DE1620748C3 - 2-n-Hexyl-2-(hydroxymethyl)-1,3propandiolnicotinate und Verfahren zu ihrer Herstellung - Google Patents

2-n-Hexyl-2-(hydroxymethyl)-1,3propandiolnicotinate und Verfahren zu ihrer Herstellung

Info

Publication number
DE1620748C3
DE1620748C3 DE1620748A DE1620748A DE1620748C3 DE 1620748 C3 DE1620748 C3 DE 1620748C3 DE 1620748 A DE1620748 A DE 1620748A DE 1620748 A DE1620748 A DE 1620748A DE 1620748 C3 DE1620748 C3 DE 1620748C3
Authority
DE
Germany
Prior art keywords
hydroxymethyl
hexyl
propanediol
preparation
nicotinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1620748A
Other languages
German (de)
English (en)
Other versions
DE1620748B2 (de
DE1620748A1 (de
Inventor
Katsuo Arimura
Ryosuke Kobayashi
Michio Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Yoshitomi Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical Industries Ltd filed Critical Yoshitomi Pharmaceutical Industries Ltd
Publication of DE1620748A1 publication Critical patent/DE1620748A1/de
Publication of DE1620748B2 publication Critical patent/DE1620748B2/de
Application granted granted Critical
Publication of DE1620748C3 publication Critical patent/DE1620748C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1620748A 1964-11-18 1965-11-16 2-n-Hexyl-2-(hydroxymethyl)-1,3propandiolnicotinate und Verfahren zu ihrer Herstellung Expired DE1620748C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6517864 1964-11-18
JP6285965 1965-10-12

Publications (3)

Publication Number Publication Date
DE1620748A1 DE1620748A1 (de) 1970-05-14
DE1620748B2 DE1620748B2 (de) 1974-10-24
DE1620748C3 true DE1620748C3 (de) 1975-06-19

Family

ID=26403915

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1620748A Expired DE1620748C3 (de) 1964-11-18 1965-11-16 2-n-Hexyl-2-(hydroxymethyl)-1,3propandiolnicotinate und Verfahren zu ihrer Herstellung

Country Status (9)

Country Link
US (1) US3384642A (https=)
BE (1) BE672385A (https=)
CH (1) CH451143A (https=)
DE (1) DE1620748C3 (https=)
DK (1) DK112383B (https=)
FR (1) FR4854M (https=)
GB (1) GB1131498A (https=)
NL (1) NL6514807A (https=)
SE (1) SE310676B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479364A (en) * 1967-07-17 1969-11-18 Searle & Co Pyridinecarboxylic acid esters of benzenehexol
CA2495962A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863873A (en) * 1956-08-29 1958-12-09 Bofors Ab Esters of nicotinic acid
GB904780A (en) * 1958-05-28 1962-08-29 Exxon Research Engineering Co Manufacture of trimethylol alkanes

Also Published As

Publication number Publication date
NL6514807A (https=) 1966-05-20
US3384642A (en) 1968-05-21
DE1620748B2 (de) 1974-10-24
GB1131498A (en) 1968-10-23
BE672385A (https=) 1966-05-16
FR4854M (https=) 1967-02-20
DK112383B (da) 1968-12-09
CH451143A (de) 1968-05-15
DE1620748A1 (de) 1970-05-14
SE310676B (https=) 1969-05-12

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
E77 Valid patent as to the heymanns-index 1977
EHJ Ceased/non-payment of the annual fee