HK1001669A1 - The administration of monoamine acridines in cholinergic neuronal deficit states - Google Patents
The administration of monoamine acridines in cholinergic neuronal deficit statesInfo
- Publication number
- HK1001669A1 HK1001669A1 HK98100563A HK98100563A HK1001669A1 HK 1001669 A1 HK1001669 A1 HK 1001669A1 HK 98100563 A HK98100563 A HK 98100563A HK 98100563 A HK98100563 A HK 98100563A HK 1001669 A1 HK1001669 A1 HK 1001669A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hydrogen
- double bond
- substituent
- ethoxy
- methoxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91407686A | 1986-10-01 | 1986-10-01 | |
US07/098,871 US4816456A (en) | 1986-10-01 | 1987-09-24 | Administration of monoamine acridines in cholinergic neuronal deficit states |
PCT/US1987/002422 WO1988002256A1 (en) | 1986-10-01 | 1987-09-28 | The administration of monoamine acridines in cholinergic neuronal deficit states |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1001669A1 true HK1001669A1 (en) | 1998-07-03 |
Family
ID=26795215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98100563A HK1001669A1 (en) | 1986-10-01 | 1998-01-22 | The administration of monoamine acridines in cholinergic neuronal deficit states |
Country Status (13)
Country | Link |
---|---|
US (1) | US4816456A (de) |
EP (2) | EP0595365A1 (de) |
JP (1) | JPH0655725B2 (de) |
AT (1) | ATE106245T1 (de) |
AU (2) | AU621035B2 (de) |
CA (1) | CA1335813C (de) |
DE (2) | DE19575031I2 (de) |
DK (1) | DK295888A (de) |
FI (1) | FI891548A (de) |
HK (1) | HK1001669A1 (de) |
LU (1) | LU88749I2 (de) |
MX (1) | MX9203762A (de) |
WO (1) | WO1988002256A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
US4897400A (en) * | 1987-02-13 | 1990-01-30 | Hoeschst-Roussel Pharmaceuticals, Inc. | 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds useful for incresing the cholinergic function in a mammal |
PH25124A (en) * | 1987-03-17 | 1991-02-19 | Hoechst Roussel Pharma | Substituted 9-amino-tetrahydro acridines and related compounds |
US6075144A (en) | 1987-04-20 | 2000-06-13 | Hoechst Marion Roussel, Inc. | 9-hydroxyamino tetrahydroacridine and related compounds |
US5013741A (en) * | 1987-09-08 | 1991-05-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal |
US5037833A (en) * | 1988-07-25 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals Inc. | N-[substituted alkylidene]fused-bicycloalkylidene quinolinamines useful for enhancing the cholinergic function in a mammal |
US5008853A (en) | 1987-12-02 | 1991-04-16 | Xerox Corporation | Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment |
DE3889302T2 (de) | 1987-12-03 | 1994-10-20 | Mitsubishi Chem Ind | 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff. |
IE62871B1 (en) * | 1988-03-08 | 1995-03-08 | Warner Lambert Co | Compositions with enhanced penetration |
US5019395A (en) * | 1988-03-08 | 1991-05-28 | Warner-Lambert Company | Compositions with enhanced penetration |
AU621416B2 (en) * | 1988-11-16 | 1992-03-12 | Hoechst Marion Roussel, Inc. | Hydroxy-1,2,3,4-tetrahydroaminoacridines, a process for their preparation and their use as medicaments |
FR2651230B1 (fr) * | 1989-08-25 | 1992-03-13 | Synthese Rech | Derives de la 5-amino-1,2,3,4 tetrahydro-acridine et applications comme medicaments. |
US4994452A (en) * | 1989-11-28 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
US5112829A (en) * | 1989-11-28 | 1992-05-12 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
US5508280A (en) * | 1990-05-18 | 1996-04-16 | Merrell Pharmaceuticals, Inc. | 5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists |
US5610155A (en) * | 1992-04-09 | 1997-03-11 | Dr. Karl Thomae Gmbh | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation |
US5466696A (en) * | 1992-09-10 | 1995-11-14 | Warner Lambert Company | Tacrine and cytochrome P450 oxidase inhibitors and methods of use |
US5422350A (en) * | 1992-09-10 | 1995-06-06 | Warner-Lambert Company | Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use |
US5434170A (en) * | 1993-12-23 | 1995-07-18 | Andrulis Pharmaceuticals Corp. | Method for treating neurocognitive disorders |
US5698224A (en) * | 1994-06-27 | 1997-12-16 | Alza Corporation | Tacrine therapy |
DE19533089C1 (de) * | 1995-09-07 | 1997-05-22 | Hexal Ag | Tacrin-Pflaster |
US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
GB9524346D0 (en) * | 1995-11-29 | 1996-01-31 | Univ Strathclyde | Polycyclic compounds |
US5783584A (en) * | 1995-12-11 | 1998-07-21 | Mayo Foundation For Medical Education And Research | THA analogs useful as cholinesterase inhibitors |
US5929093A (en) * | 1996-06-13 | 1999-07-27 | Mayo Foundation For Medical Education And Research | Bifunctional acetylcholinesterase reactivators |
GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
ES2248315T3 (es) * | 2000-05-04 | 2006-03-16 | Warner-Lambert Company Llc | Procedimiento de inhibicion de la agregacion de proteinas amiloides y de formacion de imagenes de depositos de amiloides usando derivados aminoindanos. |
EA008863B1 (ru) * | 2002-10-24 | 2007-08-31 | Мерц Фарма Гмбх Унд Ко. Кгаа | Комбинированная терапия с использованием производных 1-аминоциклогексана и ингибиторов ацетилхолинэстеразы |
WO2005072713A2 (en) | 2004-01-27 | 2005-08-11 | The Feinstein Institute For Medical Research | Cholinesterase inhibitors for treating inflammation |
JPWO2006004201A1 (ja) * | 2004-07-01 | 2008-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経再生促進剤 |
WO2006050359A2 (en) * | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
CA2590533C (en) * | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
US20080171736A1 (en) * | 2004-12-23 | 2008-07-17 | Gregory Christopher W | Treatment of Alzheimer's Disease and Mild Cognitive impairment using GnRH-I analogs and one or more of acetylcholinesterase inhibitors and NMDA receptor antagonists |
CA2650711A1 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
WO2011100373A1 (en) * | 2010-02-09 | 2011-08-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
JP5916746B2 (ja) | 2010-11-15 | 2016-05-11 | エージンバイオ, インコーポレイテッド | 認知障害を処置するためのピリダジン誘導体、組成物、および方法 |
BR112013022662B1 (pt) | 2011-03-04 | 2021-11-23 | Becton, Dickinson And Company | Dispositivo de coleta de sangue contendo inibidor de lisofosfolipase e métodos para diagnosticar uma doença metabólica ou monitorar o tratamento de um paciente com uma doença metabólica e para detectar a presença ou quantidade de um pró-fármaco e/ou metabólito ativo do mesmo no sangue ou componente do mesmo |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
EP2968237A4 (de) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion |
CA2934553C (en) | 2013-12-20 | 2023-10-31 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
AU2016268096B2 (en) | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
IL256354B (en) | 2015-06-19 | 2022-09-01 | Agenebio Inc | History of benzodiazepines, preparations and their use for the treatment of cognitive impairment |
US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
BR112020026062B1 (pt) | 2018-06-19 | 2023-04-04 | Agenebio, Inc | Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson |
KR101953366B1 (ko) | 2018-12-26 | 2019-02-28 | 정종문 | 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법 |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1629873A (en) * | 1919-07-08 | 1927-05-24 | Ig Farbenindustrie Ag | Acridine derivatives and process of making same |
US2083908A (en) * | 1933-03-23 | 1937-06-15 | Hata Sahachiro | Method of preparing 9-amino-3, 6-dimethoxy-10-methyl-acridinium chlorides |
US2083903A (en) * | 1936-04-27 | 1937-06-15 | Gerald William G Fitz | Tire chain |
US3043842A (en) * | 1959-02-09 | 1962-07-10 | Smith Kline French Lab | Substituted acridans |
CH420150A (de) * | 1961-12-18 | 1966-09-15 | Siegfried Ag | Verfahren zur Herstellung von 10-Aminoalkyl-5,5-dialkylacridanen |
NL6603826A (de) * | 1965-03-24 | 1966-09-26 | ||
DE1251764B (de) * | 1965-08-18 | 1967-10-12 | C H Boehnnger Sohn Ingelheim/ Rhein | Verfahren zur Herstellung von antimikrobiell wirksamen 12 3,4-Tetra hydro 9 -ammo acridmiumverbmdungen |
US3489837A (en) * | 1968-07-11 | 1970-01-13 | Leroy J Hyman | Synergistic antiseptic composition consisting of 9-aminoacridine hydrochloride and benzethonium chloride |
US4631286A (en) * | 1984-10-25 | 1986-12-23 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
