DE10261807A1 - Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel - Google Patents
Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel Download PDFInfo
- Publication number
- DE10261807A1 DE10261807A1 DE10261807A DE10261807A DE10261807A1 DE 10261807 A1 DE10261807 A1 DE 10261807A1 DE 10261807 A DE10261807 A DE 10261807A DE 10261807 A DE10261807 A DE 10261807A DE 10261807 A1 DE10261807 A1 DE 10261807A1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- trideutero
- dihydroxyphenyl
- deuterated
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10261807A DE10261807A1 (de) | 2002-12-19 | 2002-12-19 | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
NZ541047A NZ541047A (en) | 2002-12-19 | 2003-12-18 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
US10/539,845 US8168820B2 (en) | 2002-12-19 | 2003-12-18 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
DE50312224T DE50312224D1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
PCT/DE2003/004203 WO2004056724A1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
US14/464,444 USRE46629E1 (en) | 2002-12-19 | 2003-12-18 | Deuterated catecholamine derivatives and medicaments compromising said compounds |
AT03782168T ATE451340T1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
MXPA05006408A MXPA05006408A (es) | 2002-12-19 | 2003-12-18 | Derivados deuterizados de catecolamina y medicamentos comprendiendo estos compuestos. |
PL377584A PL219269B1 (pl) | 2002-12-19 | 2003-12-18 | Deuterowane pochodne katecholoaminy i ich zastosowanie oraz preparaty farmaceutyczne, zawierające te związki |
CA2513088A CA2513088C (en) | 2002-12-19 | 2003-12-18 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
AU2003289841A AU2003289841B2 (en) | 2002-12-19 | 2003-12-18 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
PT03782168T PT1613571E (pt) | 2002-12-19 | 2003-12-18 | Derivados de catecolamina deuterados bem como medicamentos contendo estes compostos |
CN200380108990A CN100584807C (zh) | 2002-12-19 | 2003-12-18 | 氘化的儿茶酚胺衍生物以及含有该化合物的药物 |
DK03782168.3T DK1613571T3 (da) | 2002-12-19 | 2003-12-18 | Deutererede catecholaminderivater og lægemidler indeholdende disse forbidelser |
JP2004561054A JP2006510686A (ja) | 2002-12-19 | 2003-12-18 | 重水素化カテコールアミン誘導体ならびにそれらの化合物を含有する医薬品 |
ES03782168T ES2337046T3 (es) | 2002-12-19 | 2003-12-18 | Derivados deuterados de catecolamina y medicamentos que comprenden dichos compuestos. |
EP03782168A EP1613571B1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
EA200500958A EA009258B1 (ru) | 2002-12-19 | 2003-12-18 | Дейтерированные производные катехоламина, а также лекарственные средства, содержащие эти соединения |
IL169203A IL169203A (en) | 2002-12-19 | 2005-06-16 | History of catecholamines that have passed through the deuterium, pharmaceutical preparations containing them and drugs containing them or their mixtures together with enzyme inhibitors |
HK06106498.8A HK1086548A1 (en) | 2002-12-19 | 2006-06-07 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
JP2011243559A JP2012087124A (ja) | 2002-12-19 | 2011-11-07 | 重水素化カテコールアミン誘導体ならびにそれらの化合物を含有する医薬品 |
JP2015134445A JP2015212287A (ja) | 2002-12-19 | 2015-07-03 | 重水素化カテコールアミン誘導体ならびにそれらの化合物を含有する医薬品 |
JP2015134444A JP2015178537A (ja) | 2002-12-19 | 2015-07-03 | 重水素化カテコールアミン誘導体ならびにそれらの化合物を含有する医薬品 |
JP2017132662A JP2018193356A (ja) | 2002-12-19 | 2017-07-06 | 重水素化カテコールアミン誘導体ならびにそれらの化合物を含有する医薬品 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10261807A DE10261807A1 (de) | 2002-12-19 | 2002-12-19 | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DE10261807A1 true DE10261807A1 (de) | 2004-07-01 |
Family
ID=32404400
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10261807A Withdrawn DE10261807A1 (de) | 2002-12-19 | 2002-12-19 | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
DE50312224T Expired - Lifetime DE50312224D1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE50312224T Expired - Lifetime DE50312224D1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
