DE1545635A1 - Verfahren zur Herstellung von Adenosin-Derivaten - Google Patents
Verfahren zur Herstellung von Adenosin-DerivatenInfo
- Publication number
- DE1545635A1 DE1545635A1 DE19651545635 DE1545635A DE1545635A1 DE 1545635 A1 DE1545635 A1 DE 1545635A1 DE 19651545635 DE19651545635 DE 19651545635 DE 1545635 A DE1545635 A DE 1545635A DE 1545635 A1 DE1545635 A1 DE 1545635A1
- Authority
- DE
- Germany
- Prior art keywords
- adenosine
- preparation
- adenosine derivatives
- general formula
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 8
- 150000003835 adenosine derivatives Chemical class 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title claims description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 10
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 7
- 229960005305 adenosine Drugs 0.000 description 7
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 239000002026 chloroform extract Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- VANNPISTIUFMLH-UHFFFAOYSA-N glutaric anhydride Chemical compound O=C1CCCC(=O)O1 VANNPISTIUFMLH-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 2
- 229940014800 succinic anhydride Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 101100348097 Mus musculus Ncor2 gene Proteins 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000002327 cardiovascular agent Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0084139 | 1965-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1545635A1 true DE1545635A1 (de) | 1969-08-07 |
Family
ID=6982298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19651545635 Pending DE1545635A1 (de) | 1965-10-16 | 1965-10-16 | Verfahren zur Herstellung von Adenosin-Derivaten |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT263220B (enrdf_load_stackoverflow) |
| CH (1) | CH473145A (enrdf_load_stackoverflow) |
| DE (1) | DE1545635A1 (enrdf_load_stackoverflow) |
| FI (1) | FI46384C (enrdf_load_stackoverflow) |
| FR (1) | FR1502939A (enrdf_load_stackoverflow) |
| GB (1) | GB1090358A (enrdf_load_stackoverflow) |
| NL (1) | NL6614469A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3028272A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung |
| DE3028288A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung |
-
1965
- 1965-10-16 DE DE19651545635 patent/DE1545635A1/de active Pending
-
1966
- 1966-10-12 GB GB45573/66A patent/GB1090358A/en not_active Expired
- 1966-10-14 FI FI662709A patent/FI46384C/fi active
- 1966-10-14 FR FR80009A patent/FR1502939A/fr not_active Expired
- 1966-10-14 NL NL6614469A patent/NL6614469A/xx unknown
- 1966-10-14 AT AT962066A patent/AT263220B/de active
-
1967
- 1967-10-13 CH CH1482766A patent/CH473145A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL6614469A (enrdf_load_stackoverflow) | 1967-04-17 |
| CH473145A (de) | 1969-05-31 |
| GB1090358A (en) | 1967-11-08 |
| FI46384C (fi) | 1973-03-12 |
| AT263220B (de) | 1968-07-10 |
| FR1502939A (fr) | 1967-11-24 |
| FI46384B (enrdf_load_stackoverflow) | 1972-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE1670849A1 (de) | Verfahren zur Herstellung von 8-Acylaminotetrahydroisochinolinen | |
| DE1962757C3 (de) | Evomonosid-Derivate, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel | |
| DE1545635A1 (de) | Verfahren zur Herstellung von Adenosin-Derivaten | |
| DE1795509B2 (de) | Verfahren zur herstellung von 3-hydroxy-7-chlor-1,2-dihydro-3h-1,4-benzo- diazepin-2-on-derivaten | |
| DE1545645A1 (de) | Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten | |
| DE1126882B (de) | Verfahren zur Herstellung von 1,2,4-Triazolonen-(5) | |
| DE2238923A1 (de) | Acylierte n(6)-aralkyl-adenosinderivate und verfahren zur herstellung derselben | |
| DE2661027C2 (enrdf_load_stackoverflow) | ||
| DE1907804C3 (de) | 4-Chlor-1alpha,2alpha;6alpha,7alphadimethylen-3-keto-4-pregnene, Verfahren zu deren Herstellung sowie diese enthaltendes Mittel | |
| DE952899C (de) | Verfahren zur Herstellung von Derivaten des 2-Methyl-5-oxy-8-methoxy-6, 7-furanochromons | |
| DE3613199A1 (de) | Verfahren zur herstellung von eburnamenin-derivaten, neue eburnamenine und pharmazeutische zusammensetzung | |
| DE930753C (de) | Verfahren zur Herstellung von 12-Bromsteroidketonaddukten | |
| DE1058519B (de) | Verfahren zur Herstellung von Pyrazolo-[3, 4-d]-v-triazinen | |
| DE1131693B (de) | Verfahren zur Herstellung von 18ª-Acetoxy-17ª-methoxy-16ª-methoxycarbonyl-2, 3-seco-3-oxo-20ª-yohimbanen | |
| AT361933B (de) | Verfahren zur herstellung von neuen 5,11- -dihydro-6h-pyrido(2,3-b)(1,4)- benzodiazepin-6 -on-derivaten und ihren salzen | |
| DE1011888B (de) | Verfahren zur Herstellung von Theophyllinderivaten | |
| DE1902595A1 (de) | Neue Chinolin-Derivate und Verfahren zu ihrer Herstellung | |
| DE1957246A1 (de) | Verfahren zur Herstellung von 3beta-Hydroxy-5beta-cardenoliden | |
| DE2063406B2 (de) | Acylderivate des proscillaridin a, verfahren zu deren herstellung und diese enthaltende praeparate | |
| DE1231707B (de) | Verfahren zur Herstellung von Linol- und/oder Linolensaeure-Magnesium-Xanthinsalzen | |
| DE1695909B2 (de) | Verfahren zur herstellung von 1-(5- nitro-2-thiazolyl)-2-oxo-imidazolidinen | |
| DE1568499A1 (de) | Verfahren zur Herstellung von ungesaettigten Lactonen der Steroidreihe | |
| DE1090207B (de) | Verfahren zur Herstellung wasserloeslicher Corticosteroidderivate | |
| DE1169950B (de) | Verfahren zur Herstellung von 2, 3-Dehydroemetinderivaten | |
| DE1220427B (de) | Verfahren zur Herstellung von 1, 2-Bis-(p-trifluormethylphenyl)-3, 5-dioxo-pyrazolidinen |