GB1174854A - New Biologically Active Conjugates - Google Patents
New Biologically Active ConjugatesInfo
- Publication number
- GB1174854A GB1174854A GB31374/67A GB3137467A GB1174854A GB 1174854 A GB1174854 A GB 1174854A GB 31374/67 A GB31374/67 A GB 31374/67A GB 3137467 A GB3137467 A GB 3137467A GB 1174854 A GB1174854 A GB 1174854A
- Authority
- GB
- United Kingdom
- Prior art keywords
- extract
- acid
- biologically active
- pollen extract
- naja
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1,174,854. Antigenic and therapeutic materials. MILES LABORATORIES Inc. 23 Aug., 1968 [7 July, 1967], No. 31374/67. Heading A5B. [Also in Division C3] An therapeutic preparation for injection comprises a sterile solution of the sodium salt of a conjugate of a polysaccharide containing acid groups and which forms a water-soluble sodium salt and a water-insoluble calcium salt and a biologically active substance containing basic amino or phenolic hydroxy groups to which it is linked via amide and/or ester linkages such that the final product still contains free acid groups and forms salts as defined above. Specified polysaccharides are pectin, pectic acid, alginic acid, celluronic acid, carageenan and lickerin uronic acid. Biologically active substances used in the examples are insulin, ovalbumin, timothy pollen extract, trypsin, cocksfoot pollen extract, ragweed pollen extract, diphtheria toxin, birch pollen extract, horse dander extract, cat epithalial extract, lactalbumin, haddock extract, dry rot extract, Baker's yeast extract, Naja-Naja venom, bee venom, tetanus toxoid, ficin and chymotrypsin. Reaction may be effected in aqueous solution using a coupling agent to form the amide and/or ester linkages.
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB31374/67A GB1174854A (en) | 1967-07-07 | 1967-07-07 | New Biologically Active Conjugates |
IL30258A IL30258A (en) | 1967-07-07 | 1968-06-26 | New conjugates of acid polysaccharides and complex organic substances |
CH998868A CH526590A (en) | 1967-07-07 | 1968-07-04 | Conjugates of biologicals with acidic polysaccharides |
BE717689D BE717689A (en) | 1967-07-07 | 1968-07-05 | |
LU56423D LU56423A1 (en) | 1967-07-07 | 1968-07-05 | |
DE1768841A DE1768841C3 (en) | 1967-07-07 | 1968-07-05 | Covalently bound conjugates of acidic polysaccharides and complex organic substances |
NL6809538.A NL160723C (en) | 1967-07-07 | 1968-07-05 | PROCESS FOR PREPARING AN IMMUNOLOGICALLY ACTIVE ORGANIC COMPOUND. |
SE6809321A SE383100B (en) | 1967-07-07 | 1968-07-05 | PROCEDURE FOR THE PREPARATION OF IMMUNOLOGICALLY ACTIVE CONJUGATES OF ALLERGENS OR TOXIC SUBSTANCES |
FR1584763D FR1584763A (en) | 1967-07-07 | 1968-07-05 | |
ES355853A ES355853A1 (en) | 1967-07-07 | 1968-07-06 | New Biologically Active Conjugates |
FR168874A FR7784M (en) | 1967-07-07 | 1968-10-04 | |
US05/278,880 US4003792A (en) | 1967-07-01 | 1972-08-08 | Conjugates of acid polysaccharides and complex organic substances |
SE7511288A SE400652B (en) | 1967-07-07 | 1975-10-08 | METHOD OF MAKING CONJUGATE OF INSULIN WITH ACIDIC POLYSACCARIDES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB31374/67A GB1174854A (en) | 1967-07-07 | 1967-07-07 | New Biologically Active Conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1174854A true GB1174854A (en) | 1969-12-17 |
Family
ID=10322153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB31374/67A Expired GB1174854A (en) | 1967-07-01 | 1967-07-07 | New Biologically Active Conjugates |
Country Status (10)
Country | Link |
---|---|
BE (1) | BE717689A (en) |
CH (1) | CH526590A (en) |
DE (1) | DE1768841C3 (en) |
ES (1) | ES355853A1 (en) |
FR (2) | FR1584763A (en) |
GB (1) | GB1174854A (en) |
IL (1) | IL30258A (en) |
LU (1) | LU56423A1 (en) |
NL (1) | NL160723C (en) |
SE (2) | SE383100B (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4003792A (en) | 1967-07-01 | 1977-01-18 | Miles Laboratories, Inc. | Conjugates of acid polysaccharides and complex organic substances |