Country Status (18)
Country | Link |
---|---|
US (2) | USRE46629E1 (ja) |
EP (1) | EP1613571B1 (ja) |
JP (5) | JP2006510686A (ja) |
CN (1) | CN100584807C (ja) |
AT (1) | ATE451340T1 (ja) |
AU (1) | AU2003289841B2 (ja) |
CA (1) | CA2513088C (ja) |
DE (2) | DE10261807A1 (ja) |
DK (1) | DK1613571T3 (ja) |
EA (1) | EA009258B1 (ja) |
ES (1) | ES2337046T3 (ja) |
HK (1) | HK1086548A1 (ja) |
IL (1) | IL169203A (ja) |
MX (1) | MXPA05006408A (ja) |
NZ (1) | NZ541047A (ja) |
PL (1) | PL219269B1 (ja) |
PT (1) | PT1613571E (ja) |
WO (1) | WO2004056724A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007093450A2 (en) * | 2006-02-17 | 2007-08-23 | Birds Pharma Gmbh Berolina Innovative Research & Development Services | Deuterated catecholamine derivatives and medicaments comprising said compounds |
USRE46629E1 (en) | 2002-12-19 | 2017-12-12 | Teva Pharmaceuticals International Gmbh | Deuterated catecholamine derivatives and medicaments compromising said compounds |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100360109B1 (ko) * | 2000-12-19 | 2002-11-07 | 주식회사 포스코 | 미분을 재활용하는 분철광석의 유동층식 용융환원장치 및이를 이용한 용융환원방법 |
JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ[d][1,3]ジオキソールおよびその誘導体の合成 |
US9763904B2 (en) | 2013-02-05 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds |
KR20150115807A (ko) | 2013-02-05 | 2015-10-14 | 임파 악치엔게젤샤프트 | 위치-특이적 비대칭 중수소 풍부 카테콜아민 유도체 및 상기 화합물을 포함하는 약제 |
BR112016000338A8 (pt) * | 2013-07-08 | 2020-01-07 | Auspex Pharmaceuticals Inc | composto enriquecido em deutério de fórmula estrutural i, composição farmacêutica, e usos de um composto |
EP2918266A1 (en) | 2014-03-11 | 2015-09-16 | CDRD Berolina AB | Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease |
WO2017060870A1 (en) | 2015-10-09 | 2017-04-13 | Hermann Russ | Combination of deuterated levodopa with carbidopa and opicapone for the treatment of parkinson`s disease |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699158A (en) * | 1969-08-25 | 1972-10-17 | Merck & Co Inc | Selective deuteration of tyrosine, aspartic and glutamic acids |
US3769424A (en) | 1970-10-01 | 1973-10-30 | Merck & Co Inc | Composition and method of treating dopamine deficiency in brain tissue |
DE2049115C3 (de) | 1970-10-06 | 1981-07-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa) |
US4663349A (en) | 1985-12-30 | 1987-05-05 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
ATE76747T1 (de) * | 1986-06-10 | 1992-06-15 | Chiesi Farma Spa | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
JP2718504B2 (ja) * | 1988-02-22 | 1998-02-25 | アローンサクル シャオバニー | 中枢神経系疾患治療法及びアルツハイマー病診断法 |
IT1226902B (it) | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi del levodopa |
US5354885A (en) | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
IL119417A (en) * | 1996-10-13 | 2003-02-12 | Moshe Kushnir | Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease |
DE69832984T2 (de) * | 1997-10-08 | 2006-09-21 | Isotechnika, Inc., Edmonton | DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN |
US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
NO309305B1 (no) | 1999-02-19 | 2001-01-15 | Norsk Hydro As | Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater |
EP1104760B1 (en) * | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
JP2001203263A (ja) | 2000-01-20 | 2001-07-27 | Hitachi Ltd | 半導体集積回路装置の製造方法および半導体集積回路装置 |
JP2002097137A (ja) | 2000-07-19 | 2002-04-02 | Junichi Sudo | パーキンソン病の予防および/または治療剤 |
DE10123129A1 (de) | 2001-05-02 | 2002-11-14 | Berolina Drug Dev Ab Svedala | Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel |
DE10261807A1 (de) | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
-
2002
- 2002-12-19 DE DE10261807A patent/DE10261807A1/de not_active Withdrawn
-
2003
- 2003-12-18 CA CA2513088A patent/CA2513088C/en not_active Expired - Fee Related
- 2003-12-18 WO PCT/DE2003/004203 patent/WO2004056724A1/de active Application Filing
- 2003-12-18 PT PT03782168T patent/PT1613571E/pt unknown
- 2003-12-18 AT AT03782168T patent/ATE451340T1/de active
