DE19575031I2 - Monoaminakridinen bei Mangelerscheinungen des cholinergen Nervensystems - Google Patents
Monoaminakridinen bei Mangelerscheinungen des cholinergen NervensystemsInfo
- Publication number
- DE19575031I2 DE19575031I2 DE1995175031 DE19575031C DE19575031I2 DE 19575031 I2 DE19575031 I2 DE 19575031I2 DE 1995175031 DE1995175031 DE 1995175031 DE 19575031 C DE19575031 C DE 19575031C DE 19575031 I2 DE19575031 I2 DE 19575031I2
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- double bond
- substituent
- ethoxy
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91407686A | 1986-10-01 | 1986-10-01 | |
US07/098,871 US4816456A (en) | 1986-10-01 | 1987-09-24 | Administration of monoamine acridines in cholinergic neuronal deficit states |
PCT/US1987/002422 WO1988002256A1 (en) | 1986-10-01 | 1987-09-28 | The administration of monoamine acridines in cholinergic neuronal deficit states |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19575031I2 true DE19575031I2 (de) | 2003-05-22 |
Family
ID=26795215
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3789967T Expired - Lifetime DE3789967T2 (de) | 1986-10-01 | 1987-09-28 | Anwendung von monoaminakridinen bei mangelerscheinungen des cholinergen nervensystems. |
DE1995175031 Active DE19575031I2 (de) | 1986-10-01 | 1987-09-28 | Monoaminakridinen bei Mangelerscheinungen des cholinergen Nervensystems |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3789967T Expired - Lifetime DE3789967T2 (de) | 1986-10-01 | 1987-09-28 | Anwendung von monoaminakridinen bei mangelerscheinungen des cholinergen nervensystems. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4816456A (de) |
EP (2) | EP0328535B1 (de) |
JP (1) | JPH0655725B2 (de) |
AT (1) | ATE106245T1 (de) |
AU (2) | AU621035B2 (de) |
CA (1) | CA1335813C (de) |
DE (2) | DE3789967T2 (de) |
DK (1) | DK295888A (de) |
FI (1) | FI891548A0 (de) |
HK (1) | HK1001669A1 (de) |
LU (1) | LU88749I2 (de) |
MX (1) | MX9203762A (de) |
WO (1) | WO1988002256A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
US4897400A (en) * | 1987-02-13 | 1990-01-30 | Hoeschst-Roussel Pharmaceuticals, Inc. | 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds useful for incresing the cholinergic function in a mammal |
NZ223875A (en) * | 1987-03-17 | 1991-01-29 | Hoechst Roussel Pharma | 9-aminotetrahydroacridines and related homologues and pharmaceutical compositions |
US6075144A (en) | 1987-04-20 | 2000-06-13 | Hoechst Marion Roussel, Inc. | 9-hydroxyamino tetrahydroacridine and related compounds |
US5013741A (en) * | 1987-09-08 | 1991-05-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal |
US5037833A (en) * | 1988-07-25 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals Inc. | N-[substituted alkylidene]fused-bicycloalkylidene quinolinamines useful for enhancing the cholinergic function in a mammal |
US5008853A (en) | 1987-12-02 | 1991-04-16 | Xerox Corporation | Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment |
DE3889302T2 (de) | 1987-12-03 | 1994-10-20 | Mitsubishi Chem Ind | 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff. |
IE62871B1 (en) * | 1988-03-08 | 1995-03-08 | Warner Lambert Co | Compositions with enhanced penetration |
US5019395A (en) * | 1988-03-08 | 1991-05-28 | Warner-Lambert Company | Compositions with enhanced penetration |
JPH02180871A (ja) * | 1988-11-16 | 1990-07-13 | Hoechst Roussel Pharmaceut Inc | ヒドロキシ―1,2,3,4―テトラヒドロアミノアクリジンおよびその製造法 |
