NL300384I1 - 8-chloor-11-[1-[ (5-methyl-3-pyridyl)methyl)-4-piperidylideen)-6,11-dihydro-5H-benzo[5,6]cycloheptal(1,2-b)pyridine - Google Patents

8-chloor-11-[1-[ (5-methyl-3-pyridyl)methyl)-4-piperidylideen)-6,11-dihydro-5H-benzo[5,6]cycloheptal(1,2-b)pyridine

Info

Publication number
NL300384I1
NL300384I1 NL300384C NL300384C NL300384I1 NL 300384 I1 NL300384 I1 NL 300384I1 NL 300384 C NL300384 C NL 300384C NL 300384 C NL300384 C NL 300384C NL 300384 I1 NL300384 I1 NL 300384I1
Authority
NL
Netherlands
Prior art keywords
methyl
benzo
pyridyl
pyridine
chloro
Prior art date
Application number
NL300384C
Other languages
English (en)
Other versions
NL300384I2 (nl
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of NL300384I1 publication Critical patent/NL300384I1/nl
Publication of NL300384I2 publication Critical patent/NL300384I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
NL300384C 1992-05-22 2009-04-07 8-chloor-11-\[1-\[(5-methyl-3-pyridyl)methyl\)] NL300384I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201054A ES2042421B1 (es) 1992-05-22 1992-05-22 Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.

Publications (2)

Publication Number Publication Date
NL300384I1 true NL300384I1 (nl) 2009-06-02
NL300384I2 NL300384I2 (nl) 2009-08-03

Family

ID=8277082

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300384C NL300384I2 (nl) 1992-05-22 2009-04-07 8-chloor-11-\[1-\[(5-methyl-3-pyridyl)methyl\)]

Country Status (13)

Country Link
US (2) US5407941A (nl)
EP (1) EP0577957B1 (nl)
JP (1) JP2730612B2 (nl)
KR (1) KR0156518B1 (nl)
AT (1) ATE124939T1 (nl)
CA (1) CA2096318C (nl)
DE (2) DE69300255T2 (nl)
DK (1) DK0577957T3 (nl)
ES (2) ES2042421B1 (nl)
HK (1) HK1006169A1 (nl)
LU (1) LU91121I2 (nl)
MX (1) MX9302958A (nl)
NL (1) NL300384I2 (nl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en) * 1993-05-20 1996-05-07 Immunopharmaceutics, Inc. N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) * 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) * 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
EP0626174A3 (en) * 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Method and composition for the prophylaxis and / or treatment of underactive organs.
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
ES2087818B1 (es) * 1993-11-24 1997-03-16 Uriach & Cia Sa J 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
US5977117A (en) * 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) * 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
ES2120899B1 (es) * 1996-10-07 1999-06-16 Uriach & Cia Sa J Procedimiento para la preparacion de la 8-cloro-6, 11-dihidro-11-(1-(5-metil-3-piridinil)metil)-4-piperidinilideno)-5h-benzo(5,6) ciclohepta (1,2-b)piridina.
BR9812258A (pt) 1997-04-28 2000-07-25 Texas Biotechnology Corp Sulfonamidas para tratamento de distúrbios mediados por endotelina
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
WO1999019322A1 (en) * 1997-10-10 1999-04-22 Schering Corporation ETHYL 4-(8-CHLORO-5, 6-DIHYDRO-11H- BENZO[5,6]CYCLOHEPTA [1,2-b]PYRIDIN -11-YLIDENE)-1- PIPERIDENE CARBOXYLATE POLYMORPH
WO2001045676A2 (en) * 1999-12-20 2001-06-28 Schering Corporation Extended release oral dosage composition
SK287684B6 (sk) * 1999-12-20 2011-06-06 Schering Corporation Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
AU2001284320A1 (en) * 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Process for the synthesis of n-(5-methylnicotinoyl)-4-hydroxypiperidine, a key intermediate of rupatadine
ES2232332T3 (es) * 2003-03-12 2007-08-16 Teva Pharmaceutical Industries Ltd Composiciones farmaceuticas estables de desloratadina.
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
WO2006103688A1 (en) * 2005-04-01 2006-10-05 Hetero Drugs Limited A novel crystalline form of rupatadine free base
ES2311426B1 (es) * 2005-04-27 2009-12-22 Cadila Pharmaceuticals Limited Un procedimiento para la preparacion de rupatadina y sus sales.
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
CN101497606B (zh) * 2008-01-29 2014-04-02 东莞达信生物技术有限公司 卢帕他定或其盐的制备方法
CA2798028A1 (en) 2010-06-30 2012-01-05 J. Uriach Y Compania S.A. Liquid formulations of rupatadine fumarate
WO2012001120A1 (en) 2010-06-30 2012-01-05 J. Uriach Y Compañía, S.A. Rupatadine salt as an antihistaminic agent
WO2013000406A1 (zh) * 2011-06-28 2013-01-03 Lin Tongjun 抗-变态反应的苯并环庚并噻吩衍生物
CN102653535A (zh) * 2011-12-09 2012-09-05 东莞达信生物技术有限公司 卢帕他定游离碱及其制取方法
EP2824103B1 (en) 2013-07-09 2016-04-27 Cadila Pharmaceuticals Limited An improved process for the preparation of Rupatadine Fumarate
US20180187263A1 (en) 2017-01-05 2018-07-05 Iowa State University Research Foundation, Inc. Kits for diagnostic detection and prevention of feedlot bovine respiratory disease
TWI825013B (zh) 2017-04-19 2023-12-11 日商帝國製藥股份有限公司 含有盧帕他定（ｒｕｐａｔａｄｉｎｅ）之貼附劑
CN109096251B (zh) * 2018-09-26 2020-11-03 合肥医工医药股份有限公司 具有组胺受体双重拮抗活性的化合物及用途
CN109734702B (zh) * 2019-03-01 2020-07-03 南京工业大学 一种采用微通道反应装置制备富马酸卢帕他定的方法
MX2022005102A (es) * 2019-10-31 2022-05-30 Jd Bioscience Inc Compuesto triciclico y uso farmaceutico del mismo.
EP4247331A1 (en) 2020-11-18 2023-09-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
AU570306B2 (en) * 1984-02-15 1988-03-10 Schering Corporation 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts.
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
DE68926976T2 (de) * 1988-04-28 1997-02-27 Schering Corp Kondensierte polyzyklische Verbindungen, Zusammenstellungen, Verfahren zur Herstellung und deren Anwendung als PAF-antagonistische, antihistaminische und/oder anti-inflammatorische Agenzien
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same
IL98572A (en) * 1990-06-22 1995-07-31 Schering Corp Bite-benzo or benzopyrido compounds Cyclohepta piperidine, piperidylidene and piperazine, preparations and methods of use.
GB9102997D0 (en) * 1991-02-13 1991-03-27 Pfizer Ltd Therapeutic agents
US5360907A (en) * 1993-06-14 1994-11-01 G.D. Searle & Co. Pyrrolo[3,2-B]pyridinylalkyl benzamide derivatives

