DE151036C - - Google Patents
Info
- Publication number
- DE151036C DE151036C DENDAT151036D DE151036DA DE151036C DE 151036 C DE151036 C DE 151036C DE NDAT151036 D DENDAT151036 D DE NDAT151036D DE 151036D A DE151036D A DE 151036DA DE 151036 C DE151036 C DE 151036C
- Authority
- DE
- Germany
- Prior art keywords
- arbutin
- monobenzoylarbutine
- parts
- benzoyl chloride
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N ARBUTIN Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 14
- 229960000271 Arbutin Drugs 0.000 claims description 8
- PASDCCFISLVPSO-UHFFFAOYSA-N Benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 239000012295 chemical reaction liquid Substances 0.000 claims description 2
- 230000001264 neutralization Effects 0.000 claims description 2
- 230000005591 charge neutralization Effects 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 210000004369 Blood Anatomy 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000006480 benzoylation reaction Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L Barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 1
- 210000004211 Gastric Acid Anatomy 0.000 description 1
- 210000002784 Stomach Anatomy 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000010428 baryte Substances 0.000 description 1
- 229910052601 baryte Inorganic materials 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE151036C true DE151036C (fr) |
Family
ID=417889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT151036D Active DE151036C (fr) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE151036C (fr) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10729664B2 (en) | 2009-07-10 | 2020-08-04 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10842798B1 (en) | 2019-11-06 | 2020-11-24 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10927096B2 (en) | 2019-03-11 | 2021-02-23 | Nocion Therapeutics, Inc. | Ester substituted ion channel blockers and methods for use |
| US10934263B2 (en) | 2019-03-11 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11021443B2 (en) | 2015-08-03 | 2021-06-01 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
| US11332446B2 (en) | 2020-03-11 | 2022-05-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11377422B2 (en) | 2019-03-11 | 2022-07-05 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
-
0
- DE DENDAT151036D patent/DE151036C/de active Active
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10729664B2 (en) | 2009-07-10 | 2020-08-04 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| US11021443B2 (en) | 2015-08-03 | 2021-06-01 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
| US10934263B2 (en) | 2019-03-11 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10927096B2 (en) | 2019-03-11 | 2021-02-23 | Nocion Therapeutics, Inc. | Ester substituted ion channel blockers and methods for use |
| US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11377422B2 (en) | 2019-03-11 | 2022-07-05 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11512058B2 (en) | 2019-03-11 | 2022-11-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11603355B2 (en) | 2019-03-11 | 2023-03-14 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11643404B2 (en) | 2019-03-11 | 2023-05-09 | Nocion Therapeutics, Inc. | Ester substituted ion channel blockers and methods for use |
| US10842798B1 (en) | 2019-11-06 | 2020-11-24 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11696912B2 (en) | 2019-11-06 | 2023-07-11 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11332446B2 (en) | 2020-03-11 | 2022-05-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE151036C (fr) | ||
| DE938502C (de) | Verfahren zur Herstellung einer kolloidalen Eisenzubereitung | |
| DE69908181T2 (de) | Methode zur herstellung eines antitumormittels und dadurch erhaltenes tumormittel | |
| DE403054C (de) | Verfahren zur Darstellung von Wismutkakodylat | |
| DE117767C (fr) | ||
| EP0222198B1 (fr) | Produits contenant de l'amitriptylinoxyde pour l'administration parentérale dans la thérapie de la dépression | |
| DE2435222C2 (de) | Verfahren zur Herstellung von N-(2-Diethylamino)-ethyl-2-methoxy-5-methylsulfonylbenzamid | |
| DE504183C (de) | Verfahren zur Darstellung therapeutisch wertvoller, steriler und haltbarer, zu Injektionen geeigneter Loesungen von p-dialkylaminoarylphosphinigsauren Salzen | |
| DE532766C (de) | Verfahren zur Darstellung von Jodmethansulfonsaeure | |
| AT117475B (de) | Verfahren zur Darstellung von Substitutionsprodukten des ß-Jodpyridins. | |
| DE875359C (de) | Verfahren zur Darstellung von Pantothensaeure | |
| DE62176C (de) | Verfahren zur Darstellung von Zimmtsäure-Guajacolester | |
| DE194533C (fr) | ||
| DE211212C (fr) | ||
| DE423821C (de) | Verfahren zur Herstellung nicht giftiger, stark bakterizider Cerloesungen | |
| DE88950C (fr) | ||
| DE479715C (de) | Verfahren zur Gewinnung von Theobromin aus theobrominhaltigen Naturprodukten | |
| DE106496C (fr) | ||
| DE338427C (de) | Verfahren zur Herstellung von Additionsprodukten des Hexamethylentetramins | |
| DE331887C (de) | Verfahren zur Herstellung Ioeslicher, entfaerbter, geruch- und geschmackloser Eiweissstoffe aus Blut | |
| DE253839C (fr) | ||
| DE469233C (de) | Verfahren zur Darstellung haltbarer Jodoele | |
| DE1223380B (de) | Verfahren zur Herstellung von wasserloeslichen Phosphonitrilverbindungen | |
| DE184693C (fr) | ||
| DE357752C (de) | Verfahren zur Darstellung von N-Aminoacetylverbindungen der 4-Amino-1-phenyl-2íñ3-dialkyl-5-pyrazolone |