DE1792625B2 - Verfahren zur Herstellung eines Desensibilisierungsmittels - Google Patents
Verfahren zur Herstellung eines DesensibilisierungsmittelsInfo
- Publication number
- DE1792625B2 DE1792625B2 DE1792625A DE1792625A DE1792625B2 DE 1792625 B2 DE1792625 B2 DE 1792625B2 DE 1792625 A DE1792625 A DE 1792625A DE 1792625 A DE1792625 A DE 1792625A DE 1792625 B2 DE1792625 B2 DE 1792625B2
- Authority
- DE
- Germany
- Prior art keywords
- solution
- aluminum hydroxide
- preparation
- allergen
- dust
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000002360 preparation method Methods 0.000 title claims description 18
- 238000000034 method Methods 0.000 title claims description 11
- 229940090898 Desensitizer Drugs 0.000 title 1
- 239000013566 allergen Substances 0.000 claims description 16
- 239000000428 dust Substances 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 9
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 8
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 8
- 229940024546 aluminum hydroxide gel Drugs 0.000 claims description 8
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 210000003746 feather Anatomy 0.000 claims description 3
- 239000003975 dentin desensitizing agent Substances 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 38
- 239000011734 sodium Substances 0.000 description 12
- 239000000427 antigen Substances 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 239000000284 extract Substances 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 238000000586 desensitisation Methods 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 206010020751 Hypersensitivity Diseases 0.000 description 6
- 230000007815 allergy Effects 0.000 description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 208000026935 allergic disease Diseases 0.000 description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 5
- 235000011130 ammonium sulphate Nutrition 0.000 description 5
- 230000003111 delayed effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 206010048908 Seasonal allergy Diseases 0.000 description 2
- 208000028004 allergic respiratory disease Diseases 0.000 description 2
- 230000002052 anaphylactic effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 201000004335 respiratory allergy Diseases 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000001235 sensitizing effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 1
- 229910017119 AlPO Inorganic materials 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- 235000003301 Ceiba pentandra Nutrition 0.000 description 1
- 244000146553 Ceiba pentandra Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 201000004338 pollen allergy Diseases 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR122285 | 1967-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE1792625A1 DE1792625A1 (de) | 1971-12-16 |
| DE1792625B2 true DE1792625B2 (de) | 1980-05-14 |
Family
ID=8638988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1792625A Ceased DE1792625B2 (de) | 1967-09-26 | 1968-09-26 | Verfahren zur Herstellung eines Desensibilisierungsmittels |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3629400A (enExample) |
| AT (1) | AT283592B (enExample) |
| BE (1) | BE721148A (enExample) |
| CH (1) | CH518719A (enExample) |
| DE (1) | DE1792625B2 (enExample) |
| DK (1) | DK123690B (enExample) |
| FR (1) | FR1604135A (enExample) |
| GB (1) | GB1240130A (enExample) |
| LU (1) | LU56840A1 (enExample) |
| NL (1) | NL6813607A (enExample) |
| YU (1) | YU39702B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK140815B (da) * | 1975-06-10 | 1979-11-19 | Weeke Bengt | Fremgangsmåde til påvisning eller bestemmelse af antistoffer i legemsvæsker ved hjælp af kendte antigener eller til bestemmelse af antigener ved hjælp af kendte antistoffer fra legemsvæsker samt et middel til anvendelse ved udøvelse af fremgangsmåden. |
-
1967
- 1967-09-26 FR FR122285A patent/FR1604135A/fr not_active Expired
-
1968
- 1968-09-06 LU LU56840A patent/LU56840A1/xx unknown
- 1968-09-18 CH CH1395468A patent/CH518719A/fr not_active IP Right Cessation
- 1968-09-19 GB GB44535/68A patent/GB1240130A/en not_active Expired
- 1968-09-20 US US761329A patent/US3629400A/en not_active Expired - Lifetime
- 1968-09-20 BE BE721148D patent/BE721148A/xx not_active IP Right Cessation
- 1968-09-23 YU YU2218/68A patent/YU39702B/xx unknown
- 1968-09-24 NL NL6813607A patent/NL6813607A/xx unknown
- 1968-09-25 DK DK461468AA patent/DK123690B/da unknown
- 1968-09-25 AT AT935268A patent/AT283592B/de not_active IP Right Cessation
- 1968-09-26 DE DE1792625A patent/DE1792625B2/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CH518719A (fr) | 1972-02-15 |
| US3629400A (en) | 1971-12-21 |
| AT283592B (de) | 1970-08-10 |
| BE721148A (enExample) | 1969-03-03 |
| LU56840A1 (enExample) | 1968-12-17 |
| YU39702B (en) | 1985-04-30 |
| YU221868A (en) | 1983-06-30 |
| NL6813607A (enExample) | 1969-03-28 |
| DE1792625A1 (de) | 1971-12-16 |
| DK123690B (da) | 1972-07-24 |
| FR1604135A (enExample) | 1971-07-12 |
| GB1240130A (en) | 1971-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8235 | Patent refused |