DE1770062C3 - Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen - Google Patents

Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen

Info

Publication number
DE1770062C3
DE1770062C3 DE1770062A DE1770062A DE1770062C3 DE 1770062 C3 DE1770062 C3 DE 1770062C3 DE 1770062 A DE1770062 A DE 1770062A DE 1770062 A DE1770062 A DE 1770062A DE 1770062 C3 DE1770062 C3 DE 1770062C3
Authority
DE
Germany
Prior art keywords
acid
benzyl
penicillin
tetrahydroisoquinaldic
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1770062A
Other languages
German (de)
English (en)
Other versions
DE1770062B2 (de
DE1770062A1 (de
Inventor
Daniel Dr.-Ing. Montrouge Bertin
Andre Noisy-Le-Sec Pierdet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of DE1770062A1 publication Critical patent/DE1770062A1/de
Publication of DE1770062B2 publication Critical patent/DE1770062B2/de
Application granted granted Critical
Publication of DE1770062C3 publication Critical patent/DE1770062C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE1770062A 1967-03-29 1968-03-26 Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen Expired DE1770062C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR100617A FR1525186A (fr) 1967-03-29 1967-03-29 Nouvelles pénicillines et procédé de préparation
FR138141A FR7155M (OSRAM) 1967-03-29 1968-01-31

Publications (3)

Publication Number Publication Date
DE1770062A1 DE1770062A1 (de) 1971-09-16
DE1770062B2 DE1770062B2 (de) 1978-11-30
DE1770062C3 true DE1770062C3 (de) 1979-08-02

Family

ID=26175147

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1770062A Expired DE1770062C3 (de) 1967-03-29 1968-03-26 Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen

Country Status (8)

Country Link
US (1) US3494917A (OSRAM)
CH (1) CH491958A (OSRAM)
DE (1) DE1770062C3 (OSRAM)
DK (1) DK118021B (OSRAM)
FR (2) FR1525186A (OSRAM)
GB (2) GB1209668A (OSRAM)
IL (1) IL29661A (OSRAM)
NL (1) NL144944B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531615D0 (en) * 1985-12-23 1986-02-05 Zambeletti Spa L Compounds
HU212427B (en) * 1991-12-19 1996-06-28 Gyogyszerkutato Intezet Process for producing dl-, d- and l-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids and their derivatives containing urethane-type n-protecting groups
WO2013056034A1 (en) 2011-10-14 2013-04-18 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
EP2899183B1 (en) 2011-10-14 2018-09-19 Bristol-Myers Squibb Company Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors
HRP20170784T8 (hr) 2011-10-14 2018-05-18 Bristol-Myers Squibb Company Supstituirani spojevi tetrahidroizohinolina kao inhbitori xia faktora
EP2906541B1 (en) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
US9315519B2 (en) 2012-10-12 2016-04-19 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
HRP20180465T1 (hr) 2012-10-12 2018-05-04 Bristol-Myers Squibb Company Kristalni oblici inhibitora faktora xia
JP6479763B2 (ja) 2013-03-25 2019-03-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン
UY35971A (es) 2014-01-31 2015-07-31 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Macrociclos con grupos p2? aromáticos como inhibidores del factor xia
NO2760821T3 (OSRAM) 2014-01-31 2018-03-10
CN107074821B (zh) 2014-09-04 2020-05-22 百时美施贵宝公司 为fxia抑制剂的二酰胺大环化合物
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3174964A (en) * 1959-12-10 1965-03-23 Pfizer & Co C Derivatives of 6-aminopenicillanic acid
US3043831A (en) * 1960-07-18 1962-07-10 Doyle Frank Peter Synthetic penicillins

Also Published As

Publication number Publication date
FR1525186A (fr) 1968-05-17
CH491958A (fr) 1970-06-15
DE1770062B2 (de) 1978-11-30
GB1209668A (en) 1970-10-21
GB1209669A (en) 1970-10-21
FR7155M (OSRAM) 1969-08-04
NL6804392A (OSRAM) 1968-09-30
DE1770062A1 (de) 1971-09-16
IL29661A (en) 1972-01-27
NL144944B (nl) 1975-02-17
DK118021B (da) 1970-06-29
US3494917A (en) 1970-02-10

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
EHJ Ceased/non-payment of the annual fee