DK1613571T3 - Deutererede catecholaminderivater og lægemidler indeholdende disse forbidelser - Google Patents
Deutererede catecholaminderivater og lægemidler indeholdende disse forbidelserInfo
- Publication number
- DK1613571T3 DK1613571T3 DK03782168.3T DK03782168T DK1613571T3 DK 1613571 T3 DK1613571 T3 DK 1613571T3 DK 03782168 T DK03782168 T DK 03782168T DK 1613571 T3 DK1613571 T3 DK 1613571T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- catecholamine derivatives
- deuterated catecholamine
- well
- drugs containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10261807A DE10261807A1 (de) | 2002-12-19 | 2002-12-19 | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
| PCT/DE2003/004203 WO2004056724A1 (de) | 2002-12-19 | 2003-12-18 | Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1613571T3 true DK1613571T3 (da) | 2010-04-12 |
Family
ID=32404400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03782168.3T DK1613571T3 (da) | 2002-12-19 | 2003-12-18 | Deutererede catecholaminderivater og lægemidler indeholdende disse forbidelser |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | USRE46629E1 (da) |
| EP (1) | EP1613571B1 (da) |
| JP (5) | JP2006510686A (da) |
| CN (1) | CN100584807C (da) |
| AT (1) | ATE451340T1 (da) |
| AU (1) | AU2003289841B2 (da) |
| CA (1) | CA2513088C (da) |
| DE (2) | DE10261807A1 (da) |
| DK (1) | DK1613571T3 (da) |
| EA (1) | EA009258B1 (da) |
| ES (1) | ES2337046T3 (da) |
| HK (1) | HK1086548A1 (da) |
| IL (1) | IL169203A (da) |
| MX (1) | MXPA05006408A (da) |
| NZ (1) | NZ541047A (da) |
| PL (1) | PL219269B1 (da) |
| PT (1) | PT1613571E (da) |
| WO (1) | WO2004056724A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100360109B1 (ko) * | 2000-12-19 | 2002-11-07 | 주식회사 포스코 | 미분을 재활용하는 분철광석의 유동층식 용융환원장치 및이를 이용한 용융환원방법 |
| DE10261807A1 (de) | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
| ME02508B (me) | 2006-02-17 | 2017-06-20 | Ratiopharm Gmbh | Deuterisani derivati kateholamina i medikamenti koji obuhvataju pomenuta jedinjenja |
| CA2698808A1 (en) | 2007-09-13 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
| CN104968643B (zh) | 2013-02-05 | 2020-03-03 | 梯瓦制药国际有限责任公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
| US9763904B2 (en) | 2013-02-05 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds |
| KR20160041912A (ko) * | 2013-07-08 | 2016-04-18 | 오스펙스 파마슈티칼스, 인코포레이티드 | 디히드록시페닐 신경전달물질 화합물, 조성물 및 방법 |
| EP2918266A1 (en) | 2014-03-11 | 2015-09-16 | CDRD Berolina AB | Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease |
| MX2018004339A (es) | 2015-10-09 | 2019-04-15 | Teva Pharmaceuticals Int Gmbh | Combinación de levodopa deuterado con carbidopa y opicapona para el tratamiento del mal de parkinson. |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3699158A (en) * | 1969-08-25 | 1972-10-17 | Merck & Co Inc | Selective deuteration of tyrosine, aspartic and glutamic acids |
| US3769424A (en) | 1970-10-01 | 1973-10-30 | Merck & Co Inc | Composition and method of treating dopamine deficiency in brain tissue |
| DE2049115C3 (de) | 1970-10-06 | 1981-07-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa) |
| US4663349A (en) | 1985-12-30 | 1987-05-05 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
| DE3779500T2 (de) | 1986-06-10 | 1993-01-21 | Chiesi Farma Spa | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
| JP2718504B2 (ja) * | 1988-02-22 | 1998-02-25 | アローンサクル シャオバニー | 中枢神経系疾患治療法及びアルツハイマー病診断法 |
| IT1226902B (it) | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi del levodopa |
| US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| IL119417A (en) * | 1996-10-13 | 2003-02-12 | Moshe Kushnir | Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease |
