DE1618577B2 - Verfahren zur stabilisierung einer waessrigen loesung von ascorbinsaeure - Google Patents
Verfahren zur stabilisierung einer waessrigen loesung von ascorbinsaeureInfo
- Publication number
- DE1618577B2 DE1618577B2 DE19671618577 DE1618577A DE1618577B2 DE 1618577 B2 DE1618577 B2 DE 1618577B2 DE 19671618577 DE19671618577 DE 19671618577 DE 1618577 A DE1618577 A DE 1618577A DE 1618577 B2 DE1618577 B2 DE 1618577B2
- Authority
- DE
- Germany
- Prior art keywords
- ascorbic acid
- acid
- calcium
- aqueous
- ascorbic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims description 93
- 229960005070 ascorbic acid Drugs 0.000 title claims description 46
- 235000010323 ascorbic acid Nutrition 0.000 title claims description 46
- 239000011668 ascorbic acid Substances 0.000 title claims description 46
- 238000000034 method Methods 0.000 title claims description 12
- 230000000087 stabilizing effect Effects 0.000 title claims 6
- 239000000243 solution Substances 0.000 claims description 17
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 16
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 235000019766 L-Lysine Nutrition 0.000 claims description 8
- 239000004472 Lysine Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 6
- 230000003647 oxidation Effects 0.000 claims 6
- 238000007254 oxidation reaction Methods 0.000 claims 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 4
- 229910001424 calcium ion Inorganic materials 0.000 claims 4
- 229960003104 ornithine Drugs 0.000 claims 4
- 230000006641 stabilisation Effects 0.000 claims 4
- 238000011105 stabilization Methods 0.000 claims 4
- WHQOKFZWSDOTQP-UHFFFAOYSA-N 2,3-dihydroxypropyl 4-aminobenzoate Chemical compound NC1=CC=C(C(=O)OCC(O)CO)C=C1 WHQOKFZWSDOTQP-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N Alanine Chemical compound CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000001110 calcium chloride Substances 0.000 claims 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N serine Chemical compound OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N tryptophan Chemical compound C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 229930195722 L-methionine Natural products 0.000 claims 1
- 229930182821 L-proline Natural products 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 230000003064 anti-oxidating effect Effects 0.000 claims 1
- 229940076638 ascorbic acid and calcium Drugs 0.000 claims 1
- 229960005261 aspartic acid Drugs 0.000 claims 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims 1
- 235000013921 calcium diglutamate Nutrition 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 229960002079 calcium pantothenate Drugs 0.000 claims 1
- UMVAYAXXQSFULN-QHTZZOMLSA-L calcium;(2s)-2-aminopentanedioate;hydron Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CCC(O)=O.[O-]C(=O)[C@@H](N)CCC(O)=O UMVAYAXXQSFULN-QHTZZOMLSA-L 0.000 claims 1
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 238000010411 cooking Methods 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims 1
- 229950010030 dl-alanine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960002885 histidine Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- 235000013923 monosodium glutamate Nutrition 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 claims 1
- 229960002429 proline Drugs 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- 229940073490 sodium glutamate Drugs 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Meat, Egg Or Seafood Products (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP738966 | 1966-02-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1618577A1 DE1618577A1 (de) | 1972-02-24 |
| DE1618577B2 true DE1618577B2 (de) | 1973-02-08 |
| DE1618577C3 DE1618577C3 (en, 2012) | 1973-09-13 |
Family
ID=11664555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19671618577 Granted DE1618577B2 (de) | 1966-02-10 | 1967-02-10 | Verfahren zur stabilisierung einer waessrigen loesung von ascorbinsaeure |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE693865A (en, 2012) |
| DE (1) | DE1618577B2 (en, 2012) |
| FR (1) | FR1510731A (en, 2012) |
| GB (1) | GB1125675A (en, 2012) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2521429B1 (fr) * | 1982-02-15 | 1988-10-28 | Mayoly Spindler Laboratoires | Nouvelles compositions a effet antiasthenique puissant a base de sels doubles de l'acide ascorbique et d'un diacide amine |
| HU194734B (en) * | 1985-07-11 | 1988-03-28 | Jozsef Bara | Process for production of medical and applicable for human consumption products suitable for treatment and/or prevention of diseases caused by free-radical reactions |
| AT393221B (de) * | 1988-02-03 | 1991-09-10 | Leopold Pharma Gmbh | Mittel mit zerstoerender wirkung auf maligne tumore, verfahren zu dessen herstellung und praeparation zur anwendung in der therapie von krebskranken |
| US6013632A (en) * | 1997-01-13 | 2000-01-11 | Emory University | Compounds and their combinations for the treatment of influenza infection |
| CN100346782C (zh) * | 2004-05-21 | 2007-11-07 | 北京京卫信康医药科技发展有限公司 | 一种含氨基酸的维生素c组合物 |
-
1967
- 1967-01-31 GB GB468867A patent/GB1125675A/en not_active Expired
- 1967-02-09 FR FR94383A patent/FR1510731A/fr not_active Expired
- 1967-02-09 BE BE693865D patent/BE693865A/xx unknown
- 1967-02-10 DE DE19671618577 patent/DE1618577B2/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE1618577C3 (en, 2012) | 1973-09-13 |
| DE1618577A1 (de) | 1972-02-24 |
| FR1510731A (fr) | 1968-01-19 |
| BE693865A (en, 2012) | 1967-07-17 |
| GB1125675A (en) | 1968-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2405215B2 (de) | Stabilisierte konzentrierte wäßrige Wasserstoffperoxidlösungen | |
| DD246245A5 (de) | Herbizide zusammensetzung | |
| DE1618577B2 (de) | Verfahren zur stabilisierung einer waessrigen loesung von ascorbinsaeure | |
| DE2227639A1 (de) | Photographische farbentwicklermischung | |
| DE3830616A1 (de) | Prophylaktikum fuer fische | |
| Busse et al. | Kinetische Untersuchungen der protolytischen Reaktionen von Aminosäuren und der komplementären Basen Adenin und Uracil | |
| DE943250C (de) | Verfahren zum Stabilisieren von antibiotisch wirksamen Inhaltsstoffen von Allium sativum | |
| DE859201C (de) | Zahnpaste | |
| EP0014957B1 (de) | Verfahren zur Trennung von Technetium-99m von Molybdän-99 | |
| DE2800538A1 (de) | Technetium-99m-markiertes diagnostikum zur untersuchung des res | |
| DE862252C (de) | Konservierung von Gruenfutter | |
| DE974991C (de) | Verfahren zur Herstellung von Zitronensaeure durch submerse Schimmelpilzgaerung | |
| DE743662C (de) | Verfahren zur Verbesserung der Wasserloeslichkeit von Estern der p- oder m-Oxybenzoesaeure | |
| DE2163062C3 (de) | Mittel zum Frischhalten von Schnittblumen | |
| DE895121C (de) | Verfahren zur Behandlung von carbonathaltigem Wasser | |
| DE495049C (de) | Insektenvertilgungsmittel | |
| AT217486B (de) | Herbicide Stoffe enthaltende Düngemittel | |
| DE1567631C (de) | Stabihsierungsverfahren fur wässrige Jod und/oder Jodverbindungen enthaltende Losungen | |
| DE344708C (en, 2012) | ||
| DE820837C (de) | Verfahren zum Einpoekeln von Fleisch | |
| Grüner et al. | Über die Bestimmung von Betainen als Phenylborate | |
| CH202460A (de) | Verfahren zur Herstellung eines Insulinpräparates. | |
| DE1467851A1 (de) | Verfahren zur Herstellung einer stabilen waessrigen Hydroxo-Cobalamin-Loesung | |
| DE1012031B (de) | Verfahren zum Stabilisieren von Loesungen von Ascorbinsaeure und Calciumsalzen, vorzugsweise Calciumglukonat | |
| DE1125576B (de) | Tritiumhaltige Leuchtpigmente und Verfahren zu ihrer Herstellung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |