DE1131846B - Verfahren zur Inaktivierung von Poliomyelitisviren - Google Patents
Verfahren zur Inaktivierung von PoliomyelitisvirenInfo
- Publication number
- DE1131846B DE1131846B DEB55993A DEB0055993A DE1131846B DE 1131846 B DE1131846 B DE 1131846B DE B55993 A DEB55993 A DE B55993A DE B0055993 A DEB0055993 A DE B0055993A DE 1131846 B DE1131846 B DE 1131846B
- Authority
- DE
- Germany
- Prior art keywords
- formaldehyde
- inactivating
- poliomyelitis
- viruses
- inactivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 title claims description 13
- 208000000474 Poliomyelitis Diseases 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 8
- 230000000415 inactivating effect Effects 0.000 title claims description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 23
- 230000002779 inactivation Effects 0.000 claims description 9
- 239000002738 chelating agent Substances 0.000 claims description 7
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- 102000004338 Transferrin Human genes 0.000 description 2
- 108090000901 Transferrin Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 2
- RNMCCPMYXUKHAZ-UHFFFAOYSA-N 2-[3,3-diamino-1,2,2-tris(carboxymethyl)cyclohexyl]acetic acid Chemical compound NC1(N)CCCC(CC(O)=O)(CC(O)=O)C1(CC(O)=O)CC(O)=O RNMCCPMYXUKHAZ-UHFFFAOYSA-N 0.000 description 1
- QDHGQJQZPJPKJK-UHFFFAOYSA-N 2-[carboxymethyl-(2,4,6-trioxo-1,3-diazinan-5-yl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C1C(=O)NC(=O)NC1=O QDHGQJQZPJPKJK-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical class CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32661—Methods of inactivation or attenuation
- C12N2770/32663—Methods of inactivation or attenuation by chemical treatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB55993A DE1131846B (de) | 1959-12-22 | 1959-12-22 | Verfahren zur Inaktivierung von Poliomyelitisviren |
| CH1412560A CH399653A (de) | 1959-12-22 | 1960-12-16 | Verfahren zur Inaktivierung von Poliomyelitisviren |
| GB43811/60A GB949684A (en) | 1959-12-22 | 1960-12-20 | Process for inactivating poliomyelitis virus |
| BE598471A BE598471A (fr) | 1959-12-22 | 1960-12-22 | Procédé pour rendre inactifs des virus de poliomyélite |
| SE12424/60A SE309826B (fr) | 1959-12-22 | 1960-12-22 | |
| FR856343A FR1023M (fr) | 1959-12-22 | 1961-03-21 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB55993A DE1131846B (de) | 1959-12-22 | 1959-12-22 | Verfahren zur Inaktivierung von Poliomyelitisviren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1131846B true DE1131846B (de) | 1962-06-20 |
Family
ID=6971173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEB55993A Pending DE1131846B (de) | 1959-12-22 | 1959-12-22 | Verfahren zur Inaktivierung von Poliomyelitisviren |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE598471A (fr) |
| CH (1) | CH399653A (fr) |
| DE (1) | DE1131846B (fr) |
| FR (1) | FR1023M (fr) |
| GB (1) | GB949684A (fr) |
| SE (1) | SE309826B (fr) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1042179B (de) * | 1957-07-11 | 1958-10-30 | Pasteur Institut | Verfahren zur Herstellung antigenhaltiger Impfstoffe |
-
1959
- 1959-12-22 DE DEB55993A patent/DE1131846B/de active Pending
-
1960
- 1960-12-16 CH CH1412560A patent/CH399653A/de unknown
- 1960-12-20 GB GB43811/60A patent/GB949684A/en not_active Expired
- 1960-12-22 BE BE598471A patent/BE598471A/fr unknown
- 1960-12-22 SE SE12424/60A patent/SE309826B/xx unknown
-
1961
- 1961-03-21 FR FR856343A patent/FR1023M/fr active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1042179B (de) * | 1957-07-11 | 1958-10-30 | Pasteur Institut | Verfahren zur Herstellung antigenhaltiger Impfstoffe |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1023M (fr) | 1961-12-26 |
| CH399653A (de) | 1965-09-30 |
| BE598471A (fr) | 1961-06-22 |
| SE309826B (fr) | 1969-04-08 |
| GB949684A (en) | 1964-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT402891B (de) | Verfahren zur herstellung eines inaktivierten blutproduktes | |
| EP0311950A3 (fr) | Procédé de préparation d'une solution stérile de protéine de plasma, qui contient du fibrinogène et du facteur de coagulation XIII | |
| DE2546166A1 (de) | Gegerbte thrombozyten | |
| DE1924303A1 (de) | AEthylaethylenimin als Inaktivierungsmittel | |
| DE4137996A1 (de) | Verfahren zur herstellung eines virussicheren thrombinkonzentrates | |
| DE1924304C3 (de) | Diäthylaminoäthyldextran (DEAE-D) als Adjuvans für Impfstoffe zur aktiven Immunisierung von Säugetieren | |
| DE1131846B (de) | Verfahren zur Inaktivierung von Poliomyelitisviren | |
| DE69005588T2 (de) | Verfahren zum beschleunigten Altern und zur Behandlung von Wurzelstöcken von Schwertlilien. | |
| AT222274B (fr) | ||
| DE68917709T2 (de) | Verfahren zur Herstellung eines Pertussis-Toxin-Toxoides. | |
| DE2528584A1 (de) | Verfahren zur inaktivierung der virusinfektiositaet unter gleichzeitiger stabilisierung von virusantigenen | |
| DE1492243B2 (de) | Injizierbare Impfstoffe | |
| DE543604C (de) | Verfahren zur Dauersterilisierung von Heilseren | |
| DE2034118A1 (en) | Xenogenic nucleic acids for enhancing antigenicity - of peptides and proteins | |
| DE940315C (de) | Verfahren zur Herstellung von Lymphe gegen Schweinepest | |
| EP0025116A1 (fr) | Procédé pour tester l'inactivation de vaccins et l'innocuité de produits sanguins ainsi que l'activité de produits chimiothérapeutiques ou de produits de désinfection contre l'hépatite virale et procédé pour l'obtention d'antiqènes d'hépatite virale | |
| AT376883B (de) | Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern | |
| AT376884B (de) | Verfahren zur inaktivierung von vermehrungsfaehigen krankeitserregern | |
| CH430052A (de) | Verfahren zur Herstellung eines inaktivierten Pockenimpfstoffes | |
| DE959048C (de) | Verfahren zur Herstellung eines Impfstoffes zur aktiven Schutzimpfung gegen spinale Kinderlaehmung | |
| DE499524C (de) | Verfahren zur Gewinnung antirachitisch wirksamer Stoffe mit definiertem Absorptionsspektrum | |
| AT200257B (fr) | ||
| DE1792050A1 (de) | Verfahren zur Herstellung eines Mittels zur Bekaempfung von Geschwulstkrankheiten | |
| DE889579C (de) | Verfahren zur Verbesserung von Tabak, insbesondere von solchem deutscher Herkunft | |
| AT216142B (de) | Verfahren zur Herstellung von Depotimpfstoffen |