- 2003-12-18 EP EP03782168A patent/EP1613571B1/de not_active Expired - Lifetime
- 2003-12-18 JP JP2004561054A patent/JP2006510686A/ja active Pending
- 2003-12-18 MX MXPA05006408A patent/MXPA05006408A/es active IP Right Grant
- 2003-12-18 NZ NZ541047A patent/NZ541047A/en not_active IP Right Cessation
- 2003-12-18 CN CN200380108990A patent/CN100584807C/zh not_active Expired - Fee Related
- 2003-12-18 DE DE50312224T patent/DE50312224D1/de not_active Expired - Lifetime
- 2003-12-18 AU AU2003289841A patent/AU2003289841B2/en not_active Ceased
- 2003-12-18 DK DK03782168.3T patent/DK1613571T3/da active
- 2003-12-18 EA EA200500958A patent/EA009258B1/ru not_active IP Right Cessation
- 2003-12-18 US US14/464,444 patent/USRE46629E1/en not_active Expired - Fee Related
- 2003-12-18 US US10/539,845 patent/US8168820B2/en not_active Ceased
- 2003-12-18 ES ES03782168T patent/ES2337046T3/es not_active Expired - Lifetime
- 2003-12-18 PL PL377584A patent/PL219269B1/pl unknown
-
2005
- 2005-06-16 IL IL169203A patent/IL169203A/en active IP Right Grant
-
2006
- 2006-06-07 HK HK06106498.8A patent/HK1086548A1/xx not_active IP Right Cessation
-
2011
- 2011-11-07 JP JP2011243559A patent/JP2012087124A/ja active Pending
-
2015
- 2015-07-03 JP JP2015134445A patent/JP2015212287A/ja not_active Withdrawn
- 2015-07-03 JP JP2015134444A patent/JP2015178537A/ja active Pending
-
2017
- 2017-07-06 JP JP2017132662A patent/JP2018193356A/ja active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE46629E1 (en) | 2002-12-19 | 2017-12-12 | Teva Pharmaceuticals International Gmbh | Deuterated catecholamine derivatives and medicaments compromising said compounds |
WO2007093450A2 (en) * | 2006-02-17 | 2007-08-23 | Birds Pharma Gmbh Berolina Innovative Research & Development Services | Deuterated catecholamine derivatives and medicaments comprising said compounds |
WO2007093450A3 (en) * | 2006-02-17 | 2007-09-27 | Birds Pharma Gmbh Berolina Inn | Deuterated catecholamine derivatives and medicaments comprising said compounds |
US8247603B2 (en) | 2006-02-17 | 2012-08-21 | Birds Pharma Gmbh Berolina Innovative | Deuterated catecholamine derivatives and medicaments comprising said compounds |
EA017983B1 (ru) * | 2006-02-17 | 2013-04-30 | Бедс Фарма Гмбх Беролина Инновейтив Ресёч Энд Девелопмент Сёвисиз | Дейтерированные производные катехоламина и лекарственные средства, содержащие указанные соединения |
EP3101001A1 (en) | 2006-02-17 | 2016-12-07 | ratiopharm GmbH | Deuterated catecholamine derivatives and medicaments comprising said compounds |
USRE46555E1 (en) | 2006-02-17 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Deuterated catecholamine derivatives and medicaments comprising said compounds |
Also Published As
Publication number | Publication date |
---|---|
IL169203A (en) | 2012-05-31 |
NZ541047A (en) | 2008-09-26 |
CN100584807C (zh) | 2010-01-27 |
DK1613571T3 (da) | 2010-04-12 |
AU2003289841A1 (en) | 2004-07-14 |
US8168820B2 (en) | 2012-05-01 |
JP2015212287A (ja) | 2015-11-26 |
WO2004056724A1 (de) | 2004-07-08 |
PL219269B1 (pl) | 2015-04-30 |
EA009258B1 (ru) | 2007-12-28 |
JP2012087124A (ja) | 2012-05-10 |
ES2337046T3 (es) | 2010-04-20 |
JP2006510686A (ja) | 2006-03-30 |
US20060135615A1 (en) | 2006-06-22 |
ATE451340T1 (de) | 2009-12-15 |
EP1613571B1 (de) | 2009-12-09 |
EP1613571A1 (de) | 2006-01-11 |
EA200500958A1 (ru) | 2006-02-24 |
MXPA05006408A (es) | 2006-03-08 |
PT1613571E (pt) | 2010-02-10 |
PL377584A1 (pl) | 2006-02-06 |
JP2015178537A (ja) | 2015-10-08 |
DE50312224D1 (de) | 2010-01-21 |
HK1086548A1 (en) | 2006-09-22 |
AU2003289841B2 (en) | 2010-01-28 |
CN1738782A (zh) | 2006-02-22 |
CA2513088A1 (en) | 2004-07-08 |
CA2513088C (en) | 2012-03-06 |
USRE46629E1 (en) | 2017-12-12 |
JP2018193356A (ja) | 2018-12-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8127 | New person/name/address of the applicant |
Owner name: BDD BEROLINA DRUG DEVELOPMENT GMBH, 15366 NEUENHAG |
|
8141 | Disposal/no request for examination |