DE10225635C1 - N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung - Google Patents

N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung

Info

Publication number
DE10225635C1
DE10225635C1 DE10225635A DE10225635A DE10225635C1 DE 10225635 C1 DE10225635 C1 DE 10225635C1 DE 10225635 A DE10225635 A DE 10225635A DE 10225635 A DE10225635 A DE 10225635A DE 10225635 C1 DE10225635 C1 DE 10225635C1
Authority
DE
Germany
Prior art keywords
alkyl
alkenyl
coo
cycloalkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE10225635A
Other languages
German (de)
English (en)
Inventor
Karl Schoenafinger
Elisabeth Defossa
Dieter Kadereit
Erich Von Roedern
Thomas Klabunde
Hans-Joerg Burger
Andreas Herling
Karl-Ulrich Wendt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE10225635A priority Critical patent/DE10225635C1/de
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DK03732438T priority patent/DK1513800T3/da
Priority to BR0311646-8A priority patent/BR0311646A/pt
Priority to AU2003238373A priority patent/AU2003238373A1/en
Priority to NZ537004A priority patent/NZ537004A/en
Priority to MXPA04011984A priority patent/MXPA04011984A/es
Priority to CA002488760A priority patent/CA2488760A1/en
Priority to JP2004511258A priority patent/JP4398859B2/ja
Priority to EP03732438A priority patent/EP1513800B1/de
Priority to DE50305693T priority patent/DE50305693D1/de
Priority to AT03732438T priority patent/ATE345326T1/de
Priority to CN038131730A priority patent/CN1659137A/zh
Priority to PCT/EP2003/005355 priority patent/WO2003104188A1/de
Priority to PT03732438T priority patent/PT1513800E/pt
Priority to KR20047019866A priority patent/KR20050004295A/ko
Priority to HR20041161A priority patent/HRPK20041161B3/xx
Priority to PL03372117A priority patent/PL372117A1/xx
Priority to ES03732438T priority patent/ES2277082T3/es
Priority to SI200330635T priority patent/SI1513800T1/sl
Priority to RU2004139122/04A priority patent/RU2004139122A/ru
Priority to TW92115159A priority patent/TW200404763A/zh
Priority to US10/456,570 priority patent/US7049341B2/en
Application granted granted Critical
Publication of DE10225635C1 publication Critical patent/DE10225635C1/de
Priority to ZA200408887A priority patent/ZA200408887B/en
Priority to MA27950A priority patent/MA27232A1/fr
Priority to IL16555804A priority patent/IL165558A0/xx
Priority to IN2747CH2004 priority patent/IN2004CH02747A/en
Priority to NO20050087A priority patent/NO20050087L/no
Priority to CY20071100177T priority patent/CY1106003T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE10225635A 2002-06-07 2002-06-07 N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung Expired - Fee Related DE10225635C1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE10225635A DE10225635C1 (de) 2002-06-07 2002-06-07 N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
HR20041161A HRPK20041161B3 (en) 2002-06-07 2003-05-22 N-benzoylureidocinnamate derivatives, method for production and use thereof
AU2003238373A AU2003238373A1 (en) 2002-06-07 2003-05-22 N-benzoylureidocinnamate derivatives, method for production and use thereof
