DE1953995A1 - Desensibilisierungsmittel gegen Allergien und Verfahren zu seiner Herstellung - Google Patents
Desensibilisierungsmittel gegen Allergien und Verfahren zu seiner HerstellungInfo
- Publication number
- DE1953995A1 DE1953995A1 DE19691953995 DE1953995A DE1953995A1 DE 1953995 A1 DE1953995 A1 DE 1953995A1 DE 19691953995 DE19691953995 DE 19691953995 DE 1953995 A DE1953995 A DE 1953995A DE 1953995 A1 DE1953995 A1 DE 1953995A1
- Authority
- DE
- Germany
- Prior art keywords
- allergen
- acid ester
- pollen
- extract
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010020751 Hypersensitivity Diseases 0.000 title claims description 18
- 238000000034 method Methods 0.000 title claims description 16
- 230000007815 allergy Effects 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title claims description 13
- 208000026935 allergic disease Diseases 0.000 title claims description 11
- 229940090898 Desensitizer Drugs 0.000 title claims description 8
- 239000013566 allergen Substances 0.000 claims description 42
- 239000002253 acid Substances 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- -1 aralkyl chloroformate Chemical compound 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 239000007853 buffer solution Substances 0.000 claims description 5
- 239000000460 chlorine Chemical group 0.000 claims description 4
- 238000000586 desensitisation Methods 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 239000011737 fluorine Substances 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- 239000006286 aqueous extract Substances 0.000 claims 2
- 229910052740 iodine Chemical group 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical class C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 244000007853 Sarothamnus scoparius Species 0.000 claims 1
- 230000002009 allergenic effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000284 extract Substances 0.000 description 22
- 239000000243 solution Substances 0.000 description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 241000700198 Cavia Species 0.000 description 9
- 239000007858 starting material Substances 0.000 description 9
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 8
- 241000746983 Phleum pratense Species 0.000 description 8
- 229960004784 allergens Drugs 0.000 description 8
- 244000152045 Themeda triandra Species 0.000 description 7
- 208000010668 atopic eczema Diseases 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000000172 allergic effect Effects 0.000 description 6
- 229940046528 grass pollen Drugs 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 244000025254 Cannabis sativa Species 0.000 description 5
- 101100449439 Drosophila melanogaster grass gene Proteins 0.000 description 5
- 239000003975 dentin desensitizing agent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 229940074608 allergen extract Drugs 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000007974 sodium acetate buffer Substances 0.000 description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 description 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000003455 anaphylaxis Diseases 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 208000024780 Urticaria Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000001045 blue dye Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000013573 pollen allergen Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 240000004585 Dactylis glomerata Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 240000000389 Leymus arenarius Species 0.000 description 1
- 235000015892 Leymus arenarius Nutrition 0.000 description 1
- 240000004296 Lolium perenne Species 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000746981 Phleum Species 0.000 description 1
- 229910020175 SiOH Inorganic materials 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- BPHHNXJPFPEJOF-UHFFFAOYSA-J chembl296966 Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC(S([O-])(=O)=O)=C(N)C2=C(O)C(N=NC3=CC=C(C=C3OC)C=3C=C(C(=CC=3)N=NC=3C(=C4C(N)=C(C=C(C4=CC=3)S([O-])(=O)=O)S([O-])(=O)=O)O)OC)=CC=C21 BPHHNXJPFPEJOF-UHFFFAOYSA-J 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- GCFAUZGWPDYAJN-UHFFFAOYSA-N cyclohexyl 3-phenylprop-2-enoate Chemical compound C=1C=CC=CC=1C=CC(=O)OC1CCCCC1 GCFAUZGWPDYAJN-UHFFFAOYSA-N 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical compound C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000013574 grass pollen allergen Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 229940124452 immunizing agent Drugs 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5064568A GB1243832A (en) | 1968-10-25 | 1968-10-25 | Vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1953995A1 true DE1953995A1 (de) | 1970-04-30 |
Family
ID=10456759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19691953995 Pending DE1953995A1 (de) | 1968-10-25 | 1969-10-27 | Desensibilisierungsmittel gegen Allergien und Verfahren zu seiner Herstellung |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT293617B (enrdf_load_stackoverflow) |
| BE (1) | BE740801A (enrdf_load_stackoverflow) |
| CH (1) | CH536633A (enrdf_load_stackoverflow) |
| DE (1) | DE1953995A1 (enrdf_load_stackoverflow) |
| DK (1) | DK125308B (enrdf_load_stackoverflow) |
| ES (1) | ES372843A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2021556B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1243832A (enrdf_load_stackoverflow) |
| IE (1) | IE33603B1 (enrdf_load_stackoverflow) |
| NL (1) | NL6916121A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2178582A1 (es) * | 2000-12-01 | 2002-12-16 | Lozano Juan Jose Martin | Perfil copa, para el montaje a dos pisos de cuadros electricos. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1174854A (en) * | 1967-07-07 | 1969-12-17 | Miles Lab | New Biologically Active Conjugates |
-
1968
- 1968-10-25 GB GB5064568A patent/GB1243832A/en not_active Expired
-
1969
- 1969-10-20 IE IE143069A patent/IE33603B1/xx unknown
- 1969-10-23 DK DK561269A patent/DK125308B/da unknown
- 1969-10-23 FR FR6936324A patent/FR2021556B1/fr not_active Expired
- 1969-10-24 AT AT1003869A patent/AT293617B/de not_active IP Right Cessation
- 1969-10-24 BE BE740801D patent/BE740801A/xx unknown
- 1969-10-24 ES ES372843A patent/ES372843A1/es not_active Expired
- 1969-10-24 NL NL6916121A patent/NL6916121A/xx unknown
- 1969-10-25 CH CH1589469A patent/CH536633A/de not_active IP Right Cessation
- 1969-10-27 DE DE19691953995 patent/DE1953995A1/de active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2178582A1 (es) * | 2000-12-01 | 2002-12-16 | Lozano Juan Jose Martin | Perfil copa, para el montaje a dos pisos de cuadros electricos. |
Also Published As
| Publication number | Publication date |
|---|---|
| CH536633A (de) | 1973-05-15 |
| GB1243832A (en) | 1971-08-25 |
| FR2021556A1 (enrdf_load_stackoverflow) | 1970-07-24 |
| FR2021556B1 (enrdf_load_stackoverflow) | 1973-01-12 |
| BE740801A (enrdf_load_stackoverflow) | 1970-04-24 |
| IE33603B1 (en) | 1974-08-21 |
| AT293617B (de) | 1971-10-25 |
| ES372843A1 (es) | 1971-11-01 |
| NL6916121A (enrdf_load_stackoverflow) | 1970-04-28 |
| IE33603L (en) | 1970-04-25 |
| DK125308B (da) | 1973-02-05 |
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