FR2651230B1 (fr) * | 1989-08-25 | 1992-03-13 | Synthese Rech | Derives de la 5-amino-1,2,3,4 tetrahydro-acridine et applications comme medicaments. |
US5112829A (en) * | 1989-11-28 | 1992-05-12 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
US4994452A (en) * | 1989-11-28 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
US5508280A (en) * | 1990-05-18 | 1996-04-16 | Merrell Pharmaceuticals, Inc. | 5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists |
US5610155A (en) * | 1992-04-09 | 1997-03-11 | Dr. Karl Thomae Gmbh | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation |
US5422350A (en) * | 1992-09-10 | 1995-06-06 | Warner-Lambert Company | Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use |
US5466696A (en) * | 1992-09-10 | 1995-11-14 | Warner Lambert Company | Tacrine and cytochrome P450 oxidase inhibitors and methods of use |
US5434170A (en) * | 1993-12-23 | 1995-07-18 | Andrulis Pharmaceuticals Corp. | Method for treating neurocognitive disorders |
US5698224A (en) * | 1994-06-27 | 1997-12-16 | Alza Corporation | Tacrine therapy |
DE19533089C1 (de) * | 1995-09-07 | 1997-05-22 | Hexal Ag | Tacrin-Pflaster |
US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
GB9524346D0 (en) * | 1995-11-29 | 1996-01-31 | Univ Strathclyde | Polycyclic compounds |
US5783584A (en) * | 1995-12-11 | 1998-07-21 | Mayo Foundation For Medical Education And Research | THA analogs useful as cholinesterase inhibitors |
US5929093A (en) * | 1996-06-13 | 1999-07-27 | Mayo Foundation For Medical Education And Research | Bifunctional acetylcholinesterase reactivators |
GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
US6949575B2 (en) * | 2000-05-04 | 2005-09-27 | Pfizer Inc. | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives |
PL376476A1 (en) * | 2002-10-24 | 2005-12-27 | Merz Pharma Gmbh & Co.Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
US20050222123A1 (en) | 2004-01-27 | 2005-10-06 | North Shore-Long Island Jewish Research Institute | Cholinesterase inhibitors for treating inflammation |
JPWO2006004201A1 (ja) * | 2004-07-01 | 2008-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経再生促進剤 |
JP2008518955A (ja) * | 2004-11-02 | 2008-06-05 | ノースウェスタン ユニバーシティ | ピリダジン化合物および方法 |
ES2328384T3 (es) * | 2004-11-23 | 2009-11-12 | Warner-Lambert Company Llc | Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia. |
US20080171736A1 (en) * | 2004-12-23 | 2008-07-17 | Gregory Christopher W | Treatment of Alzheimer's Disease and Mild Cognitive impairment using GnRH-I analogs and one or more of acetylcholinesterase inhibitors and NMDA receptor antagonists |
CA2650711A1 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
CN103313712B (zh) | 2010-11-15 | 2016-10-26 | 艾吉因生物股份有限公司 | 用于治疗认知障碍的哒嗪衍生物、组合物和方法 |
US9459187B2 (en) | 2011-03-04 | 2016-10-04 | Becton, Dickinson And Company | Blood collection device containing lysophospholipase inhibitor |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
JP6883988B2 (ja) | 2013-12-20 | 2021-06-09 | エージンバイオ, インコーポレイテッド | ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法 |
CN107810002B (zh) | 2015-05-22 | 2021-01-05 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
IL256354B (en) | 2015-06-19 | 2022-09-01 | Agenebio Inc | History of benzodiazepines, preparations and their use for the treatment of cognitive impairment |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