NZ537004A NZ537004A (en) 2002-06-07 2003-05-22 N-benzoylureidocinnamate derivatives, method for production and use thereof
MXPA04011984A MXPA04011984A (es) 2002-06-07 2003-05-22 Derivados del acido n-benzoil-ureido-cinamico, procedimientos para su preparacion y su uso.
CA002488760A CA2488760A1 (en) 2002-06-07 2003-05-22 N-benzoylureidocinnamate derivatives, method for production and use thereof
JP2004511258A JP4398859B2 (ja) 2002-06-07 2003-05-22 Ｎ−ベンゾイルウレイド桂皮酸誘導体、それらの製造法、およびそれらの使用
EP03732438A EP1513800B1 (de) 2002-06-07 2003-05-22 N-benzoylureido-zimts urederivate, verfahren zu deren herste llung und deren verwendung
DE50305693T DE50305693D1 (de) 2002-06-07 2003-05-22 N-benzoylureido-zimts urederivate, verfahren zu deren herste llung und deren verwendung
AT03732438T ATE345326T1 (de) 2002-06-07 2003-05-22 N-benzoylureido-zimts urederivate, verfahren zu deren herste llung und deren verwendung
CN038131730A CN1659137A (zh) 2002-06-07 2003-05-22 N－苯甲酰基脲基肉桂酸衍生物、其制备方法及其用途
PCT/EP2003/005355 WO2003104188A1 (de) 2002-06-07 2003-05-22 N-benzoylureido-zimtsäurederivate, verfahren zu deren herstellung und deren verwendung
PT03732438T PT1513800E (pt) 2002-06-07 2003-05-22 Derivados de ácido n-benzoilureido-cinâmico, processo para a sua preparação e sua utilização
KR20047019866A KR20050004295A (ko) 2002-06-07 2003-05-22 Ｎ-벤조일우레이도신나메이트 유도체, 이의 제조 방법 및이의 용도
DK03732438T DK1513800T3 (da) 2002-06-07 2003-05-22 Benzoylureido-kanelsyrederivater, fremgangsmåde til deres anvendelse
RU2004139122/04A RU2004139122A (ru) 2002-06-07 2003-05-22 Производные n-бензоилуреидокоричной кислоты, способ их получения и их применение
BR0311646-8A BR0311646A (pt) 2002-06-07 2003-05-22 Derivados de ácido n-benzoilureido cinâmico, processo para sua preparação e seu emprego
SI200330635T SI1513800T1 (sl) 2002-06-07 2003-05-22 N-benzoilureido-cinamatni derivati, postopek za njihovo proizvodnjo in njihova uporaba
ES03732438T ES2277082T3 (es) 2002-06-07 2003-05-22 Derivados del acido n-benzoil-ureido-cinamico, procedimiento para su produccion y su uso.
PL03372117A PL372117A1 (en) 2002-06-07 2003-05-22 N-benzoylureidocinnamate derivatives, method for production and use thereof
TW92115159A TW200404763A (en) 2002-06-07 2003-06-05 N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use
US10/456,570 US7049341B2 (en) 2002-06-07 2003-06-06 N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use
ZA200408887A ZA200408887B (en) 2002-06-07 2004-11-03 N-Benzoylureidocinnamate derivatives, method for production and use thereof.
MA27950A MA27232A1 (fr) 2002-06-07 2004-11-16 Derives d'acide n-benzoylureidocinnamique, leurs procedes de preparation et leurs utilisations
IL16555804A IL165558A0 (en) 2002-06-07 2004-12-05 N-benzoylureidocinnamate derivatives method for production and use thereof
IN2747CH2004 IN2004CH02747A (enExample) 2002-06-07 2004-12-06
NO20050087A NO20050087L (no) 2002-06-07 2005-01-06 N-benzoylureido-kanelsyrederivater, fremgangsmate for fremstilling og anvendelse av disse
CY20071100177T CY1106003T1 (el) 2002-06-07 2007-02-09 Παραγωγα του ν-βενζοϋλοουρεϊδο-κινναμωμικου οξεος, μεθοδος για την παρασκευη τους και η χρηση τους

