DE1618868C3 - Verfahren zur Herstellung von 17alpha Athinyl 17beta bydroxysteroiden - Google Patents

Verfahren zur Herstellung von 17alpha Athinyl 17beta bydroxysteroiden

Info

Publication number
DE1618868C3
DE1618868C3 DE1618868A DE1618868A DE1618868C3 DE 1618868 C3 DE1618868 C3 DE 1618868C3 DE 1618868 A DE1618868 A DE 1618868A DE 1618868 A DE1618868 A DE 1618868A DE 1618868 C3 DE1618868 C3 DE 1618868C3
Authority
DE
Germany
Prior art keywords
reaction
sulfoxide
alkoxide
alkali metal
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1618868A
Other languages
German (de)
English (en)
Other versions
DE1618868B2 (de
DE1618868A1 (de
Inventor
Robert Mexiko Ginsig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of DE1618868A1 publication Critical patent/DE1618868A1/de
Publication of DE1618868B2 publication Critical patent/DE1618868B2/de
Application granted granted Critical
Publication of DE1618868C3 publication Critical patent/DE1618868C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
DE1618868A 1966-04-07 1967-04-06 Verfahren zur Herstellung von 17alpha Athinyl 17beta bydroxysteroiden Expired DE1618868C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54081566A 1966-04-07 1966-04-07

Publications (3)

Publication Number Publication Date
DE1618868A1 DE1618868A1 (de) 1972-07-06
DE1618868B2 DE1618868B2 (de) 1973-03-08
DE1618868C3 true DE1618868C3 (de) 1973-10-11

Family

ID=24157045

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1618868A Expired DE1618868C3 (de) 1966-04-07 1967-04-06 Verfahren zur Herstellung von 17alpha Athinyl 17beta bydroxysteroiden

Country Status (7)

Country Link
US (1) US3470217A (https=)
CH (1) CH490358A (https=)
DE (1) DE1618868C3 (https=)
DK (1) DK122275B (https=)
GB (1) GB1176229A (https=)
NL (1) NL6704744A (https=)
SE (1) SE337588B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618456A (en) * 1984-03-20 1986-10-21 The Upjohn Company Ethynylation of 16-methyl-17-keto steroids
US4614621A (en) * 1984-04-20 1986-09-30 The Upjohn Company Ethynylation of 16-methylene-17-keto steroids
EP2794632B1 (en) 2011-12-23 2016-03-16 Crystal Pharma S.A.U Process for alkynylating 16-substituted-17-keto steroids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2806030A (en) * 1954-03-20 1957-09-10 Syntex Sa Cyclopentanophenanthrene derivatives and process for the preparation thereof
US2888471A (en) * 1955-03-25 1959-05-26 Syntex Sa Process for preparing 17alpha-ethinyl-delta1, 4-androstadiene-17 beta-ol-3-one
NL123455C (https=) * 1964-05-13

Also Published As

Publication number Publication date
SE337588B (https=) 1971-08-16
DK122275B (da) 1972-02-14
GB1176229A (en) 1970-01-01
NL6704744A (https=) 1967-10-09
DE1618868B2 (de) 1973-03-08
CH490358A (de) 1970-05-15
DE1618868A1 (de) 1972-07-06
US3470217A (en) 1969-09-30

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
E77 Valid patent as to the heymanns-index 1977