DE3032488A1 (en) * | 1979-09-05 | 1981-04-02 | Kabushiki Kaisha Hayashibara, Seibutsu-Kagaku Kenkyujo, Okayama | METHOD FOR PRODUCING A VACCINE |
US4663287A (en) * | 1983-06-15 | 1987-05-05 | Gist-Brocades N.V. | Biologically active conjugates and their preparation and use |
GB2270920A (en) * | 1992-09-25 | 1994-03-30 | Univ Keele | Alginate-bioactive agent conjugates |
US5384256A (en) * | 1992-04-25 | 1995-01-24 | Nestec S.A. | Pectin-modified lipase from Mucor javanicus with lowered saturated/unsaturated fatty acid ratio |
US5393538A (en) * | 1992-04-25 | 1995-02-28 | Nestec S.A. | Preparation of crumb-flavored milk chocolate |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1243832A (en) * | 1968-10-25 | 1971-08-25 | Beecham Group Ltd | Vaccines |
US3957580A (en) * | 1974-03-27 | 1976-05-18 | Pfizer Inc. | Immobilized microbial cells |
JPS57136528A (en) * | 1981-02-09 | 1982-08-23 | Hayashibara Biochem Lab Inc | Preparation of viral vaccine |
DE3443877A1 (en) * | 1984-06-09 | 1985-12-12 | Hoechst Ag | Insulin preparations, process for their preparation, and their use |
IT1203814B (en) * | 1986-06-30 | 1989-02-23 | Fidia Farmaceutici | ESTERS OF ALGINIC ACID |
FR2817870B1 (en) * | 2000-12-08 | 2006-07-28 | Skw Nature Products Holding Fr | CONJUGATED POLYMERS BASED ON PECTINES AND THEIR APPLICATION AS EMULSIFIERS |
-
1967
- 1967-07-07 GB GB31374/67A patent/GB1174854A/en not_active Expired
-
1968
- 1968-06-26 IL IL30258A patent/IL30258A/en unknown
- 1968-07-04 CH CH998868A patent/CH526590A/en not_active IP Right Cessation
- 1968-07-05 NL NL6809538.A patent/NL160723C/en not_active IP Right Cessation
- 1968-07-05 LU LU56423D patent/LU56423A1/xx unknown
- 1968-07-05 FR FR1584763D patent/FR1584763A/fr not_active Expired
- 1968-07-05 SE SE6809321A patent/SE383100B/en unknown
- 1968-07-05 BE BE717689D patent/BE717689A/xx not_active IP Right Cessation
- 1968-07-05 DE DE1768841A patent/DE1768841C3/en not_active Expired
- 1968-07-06 ES ES355853A patent/ES355853A1/en not_active Expired
- 1968-10-04 FR FR168874A patent/FR7784M/fr not_active Expired
-
1975
- 1975-10-08 SE SE7511288A patent/SE400652B/en unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4003792A (en) | 1967-07-01 | 1977-01-18 | Miles Laboratories, Inc. | Conjugates of acid polysaccharides and complex organic substances |
DE3032488A1 (en) * | 1979-09-05 | 1981-04-02 | Kabushiki Kaisha Hayashibara, Seibutsu-Kagaku Kenkyujo, Okayama | METHOD FOR PRODUCING A VACCINE |
US4663287A (en) * | 1983-06-15 | 1987-05-05 | Gist-Brocades N.V. | Biologically active conjugates and their preparation and use |
US5384256A (en) * | 1992-04-25 | 1995-01-24 | Nestec S.A. | Pectin-modified lipase from Mucor javanicus with lowered saturated/unsaturated fatty acid ratio |
US5393538A (en) * | 1992-04-25 | 1995-02-28 | Nestec S.A. | Preparation of crumb-flavored milk chocolate |
GB2270920A (en) * | 1992-09-25 | 1994-03-30 | Univ Keele | Alginate-bioactive agent conjugates |
GB2270920B (en) * | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
US5622718A (en) * | 1992-09-25 | 1997-04-22 | Keele University | Alginate-bioactive agent conjugates |
Also Published As
Publication number | Publication date |
---|---|
SE383100B (en) | 1976-03-01 |
FR7784M (en) | 1970-03-23 |
SE7511288L (en) | 1975-10-08 |
DE1768841A1 (en) | 1971-11-18 |
DE1768841C3 (en) | 1980-09-25 |
SE400652B (en) | 1978-04-03 |
NL160723B (en) | 1979-07-16 |
IL30258A (en) | 1972-02-29 |
DE1768841B2 (en) | 1980-01-31 |
BE717689A (en) | 1968-12-16 |
LU56423A1 (en) | 1968-10-21 |
CH526590A (en) | 1972-08-15 |
ES355853A1 (en) | 1970-03-01 |
NL160723C (en) | 1979-12-17 |
FR1584763A (en) | 1970-01-02 |
NL6809538A (en) | 1969-01-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PE20 | Patent expired after termination of 20 years |