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10225635A DE10225635C1 (de) 2002-06-07 2002-06-07 N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung

Publications (1)

Publication Number Publication Date
DE10225635C1 true DE10225635C1 (de) 2003-12-24

Family

ID=29594346

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10225635A Expired - Fee Related DE10225635C1 (de) 2002-06-07 2002-06-07 N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
DE50305693T Expired - Lifetime DE50305693D1 (de) 2002-06-07 2003-05-22 N-benzoylureido-zimts urederivate, verfahren zu deren herste llung und deren verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50305693T Expired - Lifetime DE50305693D1 (de) 2002-06-07 2003-05-22 N-benzoylureido-zimts urederivate, verfahren zu deren herste llung und deren verwendung

Country Status (26)

Country Link
EP (1) EP1513800B1 (enExample)
JP (1) JP4398859B2 (enExample)
KR (1) KR20050004295A (enExample)
CN (1) CN1659137A (enExample)
AT (1) ATE345326T1 (enExample)
AU (1) AU2003238373A1 (enExample)
BR (1) BR0311646A (enExample)
CA (1) CA2488760A1 (enExample)
CY (1) CY1106003T1 (enExample)
DE (2) DE10225635C1 (enExample)
DK (1) DK1513800T3 (enExample)
ES (1) ES2277082T3 (enExample)
HR (1) HRPK20041161B3 (enExample)
IL (1) IL165558A0 (enExample)
IN (1) IN2004CH02747A (enExample)
MA (1) MA27232A1 (enExample)
MX (1) MXPA04011984A (enExample)
NO (1) NO20050087L (enExample)
NZ (1) NZ537004A (enExample)
PL (1) PL372117A1 (enExample)
PT (1) PT1513800E (enExample)
RU (1) RU2004139122A (enExample)
SI (1) SI1513800T1 (enExample)
TW (1) TW200404763A (enExample)
WO (1) WO2003104188A1 (enExample)
ZA (1) ZA200408887B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006131482A1 (en) * 2005-06-10 2006-12-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179941B2 (en) 2003-01-23 2007-02-20 Sanofi-Aventis Deutschland Gmbh Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use
DE10302452B4 (de) * 2003-01-23 2005-02-24 Aventis Pharma Deutschland Gmbh Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
DE10306502B4 (de) * 2003-02-17 2005-03-17 Aventis Pharma Deutschland Gmbh Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10335092B3 (de) * 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
US7241787B2 (en) 2004-01-25 2007-07-10 Sanofi-Aventis Deutschland Gmbh Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
EP1586573B1 (en) 2004-04-01 2007-02-07 Sanofi-Aventis Deutschland GmbH Oxadiazolones, processes for their preparation and their use as pharmaceuticals
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006053274A2 (en) 2004-11-15 2006-05-18 Bristol-Myers Squibb Company 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193249A2 (en) * 1985-03-01 1986-09-03 Duphar International Research B.V Benzoyl urea derivatives having ati-tumor activity
EP0632019B1 (en) * 1993-06-28 1997-09-24 Zeneca Limited Acylureas
WO2001094300A1 (de) * 2000-06-09 2001-12-13 Aventis Pharma Deutschland Gmbh Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

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NL141381B (nl) * 1963-09-25 1974-03-15 Hoechst Ag Werkwijze voor het bereiden van geneesmiddelen met bloedsuikerspiegel verlagende werkzaamheid.
ZA867420B (en) * 1985-09-30 1987-05-27 Union Carbide Corp Pesticidal 1-(4-aryloxyphenyl)-3-benzoyl urea compounds and process for preparation
DE4037112A1 (de) * 1990-11-22 1992-05-27 Thomae Gmbh Dr K Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6297269B1 (en) * 1995-06-06 2001-10-02 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
AR028253A1 (es) * 2000-03-16 2003-04-30 Pfizer Prod Inc Inhibidores de la glucogeno fosforilasa
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193249A2 (en) * 1985-03-01 1986-09-03 Duphar International Research B.V Benzoyl urea derivatives having ati-tumor activity
EP0632019B1 (en) * 1993-06-28 1997-09-24 Zeneca Limited Acylureas
WO2001094300A1 (de) * 2000-06-09 2001-12-13 Aventis Pharma Deutschland Gmbh Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chem.Pharm.Bull. 42, S. 57-61 (1994) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006131482A1 (en) * 2005-06-10 2006-12-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents
EA013845B1 (ru) * 2005-06-10 2010-08-30 Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. Производные коричной, фенилпропиоловой и фенилпропановой кислот, пригодные для использования в качестве противоопухолевых средств
US7816386B2 (en) 2005-06-10 2010-10-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents

Also Published As

Publication number Publication date
RU2004139122A (ru) 2005-06-10
DK1513800T3 (da) 2007-03-26
ZA200408887B (en) 2005-11-23
MXPA04011984A (es) 2005-03-07
CY1106003T1 (el) 2011-04-06
DE50305693D1 (de) 2006-12-28
KR20050004295A (ko) 2005-01-12
WO2003104188A1 (de) 2003-12-18
SI1513800T1 (sl) 2007-04-30
PT1513800E (pt) 2007-02-28
MA27232A1 (fr) 2005-02-01
NZ537004A (en) 2006-06-30
EP1513800B1 (de) 2006-11-15
IN2004CH02747A (enExample) 2006-02-10
JP4398859B2 (ja) 2010-01-13
TW200404763A (en) 2004-04-01
CA2488760A1 (en) 2003-12-18
HRPK20041161B3 (en) 2006-09-30
CN1659137A (zh) 2005-08-24
IL165558A0 (en) 2006-01-15
NO20050087L (no) 2005-01-06
EP1513800A1 (de) 2005-03-16
BR0311646A (pt) 2005-03-15
AU2003238373A1 (en) 2003-12-22
ES2277082T3 (es) 2007-07-01
PL372117A1 (en) 2005-07-11
ATE345326T1 (de) 2006-12-15
HRP20041161A2 (en) 2005-04-30
JP2005529164A (ja) 2005-09-29

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
8304 Grant after examination procedure
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20130101