DE1467881A1 - Herstellung und Verwendung von Antibiotica - Google Patents
Herstellung und Verwendung von AntibioticaInfo
- Publication number
- DE1467881A1 DE1467881A1 DE19651467881 DE1467881A DE1467881A1 DE 1467881 A1 DE1467881 A1 DE 1467881A1 DE 19651467881 DE19651467881 DE 19651467881 DE 1467881 A DE1467881 A DE 1467881A DE 1467881 A1 DE1467881 A1 DE 1467881A1
- Authority
- DE
- Germany
- Prior art keywords
- anthelvencin
- antibiotic
- acid
- aqueous
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 16
- 239000003242 anti bacterial agent Substances 0.000 title description 4
- 229940088710 antibiotic agent Drugs 0.000 title description 4
- 229930191069 Anthelvencin Natural products 0.000 claims description 66
- 150000003839 salts Chemical class 0.000 claims description 42
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 25
- 235000015165 citric acid Nutrition 0.000 claims description 21
- 238000012360 testing method Methods 0.000 claims description 20
- ZKNZAWGJQIYHNE-LBPRGKRZSA-N 4-[[4-[[(2s)-5-amino-3,4-dihydro-2h-pyrrole-2-carbonyl]amino]-1h-pyrrole-2-carbonyl]amino]-n-(3-amino-3-iminopropyl)-1-methylpyrrole-2-carboxamide Chemical compound C1=C(C(=O)NCCC(N)=N)N(C)C=C1NC(=O)C1=CC(NC(=O)[C@H]2N=C(N)CC2)=CN1 ZKNZAWGJQIYHNE-LBPRGKRZSA-N 0.000 claims description 19
- ZKNZAWGJQIYHNE-UHFFFAOYSA-N Anthelvencin A Natural products C1=C(C(=O)NCCC(N)=N)N(C)C=C1NC(=O)C1=CC(NC(=O)C2N=C(N)CC2)=CN1 ZKNZAWGJQIYHNE-UHFFFAOYSA-N 0.000 claims description 19
- 230000003115 biocidal effect Effects 0.000 claims description 19
- QLVFNFMPVONXSG-UHFFFAOYSA-N 4-[(5-amino-3,4-dihydro-2h-pyrrole-2-carbonyl)amino]-n-[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamide Chemical compound C1=C(C(=O)NCCC(N)=N)N(C)C=C1NC(=O)C1=CC(NC(=O)C2N=C(N)CC2)=CN1C QLVFNFMPVONXSG-UHFFFAOYSA-N 0.000 claims description 18
- 239000001963 growth medium Substances 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 16
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 241000531819 Streptomyces venezuelae Species 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
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- 239000004305 biphenyl Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000008272 agar Substances 0.000 description 8
- 229960001860 salicylate Drugs 0.000 description 8
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- 150000001875 compounds Chemical class 0.000 description 7
- 238000011081 inoculation Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
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- 241001465754 Metazoa Species 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
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- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- 229960004025 sodium salicylate Drugs 0.000 description 1
- YWPOLRBWRRKLMW-UHFFFAOYSA-M sodium;naphthalene-2-sulfonate Chemical compound [Na+].C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 YWPOLRBWRRKLMW-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/906—Streptomyces venezuelae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35140964A | 1964-03-12 | 1964-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1467881A1 true DE1467881A1 (de) | 1969-05-29 |
Family
ID=23380801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19651467881 Pending DE1467881A1 (de) | 1964-03-12 | 1965-03-12 | Herstellung und Verwendung von Antibiotica |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3467750A (en, 2012) |
| BE (1) | BE661051A (en, 2012) |
| BR (1) | BR6567802D0 (en, 2012) |
| DE (1) | DE1467881A1 (en, 2012) |
| DK (1) | DK117945B (en, 2012) |
| FR (1) | FR1599668A (en, 2012) |
| GB (1) | GB1092059A (en, 2012) |
| NL (1) | NL6503204A (en, 2012) |
| NO (1) | NO121391B (en, 2012) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089816A (en) * | 1957-10-29 | 1963-05-14 | Ciba Geigy Corp | Lemacidine and process for its manufacture |
-
1964
- 1964-03-12 US US351409A patent/US3467750A/en not_active Expired - Lifetime
-
1965
- 1965-03-12 FR FR1599668D patent/FR1599668A/fr not_active Expired
- 1965-03-12 BE BE661051A patent/BE661051A/xx unknown
- 1965-03-12 DE DE19651467881 patent/DE1467881A1/de active Pending
- 1965-03-12 DK DK126165AA patent/DK117945B/da unknown
- 1965-03-12 BR BR167802/65A patent/BR6567802D0/pt unknown
- 1965-03-12 NO NO157192A patent/NO121391B/no unknown
- 1965-03-12 GB GB10650/65A patent/GB1092059A/en not_active Expired
- 1965-03-12 NL NL6503204A patent/NL6503204A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3467750A (en) | 1969-09-16 |
| BE661051A (en, 2012) | 1965-09-13 |
| GB1092059A (en) | 1967-11-22 |
| BR6567802D0 (pt) | 1973-08-07 |
| FR1599668A (en, 2012) | 1970-07-20 |
| NO121391B (en, 2012) | 1971-02-22 |
| DK117945B (da) | 1970-06-22 |
| NL6503204A (en, 2012) | 1965-09-13 |
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