HUP0003215A2 - Farnezil-protein-transzferáz új fenil-szubsztituált triciklusos inhibitorai - Google Patents
Farnezil-protein-transzferáz új fenil-szubsztituált triciklusos inhibitoraiInfo
- Publication number
- HUP0003215A2 HUP0003215A2 HU0003215A HUP0003215A HUP0003215A2 HU P0003215 A2 HUP0003215 A2 HU P0003215A2 HU 0003215 A HU0003215 A HU 0003215A HU P0003215 A HUP0003215 A HU P0003215A HU P0003215 A2 HUP0003215 A2 HU P0003215A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen
- atom
- protein transferase
- farnesyl
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052799 carbon Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát az (1.0) általános képletű új, fenil-szubsztituálttriciklusos vegyületek -, ahol a szaggatott vonal adott esetben jelenlevő kettős kötést jelent, és előnyösen, bizonyos feltételekkel Anitrogénatom vagy N-oxiddá oxidált nitrogénatom; X nitrogén- vagyszénatom vagy metincsoport; R1 hidrogén- vagy halogénatom, alkil-,cikloalkil- vagy alkenilcsoport; R2 hidrogén- vagy halogénatom,alkoxi- vagy alkilcsoport; R3 hidrogén- vagy halogénatom, alkoxi-,hidroxi- vagy alkilcsoport; R4, R5, R6, R7 és R8 hidrogénatom; Qhidrogénatom vagy hidroxicsoport, vagy elhagyjuk a képletből; és Ymetil-szulfonil-csoport vagy -COR általános képletű csoport, amelybenR heteroaril-alkil- vagy heterocikloalkil-alkil-csoport - és sóik vagyszolvátjaik, ezeket tartalmazó gyógyszerkészítmények, és a farnezil-protein-transzferáz gátlására, valamint daganatos betegségekkezelésére való alkalmazásuk képezik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87705297A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011509 WO1998057950A1 (en) | 1997-06-17 | 1998-06-15 | Novel phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0003215A2 true HUP0003215A2 (hu) | 2001-06-28 |
Family
ID=25369151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003215A HUP0003215A2 (hu) | 1997-06-17 | 1998-06-15 | Farnezil-protein-transzferáz új fenil-szubsztituált triciklusos inhibitorai |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0989981A1 (hu) |
| JP (1) | JP2002504150A (hu) |
| KR (1) | KR20010013945A (hu) |
| CN (1) | CN1267292A (hu) |
| AU (1) | AU8253798A (hu) |
| CA (1) | CA2293549C (hu) |
| HU (1) | HUP0003215A2 (hu) |
| IL (1) | IL133446A0 (hu) |
| NZ (1) | NZ501613A (hu) |
| WO (1) | WO1998057950A1 (hu) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| DE69429438T2 (de) * | 1993-10-15 | 2002-08-08 | Schering Corp., Kenilworth | Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen |
| WO1995010514A1 (en) * | 1993-10-15 | 1995-04-20 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| PL185597B1 (pl) * | 1995-12-22 | 2003-06-30 | Schering Corp | Tricykliczne amidy, środek farmaceutyczny i ich zastosowania |
-
1998
- 1998-06-15 EP EP98932719A patent/EP0989981A1/en not_active Withdrawn
- 1998-06-15 HU HU0003215A patent/HUP0003215A2/hu unknown
- 1998-06-15 WO PCT/US1998/011509 patent/WO1998057950A1/en not_active Application Discontinuation
- 1998-06-15 NZ NZ501613A patent/NZ501613A/en unknown
- 1998-06-15 IL IL13344698A patent/IL133446A0/xx unknown
- 1998-06-15 AU AU82537/98A patent/AU8253798A/en not_active Abandoned
- 1998-06-15 CA CA002293549A patent/CA2293549C/en not_active Expired - Fee Related
- 1998-06-15 CN CN98808215A patent/CN1267292A/zh active Pending
- 1998-06-15 JP JP50450399A patent/JP2002504150A/ja not_active Ceased
- 1998-06-15 KR KR1019997011970A patent/KR20010013945A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002504150A (ja) | 2002-02-05 |
| EP0989981A1 (en) | 2000-04-05 |
| WO1998057950A1 (en) | 1998-12-23 |
| CA2293549C (en) | 2008-08-05 |
| CA2293549A1 (en) | 1998-12-23 |
| NZ501613A (en) | 2001-11-30 |
| KR20010013945A (ko) | 2001-02-26 |
| AU8253798A (en) | 1999-01-04 |
| CN1267292A (zh) | 2000-09-20 |
| IL133446A0 (en) | 2001-04-30 |
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