| DK0991660T3 (da) | 1997-10-08 | 2006-02-13 | Isotechnika Inc | Deuterede og udeuterede cyclosporinanaloger og deres anvendelse som immunmodulerende midler |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| NO309305B1 (no) | 1999-02-19 | 2001-01-15 | Norsk Hydro As | Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater |
| ATE234299T1 (de) * | 1999-12-03 | 2003-03-15 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel |
| JP2001203263A (ja) | 2000-01-20 | 2001-07-27 | Hitachi Ltd | 半導体集積回路装置の製造方法および半導体集積回路装置 |
| JP2002097137A (ja) | 2000-07-19 | 2002-04-02 | Junichi Sudo | パーキンソン病の予防および／または治療剤 |
| DE10123129A1 (de) | 2001-05-02 | 2002-11-14 | Berolina Drug Dev Ab Svedala | Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel |
| DE10261807A1 (de) | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
-
2002
- 2002-12-19 DE DE10261807A patent/DE10261807A1/de not_active Withdrawn
-
2003
- 2003-12-18 JP JP2004561054A patent/JP2006510686A/ja active Pending
- 2003-12-18 AU AU2003289841A patent/AU2003289841B2/en not_active Ceased
- 2003-12-18 MX MXPA05006408A patent/MXPA05006408A/es active IP Right Grant
- 2003-12-18 CA CA2513088A patent/CA2513088C/en not_active Expired - Fee Related
- 2003-12-18 EA EA200500958A patent/EA009258B1/ru not_active IP Right Cessation
- 2003-12-18 NZ NZ541047A patent/NZ541047A/en not_active IP Right Cessation
- 2003-12-18 US US14/464,444 patent/USRE46629E1/en not_active Expired - Fee Related
- 2003-12-18 DE DE50312224T patent/DE50312224D1/de not_active Expired - Lifetime
- 2003-12-18 EP EP03782168A patent/EP1613571B1/de not_active Expired - Lifetime
- 2003-12-18 AT AT03782168T patent/ATE451340T1/de active
- 2003-12-18 DK DK03782168.3T patent/DK1613571T3/da active
- 2003-12-18 PT PT03782168T patent/PT1613571E/pt unknown
- 2003-12-18 ES ES03782168T patent/ES2337046T3/es not_active Expired - Lifetime
- 2003-12-18 CN CN200380108990A patent/CN100584807C/zh not_active Expired - Fee Related
- 2003-12-18 PL PL377584A patent/PL219269B1/pl unknown
- 2003-12-18 US US10/539,845 patent/US8168820B2/en not_active Ceased
- 2003-12-18 WO PCT/DE2003/004203 patent/WO2004056724A1/de active Application Filing
-
2005
- 2005-06-16 IL IL169203A patent/IL169203A/en active IP Right Grant
-
2006
- 2006-06-07 HK HK06106498.8A patent/HK1086548A1/xx not_active IP Right Cessation
-
2011
- 2011-11-07 JP JP2011243559A patent/JP2012087124A/ja active Pending
-
2015
- 2015-07-03 JP JP2015134445A patent/JP2015212287A/ja not_active Withdrawn
- 2015-07-03 JP JP2015134444A patent/JP2015178537A/ja active Pending
-
2017
- 2017-07-06 JP JP2017132662A patent/JP2018193356A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL377584A1 (pl) | 2006-02-06 |
| MXPA05006408A (es) | 2006-03-08 |
| DE10261807A1 (de) | 2004-07-01 |
| US8168820B2 (en) | 2012-05-01 |
| JP2006510686A (ja) | 2006-03-30 |
| AU2003289841B2 (en) | 2010-01-28 |
| WO2004056724A1 (de) | 2004-07-08 |
| JP2012087124A (ja) | 2012-05-10 |
| JP2015212287A (ja) | 2015-11-26 |
| CA2513088C (en) | 2012-03-06 |
| USRE46629E1 (en) | 2017-12-12 |
| AU2003289841A1 (en) | 2004-07-14 |
| EP1613571A1 (de) | 2006-01-11 |
| PL219269B1 (pl) | 2015-04-30 |
| US20060135615A1 (en) | 2006-06-22 |
| ES2337046T3 (es) | 2010-04-20 |
| NZ541047A (en) | 2008-09-26 |
| HK1086548A1 (en) | 2006-09-22 |
| IL169203A (en) | 2012-05-31 |
| EA200500958A1 (ru) | 2006-02-24 |
| CN100584807C (zh) | 2010-01-27 |
| EP1613571B1 (de) | 2009-12-09 |
| JP2018193356A (ja) | 2018-12-06 |
| DE50312224D1 (de) | 2010-01-21 |
| CN1738782A (zh) | 2006-02-22 |
| PT1613571E (pt) | 2010-02-10 |
| EA009258B1 (ru) | 2007-12-28 |
| JP2015178537A (ja) | 2015-10-08 |
| CA2513088A1 (en) | 2004-07-08 |
| ATE451340T1 (de) | 2009-12-15 |
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