ATE63903T1 (de) * | 1984-10-25 | 1991-06-15 | Hoechst Roussel Pharma | 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel. |
-
1987
- 1987-09-24 US US07/098,871 patent/US4816456A/en not_active Expired - Lifetime
- 1987-09-28 AT AT87906711T patent/ATE106245T1/de active
- 1987-09-28 EP EP93117982A patent/EP0595365A1/de not_active Withdrawn
- 1987-09-28 JP JP62506116A patent/JPH0655725B2/ja not_active Expired - Lifetime
- 1987-09-28 EP EP87906711A patent/EP0328535B1/de not_active Expired - Lifetime
- 1987-09-28 WO PCT/US1987/002422 patent/WO1988002256A1/en active IP Right Grant
- 1987-09-28 DE DE1995175031 patent/DE19575031I2/de active Active
- 1987-09-28 AU AU80707/87A patent/AU621035B2/en not_active Ceased
- 1987-09-28 LU LU88749C patent/LU88749I2/fr unknown
- 1987-09-28 DE DE3789967T patent/DE3789967T2/de not_active Expired - Lifetime
- 1987-09-30 CA CA000548218A patent/CA1335813C/en not_active Expired - Fee Related
-
1988
- 1988-05-31 DK DK295888A patent/DK295888A/da unknown
-
1989
- 1989-03-31 FI FI891548A patent/FI891548A/fi not_active Application Discontinuation
-
1992
- 1992-06-29 MX MX9203762A patent/MX9203762A/es unknown
-
1994
- 1994-11-17 AU AU78886/94A patent/AU671933B2/en not_active Ceased
-
1998
- 1998-01-22 HK HK98100563A patent/HK1001669A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0328535B1 (de) | 1994-06-01 |
DK295888D0 (da) | 1988-05-31 |
MX9203762A (es) | 1992-09-01 |
JPH02500975A (ja) | 1990-04-05 |
JPH0655725B2 (ja) | 1994-07-27 |
US4816456A (en) | 1989-03-28 |
AU621035B2 (en) | 1992-03-05 |
DE3789967D1 (de) | 1994-07-07 |
EP0595365A1 (de) | 1994-05-04 |
FI891548A0 (fi) | 1989-03-31 |
EP0328535A1 (de) | 1989-08-23 |
EP0328535A4 (en) | 1991-05-22 |
CA1335813C (en) | 1995-06-06 |
DE19575031I2 (de) | 2003-05-22 |
WO1988002256A1 (en) | 1988-04-07 |
FI891548A (fi) | 1989-03-31 |
LU88749I2 (fr) | 1996-08-23 |
ATE106245T1 (de) | 1994-06-15 |
DK295888A (da) | 1988-06-07 |
AU8070787A (en) | 1988-04-21 |
DE3789967T2 (de) | 1994-09-22 |
AU671933B2 (en) | 1996-09-12 |
AU7888694A (en) | 1995-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0328535A4 (en) | The administration of monoamine acridines in cholinergic neuronal deficit states | |
AP2001002079A0 (en) | Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents. | |
MY108885A (en) | Heterocyclic-cyclic amine derivatives. | |
DE69923849D1 (de) | Quinolin-2-on-derivate verwendbar als antikrebsmittel | |
MY101541A (en) | Indolizine derivatives, process for preparing them and the compositions containing them | |
HK1040392A1 (zh) | 用於治療腦血管疾患的黃嘌呤衍生物 | |
DE69130412D1 (de) | Pyrazolopyridinverbindung und Verfahren zu ihrer Herstellung | |
ES468119A1 (es) | Un procedimiento para la preparacion de triazinas | |
EP0614661A3 (de) | Benzyliden- und Cinnamyliden-Malononitril-Derivate zur Hemmung der Proliferativen Prozesse in Säugetierzellen. | |
MY104335A (en) | 4-aminophridine deravatives | |
DE69227088D1 (de) | Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln | |
IL106387A0 (en) | Indole derivatives,their preparation and pharmaceutical compositions containing them | |
ES2012736A6 (es) | Procedimiento para la preparacion de derivados triciclicos de 3-oxopropanonitrilo. | |
EP0186023A3 (de) | Gallensäurederivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen die sie enthalten | |
DE3850437D1 (de) | Benzo- und Thieno-3,4-dihydro-pyridinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel. | |
ATE5961T1 (de) | N-acylpeptid-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. | |
ATE123487T1 (de) | Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen. | |
NO963374L (no) | Substituerte 4H-pyraner | |
NZ220543A (en) | Ergoline derivatives and pharmaceutical compositions | |
FR2694557B1 (fr) | Dérivés de tétrahydronaphtalène, leur préparation, et leur application en thérapeutique. | |
FR2708604A1 (fr) | Utilisation de dérivés de benzènesulfonyl-indole pour la préparation de médicaments. | |
ES8707939A1 (es) | Procedimiento para preparar derivados de n-carboxialquil-2--oxo-3-diaril-5,6-triazinas | |
PL304334A1 (en) | Pharmaceutical composition of gastric protective action, including antiulceric one and method of treating diseases of gastrointestinal tract |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |