DE10261696A1 - Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base - Google Patents
Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base Download PDFInfo
- Publication number
- DE10261696A1 DE10261696A1 DE2002161696 DE10261696A DE10261696A1 DE 10261696 A1 DE10261696 A1 DE 10261696A1 DE 2002161696 DE2002161696 DE 2002161696 DE 10261696 A DE10261696 A DE 10261696A DE 10261696 A1 DE10261696 A1 DE 10261696A1
- Authority
- DE
- Germany
- Prior art keywords
- matrix
- rotigotine
- matrix polymer
- silicone
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 title claims abstract description 134
- 229960003179 rotigotine Drugs 0.000 title claims abstract description 134
- 239000011159 matrix material Substances 0.000 claims abstract description 154
- 229920000642 polymer Polymers 0.000 claims abstract description 60
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 57
- 239000002245 particle Substances 0.000 claims abstract description 22
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 16
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 6
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 6
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 17
- 239000000853 adhesive Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 8
- 238000011068 loading method Methods 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000002585 base Substances 0.000 description 22
- 239000010410 layer Substances 0.000 description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 14
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 230000004907 flux Effects 0.000 description 10
- 239000013543 active substance Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 8
- 239000002270 dispersing agent Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- -1 ethyl vinyl acetates Chemical class 0.000 description 7
- 239000011241 protective layer Substances 0.000 description 7
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 6
- 238000007792 addition Methods 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 150000002978 peroxides Chemical class 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000012458 free base Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 229920005573 silicon-containing polymer Polymers 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000007970 homogeneous dispersion Substances 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000013464 silicone adhesive Substances 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 229910008051 Si-OH Inorganic materials 0.000 description 1
- 229910006358 Si—OH Inorganic materials 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000008384 inner phase Substances 0.000 description 1
- 229910052909 inorganic silicate Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 150000003097 polyterpenes Chemical class 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 125000005372 silanol group Chemical group 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229920006132 styrene block copolymer Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 229940100640 transdermal system Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2002161696 DE10261696A1 (de) | 2002-12-30 | 2002-12-30 | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| PCT/EP2003/014902 WO2004058247A1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
| EP03789421A EP1490052B1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
| JP2004563207A JP5134187B2 (ja) | 2002-12-30 | 2003-12-24 | ロチゴチン塩基の経皮投与装置 |
| DE50307373T DE50307373D1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
| US10/517,157 US20050175678A1 (en) | 2002-12-30 | 2003-12-24 | Device for the transdermal administration of a rotigotine base |
| CA002485656A CA2485656C (en) | 2002-12-30 | 2003-12-24 | Device for the transdermal administration of a rotigotine base |
| MXPA04012151A MXPA04012151A (es) | 2002-12-30 | 2003-12-24 | Dispositivo para la administracion transdermica de rotigotina base. |
| KR1020047019516A KR100875532B1 (ko) | 2002-12-30 | 2003-12-24 | 로티고틴 염기의 경피투여시스템 |
| PL378243A PL215307B1 (pl) | 2002-12-30 | 2003-12-24 | Matryca do poprzezskórnego aplikowania rotigotyny [(-)-5,6,7,8-tetrahydro-6-[propylo-[2-(2-tienylo)-etylo]-amino-1-naftolu], urzadzenie do poprzezskórnego aplikowania zasady rotigotyny i zastosowanie urzadzenia lub matrycy oraz sposób wytwarzania farmaceutycznej matrycy do poprzezskórnego aplikowania rotigotyny |
| RU2005124166/15A RU2340339C2 (ru) | 2002-12-30 | 2003-12-24 | Устройство для трансдермального введения в организм ротиготина в виде основания |
| HK06108553.6A HK1088227B (en) | 2002-12-30 | 2003-12-24 | Device for the transdermal administration of a rotigotine base |
| BR0311637-9A BR0311637A (pt) | 2002-12-30 | 2003-12-24 | Dispositivo para a administração transdérmica de base de rotigotina |
| AU2003294007A AU2003294007B2 (en) | 2002-12-30 | 2003-12-24 | Device for the transdermal administration of a rotigotine base |
| CN2003801080893A CN1731995B (zh) | 2002-12-30 | 2003-12-24 | 用于经皮给药d2促进素碱的器具 |
| ES03789421T ES2285234T3 (es) | 2002-12-30 | 2003-12-24 | Dispositivo para la administracion transdermica de una base de rotigotina. |
| AT03789421T ATE363274T1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
| SI200330911T SI1490052T1 (sl) | 2002-12-30 | 2003-12-24 | Naprava za transdermalno dajanje rotigotinske baze |
| DK03789421T DK1490052T3 (da) | 2002-12-30 | 2003-12-24 | Indretning til transdermal administration af rotigotinbase |
| PT03789421T PT1490052E (pt) | 2002-12-30 | 2003-12-24 | Dispositivo para administração transdérmica da base da rotigotina. |
| ZA2004/08523A ZA200408523B (en) | 2002-12-30 | 2004-10-21 | System for transdermal administering of rotigotine base |
| IL165131A IL165131A (en) | 2002-12-30 | 2004-11-10 | System for transdermal administering of rotigotine base |
| NO20053202A NO335200B1 (no) | 2002-12-30 | 2005-06-30 | Matriks og innretning for transdermal administrering av rotigotinbase, anvendelse og fremgangsmåte for fremstilling derav. |
| CY20071100977T CY1108084T1 (el) | 2002-12-30 | 2007-07-23 | Συσκευη για τη διαδερμικη χορηγηση ροτιγοτινης-βασης |
| US13/020,414 US8545872B2 (en) | 2002-12-30 | 2011-02-03 | Device for the transdermal administration of a rotigotine base |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2002161696 DE10261696A1 (de) | 2002-12-30 | 2002-12-30 | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10261696A1 true DE10261696A1 (de) | 2004-07-15 |
Family
ID=32519524
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2002161696 Ceased DE10261696A1 (de) | 2002-12-30 | 2002-12-30 | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| DE50307373T Expired - Lifetime DE50307373D1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50307373T Expired - Lifetime DE50307373D1 (de) | 2002-12-30 | 2003-12-24 | Vorrichtung zur transdermalen verabreichung von rotigotin-base |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20050175678A1 (https=) |
| EP (1) | EP1490052B1 (https=) |
| JP (1) | JP5134187B2 (https=) |
| KR (1) | KR100875532B1 (https=) |
| CN (1) | CN1731995B (https=) |
| AT (1) | ATE363274T1 (https=) |
| AU (1) | AU2003294007B2 (https=) |
| BR (1) | BR0311637A (https=) |
| CA (1) | CA2485656C (https=) |
| CY (1) | CY1108084T1 (https=) |
| DE (2) | DE10261696A1 (https=) |
| DK (1) | DK1490052T3 (https=) |
| ES (1) | ES2285234T3 (https=) |
| IL (1) | IL165131A (https=) |
| MX (1) | MXPA04012151A (https=) |
| NO (1) | NO335200B1 (https=) |
| PL (1) | PL215307B1 (https=) |
| PT (1) | PT1490052E (https=) |
| RU (1) | RU2340339C2 (https=) |
| WO (1) | WO2004058247A1 (https=) |
| ZA (1) | ZA200408523B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006054732A1 (de) * | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
| DE102008013123A1 (de) | 2008-03-07 | 2009-09-10 | GM Global Technology Operations, Inc., Detroit | Kopfstütze für einen Kraftfahrzeugsitz mit einem Kleiderbügel |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2959751B2 (ja) | 1995-06-14 | 1999-10-06 | 日産アルティア株式会社 | ホイールドーリー |
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| ATE295726T1 (de) * | 2002-12-02 | 2005-06-15 | Sanol Arznei Schwarz Gmbh | Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese |
| US9102726B2 (en) * | 2002-12-04 | 2015-08-11 | Argos Therapeutics, Inc. | Nucleic acid of recombination expression vector encoding soluble forms of CD83, host cells transformed/transfected therewith and pharmaceutical compositions containing same |
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| DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
| DE10359528A1 (de) * | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
| EP1547592A1 (en) * | 2003-12-23 | 2005-06-29 | Schwarz Pharma Ag | Intranasal formulation of rotigotine |
| DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
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| TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途 |
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| SI2215072T1 (sl) | 2007-11-28 | 2015-10-30 | Ucb Pharma Gmbh | Polimorfna oblika rotigotina |
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- 2003-12-24 DE DE50307373T patent/DE50307373D1/de not_active Expired - Lifetime
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- 2003-12-24 US US10/517,157 patent/US20050175678A1/en not_active Abandoned
- 2003-12-24 EP EP03789421A patent/EP1490052B1/de not_active Expired - Lifetime
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| WO1999049852A1 (de) * | 1998-03-30 | 1999-10-07 | Lts Lohmann Therapie-Systeme Ag | D2-agonist enthaltendes transdermales therapeutisches system zur behandlung des parkinson-syndroms und verfahren zu seiner herstellung |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006054732A1 (de) * | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
| DE102006054732B4 (de) * | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
| US9089527B2 (en) | 2006-11-21 | 2015-07-28 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising ion pair microreservoirs |
| DE102008013123A1 (de) | 2008-03-07 | 2009-09-10 | GM Global Technology Operations, Inc., Detroit | Kopfstütze für einen Kraftfahrzeugsitz mit einem Kleiderbügel |
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