ES2087818A1 - 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato. - Google Patents

8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.

Info

Publication number
ES2087818A1
ES2087818A1 ES09302460A ES9302460A ES2087818A1 ES 2087818 A1 ES2087818 A1 ES 2087818A1 ES 09302460 A ES09302460 A ES 09302460A ES 9302460 A ES9302460 A ES 9302460A ES 2087818 A1 ES2087818 A1 ES 2087818A1
Authority
ES
Spain
Prior art keywords
methyl
cycloheptal
piperidylidene
benzo
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09302460A
Other languages
English (en)
Other versions
ES2087818B1 (es
Inventor
Elena Carceller
Nuria Recasens
Carmen Almansa
Javier Bartroli
Manel Merlos
Marta Giral
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES09302460A priority Critical patent/ES2087818B1/es
Priority to NO944487A priority patent/NO305436B1/no
Publication of ES2087818A1 publication Critical patent/ES2087818A1/es
Application granted granted Critical
Publication of ES2087818B1 publication Critical patent/ES2087818B1/es
Anticipated expiration legal-status Critical
Priority to NO2014001C priority patent/NO2014001I2/no
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION DESCRIBE EL COMPUESTO 8-CLORO-11-[1-[(5-METIL-3-PIRIDIL)METIL]-4-PIPERIDILIDEN]-6,11-DIHIDRO-5H-BENZO[5,6] CICLOHEPTA[1,2-B]PIRIDINA FUMARATO, ASI COMO UN PROCEDIMIENTO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN. ESTE COMPUESTO POSEE ACTIVIDAD DUAL COMO ANTAGONISTA DEL PAF Y ANTIHISTAMINICO Y PRESENTA UNA ESTABILIDAD MEJORADA, LO CUAL LO HACE PARTICULARMENTE UTIL PARA LA PREPARACION DE MEDICAMENTOS.
ES09302460A 1993-11-24 1993-11-24 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato. Expired - Fee Related ES2087818B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES09302460A ES2087818B1 (es) 1993-11-24 1993-11-24 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.
NO944487A NO305436B1 (no) 1993-11-24 1994-11-23 8-klor-11-[1-[(5-metyl-3-pyridyl)metyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]syklohepta[1,2-b]pyridin-fumarat, fremgangsmÕte for fremstilling derav, farmas°ytisk preparat som omfatter det, samt anvendelse av forbindelsen for fremstilling a
NO2014001C NO2014001I2 (no) 1993-11-24 2014-01-23 Rupatadin fumarat

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09302460A ES2087818B1 (es) 1993-11-24 1993-11-24 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.

Publications (2)

Publication Number Publication Date
ES2087818A1 true ES2087818A1 (es) 1996-07-16
ES2087818B1 ES2087818B1 (es) 1997-03-16

Family

ID=8283716

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09302460A Expired - Fee Related ES2087818B1 (es) 1993-11-24 1993-11-24 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.

Country Status (2)

Country Link
ES (1) ES2087818B1 (es)
NO (2) NO305436B1 (es)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2120899A1 (es) * 1996-10-07 1998-11-01 Uriach & Cia Sa J Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11- 1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.
ES2311426A1 (es) * 2005-04-27 2009-02-01 Cadila Pharmaceuticals Limited Un procedimiento para la preparacion de rupatadina y sus sales.
EP2402012A2 (en) 2010-06-30 2012-01-04 J. Uriach y Compania S.A. Liquid formulations of rupatadine fumarate
WO2012001120A1 (en) 2010-06-30 2012-01-05 J. Uriach Y Compañía, S.A. Rupatadine salt as an antihistaminic agent
CN102807562A (zh) * 2012-07-31 2012-12-05 东莞达信生物技术有限公司 一种卢帕他定及其盐的制备方法
CN101531654B (zh) * 2009-04-13 2013-07-17 浙江赐富医药有限公司 一种卢帕他定的制备方法
CN103804357A (zh) * 2014-01-02 2014-05-21 珠海金鸿药业股份有限公司 一种富马酸卢帕他定化合物，其合成方法及其药物组合物
CN109734702A (zh) * 2019-03-01 2019-05-10 南京工业大学 一种采用微通道反应装置制备富马酸卢帕他定的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003138A1 (en) * 1986-10-31 1988-05-05 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
EP0396083A1 (en) * 1989-05-01 1990-11-07 Schering Corporation Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
WO1992000293A1 (en) * 1990-06-22 1992-01-09 Schering Corporation Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions
EP0577957A1 (en) * 1992-05-22 1994-01-12 J. URIACH & CIA. S.A. 8-Chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003138A1 (en) * 1986-10-31 1988-05-05 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
EP0396083A1 (en) * 1989-05-01 1990-11-07 Schering Corporation Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
WO1992000293A1 (en) * 1990-06-22 1992-01-09 Schering Corporation Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions
EP0577957A1 (en) * 1992-05-22 1994-01-12 J. URIACH & CIA. S.A. 8-Chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2120899A1 (es) * 1996-10-07 1998-11-01 Uriach & Cia Sa J Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11- 1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.
ES2311426A1 (es) * 2005-04-27 2009-02-01 Cadila Pharmaceuticals Limited Un procedimiento para la preparacion de rupatadina y sus sales.
CN101531654B (zh) * 2009-04-13 2013-07-17 浙江赐富医药有限公司 一种卢帕他定的制备方法
WO2012001120A1 (en) 2010-06-30 2012-01-05 J. Uriach Y Compañía, S.A. Rupatadine salt as an antihistaminic agent
WO2012001093A2 (en) 2010-06-30 2012-01-05 J. Uriach Y Compañía, S.A. Liquid formulations of rupatadine fumarate
EP2402012A3 (en) * 2010-06-30 2012-02-29 J. Uriach y Compania S.A. Liquid formulations of rupatadine fumarate
WO2012001093A3 (en) * 2010-06-30 2012-04-12 J. Uriach Y Compañía, S.A. Liquid formulations of rupatadine fumarate
CN102958926A (zh) * 2010-06-30 2013-03-06 J·乌里亚奇·Y股份有限公司 作为抗组胺剂的卢帕他定盐
EP2402012A2 (en) 2010-06-30 2012-01-04 J. Uriach y Compania S.A. Liquid formulations of rupatadine fumarate
CN102958926B (zh) * 2010-06-30 2014-04-23 J·乌里亚奇·Y股份有限公司 抗组胺剂
CN102807562A (zh) * 2012-07-31 2012-12-05 东莞达信生物技术有限公司 一种卢帕他定及其盐的制备方法
CN103804357A (zh) * 2014-01-02 2014-05-21 珠海金鸿药业股份有限公司 一种富马酸卢帕他定化合物，其合成方法及其药物组合物
CN109734702A (zh) * 2019-03-01 2019-05-10 南京工业大学 一种采用微通道反应装置制备富马酸卢帕他定的方法
CN109734702B (zh) * 2019-03-01 2020-07-03 南京工业大学 一种采用微通道反应装置制备富马酸卢帕他定的方法

Also Published As

Publication number Publication date
NO944487L (no) 1995-05-26
NO305436B1 (no) 1999-05-31
NO944487D0 (no) 1994-11-23
NO2014001I1 (no) 2014-06-02
ES2087818B1 (es) 1997-03-16
NO2014001I2 (no) 2015-08-24

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Effective date: 19960716

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