DE122008000031I1 - 8-Chlor-11-[1-[(5-methyl-3-pyridyl)-methyl]-4-piperidyliden]-6,11-dihydro-5H-benzol[5,6]cyclohepta[1,2-b]-pyridin - Google Patents

8-Chlor-11-[1-[(5-methyl-3-pyridyl)-methyl]-4-piperidyliden]-6,11-dihydro-5H-benzol[5,6]cyclohepta[1,2-b]-pyridin

Info

Publication number
DE122008000031I1
DE122008000031I1 DE122008000031C DE122008000031C DE122008000031I1 DE 122008000031 I1 DE122008000031 I1 DE 122008000031I1 DE 122008000031 C DE122008000031 C DE 122008000031C DE 122008000031 C DE122008000031 C DE 122008000031C DE 122008000031 I1 DE122008000031 I1 DE 122008000031I1
Authority
DE
Germany
Prior art keywords
methyl
cyclohepta
pyridyl
pyridine
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE122008000031C
Other languages
English (en)
Other versions
DE122008000031I2 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Publication of DE122008000031I1 publication Critical patent/DE122008000031I1/de
Publication of DE122008000031I2 publication Critical patent/DE122008000031I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DE122008000031C 1992-05-22 1993-05-19 8-Chlor-11-[1-[(5-methyl-3-pyridyl)-methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]-pyridin Active DE122008000031I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09201054A ES2042421B1 (es) 1992-05-22 1992-05-22 Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
DE69300255T DE69300255T2 (de) 1992-05-22 1993-05-19 8-Chlor-11-(1-(5-methyl-3-pyridyl)methyl-4-piperidyliden)-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)-pyridin.

Publications (2)

Publication Number Publication Date
DE122008000031I1 true DE122008000031I1 (de) 2008-10-02
DE122008000031I2 DE122008000031I2 (de) 2010-12-30

Family

ID=8277082

Family Applications (2)

Application Number Title Priority Date Filing Date
DE122008000031C Active DE122008000031I2 (de) 1992-05-22 1993-05-19 8-Chlor-11-[1-[(5-methyl-3-pyridyl)-methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]-pyridin
DE69300255T Expired - Lifetime DE69300255T2 (de) 1992-05-22 1993-05-19 8-Chlor-11-(1-(5-methyl-3-pyridyl)methyl-4-piperidyliden)-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)-pyridin.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69300255T Expired - Lifetime DE69300255T2 (de) 1992-05-22 1993-05-19 8-Chlor-11-(1-(5-methyl-3-pyridyl)methyl-4-piperidyliden)-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)-pyridin.

Country Status (13)

Country Link
US (2) US5407941A (de)
EP (1) EP0577957B1 (de)
JP (1) JP2730612B2 (de)
KR (1) KR0156518B1 (de)
AT (1) ATE124939T1 (de)
CA (1) CA2096318C (de)
DE (2) DE122008000031I2 (de)
DK (1) DK0577957T3 (de)
ES (2) ES2042421B1 (de)
HK (1) HK1006169A1 (de)
LU (1) LU91121I2 (de)
MX (1) MX9302958A (de)
NL (1) NL300384I2 (de)

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US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) * 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
FI941826A (fi) * 1993-04-21 1994-10-22 Takeda Chemical Industries Ltd Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
ES2087818B1 (es) * 1993-11-24 1997-03-16 Uriach & Cia Sa J 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) * 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
ES2120899B1 (es) * 1996-10-07 1999-06-16 Uriach & Cia Sa J Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11-(1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
ES2241133T3 (es) 1997-04-28 2005-10-16 Encysive Pharmaceuticals Inc. Sulfamidas para el tratamiento de los trastornos inducidos por la endotelina.
JP2001519428A (ja) * 1997-10-10 2001-10-23 シェーリング コーポレイション エチル４−（８−クロロ−５，６−ジヒドロ−１１Ｈ−ベンゾ［５，６］シクロヘプタ［１，２−ｂ］ピリジン−１１−イリデン）−１−ピペリデンカルボキシレート多形物
WO2001045668A2 (en) * 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
SK287105B6 (sk) * 1999-12-20 2009-12-07 Schering Corporation Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
AU2001284320A1 (en) * 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Process for the synthesis of n-(5-methylnicotinoyl)-4-hydroxypiperidine, a key intermediate of rupatadine
WO2004080461A2 (en) * 2003-03-12 2004-09-23 TEVA Gyógyszergyár Részvénytársaság Stable pharmaceutical compositions of desloratadine
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
US20090197907A1 (en) * 2005-04-01 2009-08-06 Hetero Drugs Limited Novel crystalline form of rupatadine free base
WO2006114676A2 (en) * 2005-04-27 2006-11-02 Cadila Pharmaceuticals Limited A process for the preparation of rupatadine
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
CN101497606B (zh) * 2008-01-29 2014-04-02 东莞达信生物技术有限公司 卢帕他定或其盐的制备方法
BR112012028919B1 (pt) * 2010-06-30 2021-11-09 J. Uriach Y Compañia S.A. Sal da rupatadina como um agente anti-histamínico
PT2402012E (pt) 2010-06-30 2013-02-25 Uriach Y Compania S A J Formulações líquidas de fumarato de rupatadina
CN103619839B (zh) * 2011-06-28 2016-06-01 福建省闽东力捷迅药业有限公司 抗-变态反应的苯并环庚并噻吩衍生物
CN102653535A (zh) * 2011-12-09 2012-09-05 东莞达信生物技术有限公司 卢帕他定游离碱及其制取方法
ES2572533T3 (es) 2013-07-09 2016-06-01 Cadila Pharmaceuticals Limited Un proceso mejorado para la preparación de fumarato de rupatadina
US10463656B2 (en) 2017-01-05 2019-11-05 Iowa State University Research Foundation, Inc. Methods and compositions for prevention of feedlot bovine respiratory disease
TWI825013B (zh) 2017-04-19 2023-12-11 日商帝國製藥股份有限公司 含有盧帕他定（ｒｕｐａｔａｄｉｎｅ）之貼附劑
CN109096251B (zh) * 2018-09-26 2020-11-03 合肥医工医药股份有限公司 具有组胺受体双重拮抗活性的化合物及用途
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Also Published As

Publication number Publication date
LU91121I2 (fr) 2005-01-03
DK0577957T3 (da) 1995-12-04
KR0156518B1 (ko) 1998-11-16
NL300384I1 (nl) 2009-06-02
DE122008000031I2 (de) 2010-12-30
KR930023359A (ko) 1993-12-18
US5407941A (en) 1995-04-18
CA2096318A1 (en) 1993-11-23
DE69300255T2 (de) 1996-01-04
ES2076817T3 (es) 1995-11-01
EP0577957B1 (de) 1995-07-12
CA2096318C (en) 1998-06-23
NL300384I2 (nl) 2009-08-03
DE69300255D1 (de) 1995-08-17
JPH0687856A (ja) 1994-03-29
ATE124939T1 (de) 1995-07-15
ES2042421B1 (es) 1994-08-01
JP2730612B2 (ja) 1998-03-25
EP0577957A1 (de) 1994-01-12
US5476856A (en) 1995-12-19
ES2042421A1 (es) 1993-12-01
HK1006169A1 (en) 1999-02-12
MX9302958A (es) 1993-11-01

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