EA202190076A1 (ru) | 2018-06-19 | 2021-09-22 | Эйджинбайо, Инк. | Производные бензодиазепина, композиции и способы лечения когнитивных нарушений |
KR101953366B1 (ko) | 2018-12-26 | 2019-02-28 | 정종문 | 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법 |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1629873A (en) * | 1919-07-08 | 1927-05-24 | Ig Farbenindustrie Ag | Acridine derivatives and process of making same |
US2083908A (en) * | 1933-03-23 | 1937-06-15 | Hata Sahachiro | Method of preparing 9-amino-3, 6-dimethoxy-10-methyl-acridinium chlorides |
US2083903A (en) * | 1936-04-27 | 1937-06-15 | Gerald William G Fitz | Tire chain |
US3043842A (en) * | 1959-02-09 | 1962-07-10 | Smith Kline French Lab | Substituted acridans |
CH420150A (de) * | 1961-12-18 | 1966-09-15 | Siegfried Ag | Verfahren zur Herstellung von 10-Aminoalkyl-5,5-dialkylacridanen |
NL6603826A (de) * | 1965-03-24 | 1966-09-26 | ||
DE1251764B (de) * | 1965-08-18 | 1967-10-12 | C H Boehnnger Sohn Ingelheim/ Rhein | Verfahren zur Herstellung von antimikrobiell wirksamen 12 3,4-Tetra hydro 9 -ammo acridmiumverbmdungen |
US3489837A (en) * | 1968-07-11 | 1970-01-13 | Leroy J Hyman | Synergistic antiseptic composition consisting of 9-aminoacridine hydrochloride and benzethonium chloride |
EP0179383B1 (de) * | 1984-10-25 | 1991-05-29 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-Amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel |
US4631286A (en) * | 1984-10-25 | 1986-12-23 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
-
1987
- 1987-09-24 US US07/098,871 patent/US4816456A/en not_active Expired - Lifetime
- 1987-09-28 AT AT87906711T patent/ATE106245T1/de active
- 1987-09-28 EP EP87906711A patent/EP0328535B1/de not_active Expired - Lifetime
- 1987-09-28 JP JP62506116A patent/JPH0655725B2/ja not_active Expired - Lifetime
- 1987-09-28 DE DE3789967T patent/DE3789967T2/de not_active Expired - Lifetime
- 1987-09-28 AU AU80707/87A patent/AU621035B2/en not_active Ceased
- 1987-09-28 WO PCT/US1987/002422 patent/WO1988002256A1/en active IP Right Grant
- 1987-09-28 EP EP93117982A patent/EP0595365A1/de not_active Withdrawn
- 1987-09-28 DE DE1995175031 patent/DE19575031I2/de active Active
- 1987-09-28 LU LU88749C patent/LU88749I2/fr unknown
- 1987-09-30 CA CA000548218A patent/CA1335813C/en not_active Expired - Fee Related
-
1988
- 1988-05-31 DK DK295888A patent/DK295888A/da unknown
-
1989
- 1989-03-31 FI FI891548A patent/FI891548A0/fi not_active Application Discontinuation
-
1992
- 1992-06-29 MX MX9203762A patent/MX9203762A/es unknown
-
1994
- 1994-11-17 AU AU78886/94A patent/AU671933B2/en not_active Ceased
-
1998
- 1998-01-22 HK HK98100563A patent/HK1001669A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU671933B2 (en) | 1996-09-12 |
ATE106245T1 (de) | 1994-06-15 |
LU88749I2 (fr) | 1996-08-23 |
DK295888D0 (da) | 1988-05-31 |
DE3789967D1 (de) | 1994-07-07 |
JPH0655725B2 (ja) | 1994-07-27 |
AU621035B2 (en) | 1992-03-05 |
WO1988002256A1 (en) | 1988-04-07 |
CA1335813C (en) | 1995-06-06 |
DK295888A (da) | 1988-06-07 |
FI891548A (fi) | 1989-03-31 |
EP0328535B1 (de) | 1994-06-01 |
EP0595365A1 (de) | 1994-05-04 |
HK1001669A1 (en) | 1998-07-03 |
AU7888694A (en) | 1995-02-09 |
FI891548A0 (fi) | 1989-03-31 |
DE3789967T2 (de) | 1994-09-22 |
JPH02500975A (ja) | 1990-04-05 |
US4816456A (en) | 1989-03-28 |
EP0328535A1 (de) | 1989-08-23 |
MX9203762A (es) | 1992-09-01 |
AU8070787A (en) | 1988-04-21 |
EP0328535A4 (en) | 1991-05-22 |
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