DE1617466B2 - - Google Patents
Info
- Publication number
- DE1617466B2 DE1617466B2 DE1617466A DE1617466A DE1617466B2 DE 1617466 B2 DE1617466 B2 DE 1617466B2 DE 1617466 A DE1617466 A DE 1617466A DE 1617466 A DE1617466 A DE 1617466A DE 1617466 B2 DE1617466 B2 DE 1617466B2
- Authority
- DE
- Germany
- Prior art keywords
- moenomycin
- components
- water
- silica gel
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PERZMHJGZKHNGU-JGYWJTCASA-N bambermycin Chemical compound O([C@H]1[C@H](NC(C)=O)[C@@H](O)[C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1NC(C)=O)O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@H](O1)C(=O)NC=1C(CCC=1O)=O)O)C)[C@H]1[C@@H](OP(O)(=O)OC[C@@H](OC\C=C(/C)CC\C=C\C(C)(C)CCC(=C)C\C=C(/C)CCC=C(C)C)C(O)=O)O[C@H](C(O)=O)[C@@](C)(O)[C@@H]1OC(N)=O PERZMHJGZKHNGU-JGYWJTCASA-N 0.000 claims description 77
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 75
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 29
- 239000000741 silica gel Substances 0.000 claims description 27
- 229910002027 silica gel Inorganic materials 0.000 claims description 27
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 22
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 22
- 239000001103 potassium chloride Substances 0.000 claims description 11
- 235000011164 potassium chloride Nutrition 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 7
- 150000001450 anions Chemical class 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 239000003480 eluent Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 229960000583 acetic acid Drugs 0.000 description 6
- 238000010828 elution Methods 0.000 description 6
- 239000012362 glacial acetic acid Substances 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- 238000000921 elemental analysis Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 238000002329 infrared spectrum Methods 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 5
- 238000002211 ultraviolet spectrum Methods 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- XTHPWXDJESJLNJ-UHFFFAOYSA-N chlorosulfonic acid Substances OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 238000004255 ion exchange chromatography Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 159000000001 potassium salts Chemical class 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- DAMJCWMGELCIMI-UHFFFAOYSA-N benzyl n-(2-oxopyrrolidin-3-yl)carbamate Chemical compound C=1C=CC=CC=1COC(=O)NC1CCNC1=O DAMJCWMGELCIMI-UHFFFAOYSA-N 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 238000004816 paper chromatography Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- NTBYIQWZAVDRHA-JGWLITMVSA-N (2r,3r,4r,5r)-2-amino-3,4,5-trihydroxyhexanal Chemical compound C[C@@H](O)[C@@H](O)[C@H](O)[C@@H](N)C=O NTBYIQWZAVDRHA-JGWLITMVSA-N 0.000 description 1
- ZYECOAILUNWEAL-NUDFZHEQSA-N (4z)-4-[[2-methoxy-5-(phenylcarbamoyl)phenyl]hydrazinylidene]-n-(3-nitrophenyl)-3-oxonaphthalene-2-carboxamide Chemical compound COC1=CC=C(C(=O)NC=2C=CC=CC=2)C=C1N\N=C(C1=CC=CC=C1C=1)/C(=O)C=1C(=O)NC1=CC=CC([N+]([O-])=O)=C1 ZYECOAILUNWEAL-NUDFZHEQSA-N 0.000 description 1
- QGPZXNSBZMHHSR-UHFFFAOYSA-N 2-carboxybenzoate;phenylazanium Chemical compound NC1=CC=CC=C1.OC(=O)C1=CC=CC=C1C(O)=O QGPZXNSBZMHHSR-UHFFFAOYSA-N 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- TVTGZVYLUHVBAJ-IVMDWMLBSA-N D-quinovosamine Chemical compound C[C@H]1OC(O)[C@H](N)[C@@H](O)[C@@H]1O TVTGZVYLUHVBAJ-IVMDWMLBSA-N 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241001646618 Streptomyces ederensis Species 0.000 description 1
- 241000971019 Streptomyces geysiriensis Species 0.000 description 1
- 241000946809 Streptomyces prasinus Species 0.000 description 1
- 241000948169 Streptomyces viridosporus Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- -1 aliphatic alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- JMJRNNLOJLYQLM-UHFFFAOYSA-N azane;propan-1-ol Chemical compound N.CCCO JMJRNNLOJLYQLM-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 244000000059 gram-positive pathogen Species 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19511617466 DE1617466A1 (de) | 1951-01-28 | 1951-01-28 | Verfahren zur Trennung von Moenomyein-Komponenten |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19511617466 DE1617466A1 (de) | 1951-01-28 | 1951-01-28 | Verfahren zur Trennung von Moenomyein-Komponenten |
| DEF0050345 | 1966-10-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1617466A1 DE1617466A1 (de) | 1971-04-08 |
| DE1617466B2 true DE1617466B2 (ref) | 1974-04-18 |
| DE1617466C3 DE1617466C3 (ref) | 1974-11-14 |
Family
ID=7103726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19511617466 Granted DE1617466A1 (de) | 1951-01-28 | 1951-01-28 | Verfahren zur Trennung von Moenomyein-Komponenten |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT274237B (ref) |
| BE (1) | BE704567A (ref) |
| CA (1) | CA961485A (ref) |
| CH (1) | CH489604A (ref) |
| DE (1) | DE1617466A1 (ref) |
| DK (4) | DK120771B (ref) |
| ES (1) | ES345490A1 (ref) |
| GB (1) | GB1196648A (ref) |
| IT (1) | IT1047864B (ref) |
| NL (1) | NL6713089A (ref) |
| SE (2) | SE347656B (ref) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0872556A3 (de) * | 1997-04-17 | 2000-06-14 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von Moenomycin A |
-
1951
- 1951-01-28 DE DE19511617466 patent/DE1617466A1/de active Granted
-
1967
- 1967-09-26 NL NL6713089A patent/NL6713089A/xx unknown
- 1967-09-27 ES ES345490A patent/ES345490A1/es not_active Expired
- 1967-09-28 SE SE13316/67A patent/SE347656B/xx unknown
- 1967-09-29 DK DK485867AA patent/DK120771B/da unknown
- 1967-09-29 CH CH1360867A patent/CH489604A/de not_active IP Right Cessation
- 1967-09-29 AT AT885167A patent/AT274237B/de active
- 1967-09-30 CA CA001,390A patent/CA961485A/en not_active Expired
- 1967-09-30 IT IT21141/67A patent/IT1047864B/it active
- 1967-10-02 BE BE704567D patent/BE704567A/xx unknown
- 1967-10-02 GB GB44732/67A patent/GB1196648A/en not_active Expired
-
1969
- 1969-03-31 DK DK177569AA patent/DK121569B/da unknown
-
1970
- 1970-02-03 SE SE01337/70A patent/SE347657B/xx unknown
- 1970-02-27 DK DK100470AA patent/DK121528B/da unknown
- 1970-05-08 DK DK236070AA patent/DK121812B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES345490A1 (es) | 1969-01-01 |
| GB1196648A (en) | 1970-07-01 |
| DK121569B (da) | 1971-11-01 |
| BE704567A (ref) | 1968-04-02 |
| CH489604A (de) | 1970-04-30 |
| AT274237B (de) | 1969-09-10 |
| DK121812B (da) | 1971-12-06 |
| DK121528B (da) | 1971-10-25 |
| CA961485A (en) | 1975-01-21 |
| SE347657B (ref) | 1972-08-14 |
| SE347656B (ref) | 1972-08-14 |
| NL6713089A (ref) | 1968-04-02 |
| DE1617466C3 (ref) | 1974-11-14 |
| IT1047864B (it) | 1980-10-20 |
| DE1617466A1 (de) | 1971-04-08 |
| DK120771B (da) | 1971-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2047368A1 (de) | Verfahren zur Herstellung von 9 (beta D Arabinofuranosyl) adenin 5 phos phat | |
| Argoudelis et al. | Paulomycins A and B isolation and characterization | |
| DE1617466C3 (ref) | ||
| Bui-Dang-Ha et al. | Isolation of zeatin riboside from the chicory root | |
| US3660569A (en) | Process for separating moenomycin | |
| Tatsuoka et al. | Studies on antibiotics. XVI. Isolation and identification of dihydrostreptomycin produced by a new streptomyces, Streptomyces humidus nov. sp. | |
| EP0872556A2 (de) | Verfahren zur Herstellung von Moenomycin A | |
| DE3012014C2 (de) | Istamycine, Verfahren zu deren Herstellung sowie Verwendung derselben als antibakterielle Mittel | |
| Martin et al. | GLYCOCINNAMOYLSPERMIDINES, A NEW CLASS OF ANTIBIOTICS II. ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF LL-BM123β, γ 1, AND γ 2 | |
| DE2408227A1 (de) | Neue antibiotika und verfahren zu ihrer gewinnung | |
| CH620243A5 (ref) | ||
| DE2833689C2 (ref) | ||
| Schacht et al. | MOENOMYCIN. VII ISOLATION AND PROPERTIES OF FURTHER COMPONENTS OF THE ANTIBIOTIC MOENOMYCIN | |
| DE2450411C3 (ref) | ||
| DE3329218C2 (de) | Verfahren zur Reinigung von S-Adenosyl-L-methionin | |
| DE1118402B (de) | Verfahren zur Reinigung von Ferrimycin und zum Trennen in seine Komponenten | |
| DE2737944C2 (de) | Verfahren zur Herstellung von Maltopentaose und Maltohexaose | |
| DE890265C (de) | Verfahren zur Herstellung eines neuen anti-perniziosa-anaemischen Faktors | |
| DE1770740C3 (de) | Neue Pyrimidinnucleoside (Polyoxine ], K und L) und Verfahren zu ihrer Herstellung | |
| US3093550A (en) | Process for the manufacture of ferrimycin | |
| DE1795154C3 (de) | Verfahren zur Herstellung eines neuen, Tuberactin genannten antibiotischen Wirkstoffes | |
| DE946254C (de) | Verfahren zur Herstellung von Abbauprodukten des Vitamin B-Faktors III | |
| DE1077380B (de) | Herstellung des Antibiotikums Lemacidin | |
| DE2326781C3 (de) | Antibioticum XK-62-2, dessen Sulfat und Verfahren zur Herstellung desselben | |
| DE1017324B (de) | Verfahren zur Biosynthese von Vitaminen der B-Gruppe (Cobalamin-Analogen) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |