DE1692515C3 - Sulfachinoxalin enthaltende Zubereitungen - Google Patents
Sulfachinoxalin enthaltende ZubereitungenInfo
- Publication number
- DE1692515C3 DE1692515C3 DE19661692515 DE1692515A DE1692515C3 DE 1692515 C3 DE1692515 C3 DE 1692515C3 DE 19661692515 DE19661692515 DE 19661692515 DE 1692515 A DE1692515 A DE 1692515A DE 1692515 C3 DE1692515 C3 DE 1692515C3
- Authority
- DE
- Germany
- Prior art keywords
- diaveridin
- water
- sulfachinoxaline
- solution
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims description 11
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 claims description 48
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 40
- 239000000243 solution Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 10
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims description 9
- NHZLNPMOSADWGC-UHFFFAOYSA-N 4-amino-N-(2-quinoxalinyl)benzenesulfonamide Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CN=C(C=CC=C2)C2=N1 NHZLNPMOSADWGC-UHFFFAOYSA-N 0.000 claims description 7
- 239000012895 dilution Substances 0.000 claims description 7
- 238000010790 dilution Methods 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 208000003495 Coccidiosis Diseases 0.000 claims description 5
- 206010023076 Isosporiasis Diseases 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 4
- 239000003651 drinking water Substances 0.000 claims description 4
- 235000020188 drinking water Nutrition 0.000 claims description 4
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 235000014666 liquid concentrate Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- -1 2-quinoxalinevl Chemical class 0.000 claims description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 6
- 244000144977 poultry Species 0.000 claims 5
- 231100000331 toxic Toxicity 0.000 claims 3
- 230000002588 toxic effect Effects 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- NHOWDZOIZKMVAI-UHFFFAOYSA-N (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol Chemical compound C=1N=CN=CC=1C(C=1C(=CC=CC=1)Cl)(O)C1=CC=C(Cl)C=C1 NHOWDZOIZKMVAI-UHFFFAOYSA-N 0.000 claims 1
- VTBAWGQQXHUBOM-UHFFFAOYSA-N 12,14-dimethoxy-2-oxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4,6,8(16),11(15),12-hexaene-6,13-diol Chemical compound O1CC(C2=3)=CC(O)=CC=3CCC3=C2C1=C(OC)C(O)=C3OC VTBAWGQQXHUBOM-UHFFFAOYSA-N 0.000 claims 1
- 239000001828 Gelatine Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000011717 all-trans-retinol Substances 0.000 claims 1
- 239000012526 feed medium Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- STAJLSYINUVEDD-UHFFFAOYSA-N hydrogen sulfate;quinoxalin-1-ium Chemical compound OS(O)(=O)=O.N1=CC=NC2=CC=CC=C21 STAJLSYINUVEDD-UHFFFAOYSA-N 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 230000009965 odorless effect Effects 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000009967 tasteless effect Effects 0.000 claims 1
- 238000011287 therapeutic dose Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 235000008504 concentrate Nutrition 0.000 description 20
- 239000012141 concentrate Substances 0.000 description 20
- 229950000246 diaveridine Drugs 0.000 description 17
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 239000002585 base Substances 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 4
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 4
- 235000019445 benzyl alcohol Nutrition 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 2
- 229940043276 diisopropanolamine Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- DPBLXKKOBLCELK-UHFFFAOYSA-N pentan-1-amine Chemical compound CCCCCN DPBLXKKOBLCELK-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 240000003550 Eusideroxylon zwageri Species 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- APVPOHHVBBYQAV-UHFFFAOYSA-N n-(4-aminophenyl)sulfonyloctadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 APVPOHHVBBYQAV-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB936265A GB1108112A (en) | 1965-03-04 | 1965-03-04 | Compositions containing sulphaquinoxaline and diaveridine for use in veterinary medicine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1692515A1 DE1692515A1 (de) | 1971-08-05 |
| DE1692515B2 DE1692515B2 (de) | 1973-10-25 |
| DE1692515C3 true DE1692515C3 (de) | 1974-06-06 |
Family
ID=9870478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19661692515 Expired DE1692515C3 (de) | 1965-03-04 | 1966-03-02 | Sulfachinoxalin enthaltende Zubereitungen |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT271082B (enExample) |
| BE (1) | BE677210A (enExample) |
| CH (1) | CH481113A (enExample) |
| CY (1) | CY601A (enExample) |
| DE (1) | DE1692515C3 (enExample) |
| DK (1) | DK116839B (enExample) |
| ES (1) | ES323769A1 (enExample) |
| FI (1) | FI45620C (enExample) |
| GB (1) | GB1108112A (enExample) |
| IL (1) | IL25266A (enExample) |
| IT (1) | IT1040502B (enExample) |
| LU (1) | LU50574A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1596044A (en) * | 1977-04-14 | 1981-08-19 | Wellcome Found | Veterinary compositions |
| CN103070907B (zh) * | 2012-12-28 | 2014-11-12 | 漳州师范学院 | 一种抗家禽球虫病药及其制备方法 |
-
1965
- 1965-03-04 GB GB936265A patent/GB1108112A/en not_active Expired
-
1966
- 1966-02-28 IL IL2526666A patent/IL25266A/xx unknown
- 1966-03-01 CH CH291366A patent/CH481113A/de not_active IP Right Cessation
- 1966-03-01 BE BE677210D patent/BE677210A/xx not_active IP Right Cessation
- 1966-03-02 DE DE19661692515 patent/DE1692515C3/de not_active Expired
- 1966-03-03 DK DK112666A patent/DK116839B/da unknown
- 1966-03-03 ES ES0323769A patent/ES323769A1/es not_active Expired
- 1966-03-03 IT IT479666A patent/IT1040502B/it active
- 1966-03-04 FI FI54766A patent/FI45620C/fi active
- 1966-03-04 LU LU50574A patent/LU50574A1/xx unknown
- 1966-03-04 AT AT203566A patent/AT271082B/de active
-
1971
- 1971-07-21 CY CY60171A patent/CY601A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT271082B (de) | 1969-05-27 |
| DE1692515B2 (de) | 1973-10-25 |
| DK116839B (da) | 1970-02-16 |
| IT1040502B (it) | 1979-12-20 |
| CH481113A (de) | 1969-11-15 |
| GB1108112A (en) | 1968-04-03 |
| LU50574A1 (enExample) | 1966-09-06 |
| BE677210A (enExample) | 1966-09-01 |
| IL25266A (en) | 1969-11-30 |
| FI45620C (fi) | 1972-08-10 |
| FI45620B (enExample) | 1972-05-02 |
| DE1692515A1 (de) | 1971-08-05 |
| CY601A (en) | 1971-07-21 |
| ES323769A1 (es) | 1967-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 |