ES2120899A1 - Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11- 1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina. - Google Patents

Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11- 1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.

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Publication number
ES2120899A1
ES2120899A1 ES09602107A ES9602107A ES2120899A1 ES 2120899 A1 ES2120899 A1 ES 2120899A1 ES 09602107 A ES09602107 A ES 09602107A ES 9602107 A ES9602107 A ES 9602107A ES 2120899 A1 ES2120899 A1 ES 2120899A1
Authority
ES
Spain
Prior art keywords
methyl
formula
piperidinylideno
pyridenyl
cyclohepta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09602107A
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English (en)
Other versions
ES2120899B1 (es
Inventor
Elena Carceller
Perez J Jimenez
Jordi Salas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
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Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES9602107A priority Critical patent/ES2120899B1/es
Publication of ES2120899A1 publication Critical patent/ES2120899A1/es
Application granted granted Critical
Publication of ES2120899B1 publication Critical patent/ES2120899B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

PROCEDIMIENTO PARA LA PREPARACION DE LA 8-CLORO-6,11-DIHIDRO-11-[1-[(5- METIL-3-PIRIDINIL)METIL]-4-PIPERIDINILIDENO]-5H-BENZO[5,6]CICLOHEPTA[1,2-B]- PIRIDINA DE FORMULA I QUE COMPRENDE HACER REACCIONAR LA CETONA DE FORMULA II CON UN COMPUESTO METALADO DE FORMULA III, DONDE M REPRESENTA UN METAL, EN EL SENO DE UN DISOLVENTE INERTE PARA DAR UN ALCOHOL DE FORMULA IV, EL CUAL SE DESHIDRATA PARA DAR UN COMPUESTO DE FORMULA I; Y OPCIONALMENTE, SE TRANSFORMA EL COMPUESTO I EN UNA SAL FARMACEUTICAMENTE ACEPTABLE.
ES9602107A 1996-10-07 1996-10-07 Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11-(1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina. Expired - Fee Related ES2120899B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9602107A ES2120899B1 (es) 1996-10-07 1996-10-07 Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11-(1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9602107A ES2120899B1 (es) 1996-10-07 1996-10-07 Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11-(1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.

Publications (2)

Publication Number Publication Date
ES2120899A1 true ES2120899A1 (es) 1998-11-01
ES2120899B1 ES2120899B1 (es) 1999-06-16

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Application Number Title Priority Date Filing Date
ES9602107A Expired - Fee Related ES2120899B1 (es) 1996-10-07 1996-10-07 Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11-(1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.

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ES (1) ES2120899B1 (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018366A1 (en) * 2000-08-29 2002-03-07 Ranbaxy Laboratories Limited Process for the synthesis of n-(5-methylnicotinoyl)-4-hydroxypiperidine, a key intermediate of rupatadine
WO2013000406A1 (zh) 2011-06-28 2013-01-03 Lin Tongjun 抗-变态反应的苯并环庚并噻吩衍生物
CN102964295A (zh) * 2012-12-17 2013-03-13 寿光富康制药有限公司 一种2-取代-4-（哌啶基甲基）吡啶的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042421A1 (es) * 1992-05-22 1993-12-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
ES2087818A1 (es) * 1993-11-24 1996-07-16 Uriach & Cia Sa J 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042421A1 (es) * 1992-05-22 1993-12-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
ES2087818A1 (es) * 1993-11-24 1996-07-16 Uriach & Cia Sa J 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CARCELLER, E y col. [(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine Derivatives as Dual Antagonists of PAF and Histamine. J. Med. Chem. 1994, Vol. 37, N‘ 17, pßginas 2697-2703, en particular pßgina 2699, esquema 1, compuesto 19; pßginas 2697-2699: Chemistry. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018366A1 (en) * 2000-08-29 2002-03-07 Ranbaxy Laboratories Limited Process for the synthesis of n-(5-methylnicotinoyl)-4-hydroxypiperidine, a key intermediate of rupatadine
WO2013000406A1 (zh) 2011-06-28 2013-01-03 Lin Tongjun 抗-变态反应的苯并环庚并噻吩衍生物
CN102964295A (zh) * 2012-12-17 2013-03-13 寿光富康制药有限公司 一种2-取代-4-（哌啶基甲基）吡啶的制备方法
CN102964295B (zh) * 2012-12-17 2014-08-20 寿光富康制药有限公司 一种2-取代-4-（哌啶基甲基）吡啶的制备方法

Also Published As

Publication number Publication date
ES2120899B1 (es) 1999-06-16

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