Also Published As

Publication number Publication date
CA2096318C (en) 1998-06-23
KR930023359A (ko) 1993-12-18
EP0577957B1 (en) 1995-07-12
DE122008000031I1 (de) 2008-10-02
DE69300255D1 (de) 1995-08-17
JP2730612B2 (ja) 1998-03-25
LU91121I2 (fr) 2005-01-03
ATE124939T1 (de) 1995-07-15
KR0156518B1 (ko) 1998-11-16
ES2042421A1 (es) 1993-12-01
US5407941A (en) 1995-04-18
NL300384I2 (nl) 2009-08-03
DE122008000031I2 (de) 2010-12-30
DK0577957T3 (da) 1995-12-04
CA2096318A1 (en) 1993-11-23
MX9302958A (es) 1993-11-01
HK1006169A1 (en) 1999-02-12
EP0577957A1 (en) 1994-01-12
DE69300255T2 (de) 1996-01-04
ES2076817T3 (es) 1995-11-01
ES2042421B1 (es) 1994-08-01
JPH0687856A (ja) 1994-03-29
US5476856A (en) 1995-12-19

Similar Documents

Publication Publication Date Title
NL300384I1 (nl) 8-chloor-11-[1-[ (5-methyl-3-pyridyl)methyl)-4-piperidylideen)-6,11-dihydro-5H-benzo[5,6]cycloheptal(1,2-b)pyridine
DE3573600D1 (en) 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzoû5,6¨cyclohepta-û1,2-b¨pyridine and its salts, processes for the production thereof and pharmaceutical compositions containing these compounds
HU202520B (en) Process for producing 6,11-dihydro-11-(4-piperidinylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridines and pharmaceutical compositions comprising same
NZ501417A (en) Crystalline polymorphs of descarbonylethoxyloratadine (8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6] cyclohepta[1,2-b]pyridine) and methods for their use
AU8854091A (en) Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use
HU9402462D0 (en) Process for the preparation of 0-[4-(4-piperidinyl)butyl]-tyrosine derivatives as fibrinogen receptor antagonists
NO20005485D0 (no) Orale preparater inneholdende 8-klor-6,11-dihydro-11-(4- piperyliden)-5H-benzo-[5,6]syklohepta[1,2-b]pyridin
GB9323162D0 (en) 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
ES2087026A1 (es) Nuevo derivado de la benzo(5,6)ciclohepta- (1.2-b) piridina.
HU9204112D0 (en) Method for producing new benzole derivatives condensed with 5-member ring as well as pharmaceutical preparatives containing these compounds
AU9683798A (en) Ethyl 4-(8-chloro-5, 6-dihydro-11h- benzo{5,6}cyclohepta {1,2-b}pyridin -11-ylidene)-1- piperidene carboxylate polymorph
ZA932721B (en) Substituted Indolizino[1,2-b]quinolinones
NZ231726A (en) 6,11 dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridines and pharmaceutical compositions