DE102017114737A1 - Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie - Google Patents

Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie Download PDF

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Publication number
DE102017114737A1
DE102017114737A1 DE102017114737.3A DE102017114737A DE102017114737A1 DE 102017114737 A1 DE102017114737 A1 DE 102017114737A1 DE 102017114737 A DE102017114737 A DE 102017114737A DE 102017114737 A1 DE102017114737 A1 DE 102017114737A1
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Germany
Prior art keywords
seq
tcr
antigen
chain
amino acid
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Withdrawn
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DE102017114737.3A
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German (de)
English (en)
Inventor
Claudia Wagner
Leonie ALTEN
Sebastian Bunk
Dominik Maurer
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Immatics Biotechnologies GmbH
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Immatics Biotechnologies GmbH
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Priority to DE102017114737.3A priority Critical patent/DE102017114737A1/de
Priority to SG11201911437VA priority patent/SG11201911437VA/en
Priority to EP18737546.4A priority patent/EP3645573B1/en
Priority to KR1020197036902A priority patent/KR20200023288A/ko
Priority to CN201880033171.0A priority patent/CN110753705A/zh
Priority to BR112019025323-8A priority patent/BR112019025323A2/pt
Priority to JP2019569676A priority patent/JP7235316B2/ja
Priority to AU2018293322A priority patent/AU2018293322A1/en
Priority to MA049503A priority patent/MA49503A/fr
Priority to CR20190594A priority patent/CR20190594A/es
Priority to TW107122290A priority patent/TWI727182B/zh
Priority to CA3067757A priority patent/CA3067757A1/en
Priority to MYPI2019007601A priority patent/MY205262A/en
Priority to PE2019002620A priority patent/PE20200337A1/es
Priority to PH1/2019/502847A priority patent/PH12019502847A1/en
Priority to PCT/EP2018/067380 priority patent/WO2019002444A1/en
Priority to MX2019015742A priority patent/MX2019015742A/es
Priority to ARP180101832 priority patent/AR112604A1/es
Priority to US16/023,731 priority patent/US10590194B2/en
Publication of DE102017114737A1 publication Critical patent/DE102017114737A1/de
Priority to US16/403,269 priority patent/US10723796B2/en
Priority to CL2019003885A priority patent/CL2019003885A1/es
Priority to IL271751A priority patent/IL271751A/en
Priority to US16/733,845 priority patent/US11111294B2/en
Priority to CONC2020/0000357A priority patent/CO2020000357A2/es
Priority to US17/397,656 priority patent/US20210388079A1/en
Priority to US18/916,878 priority patent/US20250154246A1/en
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8135Kazal type inhibitors, e.g. pancreatic secretory inhibitor, ovomucoid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE102017114737.3A 2017-06-30 2017-06-30 Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie Withdrawn DE102017114737A1 (de)

Priority Applications (26)

Application Number Priority Date Filing Date Title
DE102017114737.3A DE102017114737A1 (de) 2017-06-30 2017-06-30 Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
PH1/2019/502847A PH12019502847A1 (en) 2017-06-30 2018-06-28 Novel t cell receptors and immune therapy using the same
PE2019002620A PE20200337A1 (es) 2017-06-30 2018-06-28 Receptores de celulas t novedosos, e inmunoterapia usando los mismos
KR1020197036902A KR20200023288A (ko) 2017-06-30 2018-06-28 신규 t 세포 수용체 및 이를 사용하는 면역 요법
CN201880033171.0A CN110753705A (zh) 2017-06-30 2018-06-28 新型t细胞受体及其免疫治疗
BR112019025323-8A BR112019025323A2 (pt) 2017-06-30 2018-06-28 Receptores de células t e imunoterapia empregando os mesmos
JP2019569676A JP7235316B2 (ja) 2017-06-30 2018-06-28 新規t細胞受容体およびそれを用いた免疫療法
AU2018293322A AU2018293322A1 (en) 2017-06-30 2018-06-28 Novel T cell receptors and immune therapy using the same
MA049503A MA49503A (fr) 2017-06-30 2018-06-28 Nouveaux récepteurs de lymphocytes t et immunothérapie les utilisant
CR20190594A CR20190594A (es) 2017-06-30 2018-06-28 Receptores de células t novedosos, e inmunoterapia usando los mismos
EP18737546.4A EP3645573B1 (en) 2017-06-30 2018-06-28 Novel t cell receptors and immune therapy using the same
CA3067757A CA3067757A1 (en) 2017-06-30 2018-06-28 Novel t cell receptors and immune therapy using the same
PCT/EP2018/067380 WO2019002444A1 (en) 2017-06-30 2018-06-28 NEW T CELL RECEPTORS AND IMMUNOTHERAPY USING THE SAME
SG11201911437VA SG11201911437VA (en) 2017-06-30 2018-06-28 Novel t cell receptors and immune therapy using the same
TW107122290A TWI727182B (zh) 2017-06-30 2018-06-28 新型t細胞受體及其免疫治療
MYPI2019007601A MY205262A (en) 2017-06-30 2018-06-28 Novel t cell receptors and immune therapy using the same
MX2019015742A MX2019015742A (es) 2017-06-30 2018-06-28 Receptores de celulas t novedosos, e inmunoterapia usando los mismos.
ARP180101832 AR112604A1 (es) 2017-06-30 2018-06-29 Receptores de células t, e inmunoterapia usando los mismos
US16/023,731 US10590194B2 (en) 2017-06-30 2018-06-29 T cell receptors and immune therapy using the same
US16/403,269 US10723796B2 (en) 2017-06-30 2019-05-03 T cell receptors and immune therapy using the same
CL2019003885A CL2019003885A1 (es) 2017-06-30 2019-12-27 Receptores de células t novedosos, e inmunoterapia usando los mismos.
IL271751A IL271751A (en) 2017-06-30 2019-12-29 T cell receptors and immunotherapy using them
US16/733,845 US11111294B2 (en) 2017-06-30 2020-01-03 T cell receptors and immune therapy using the same
CONC2020/0000357A CO2020000357A2 (es) 2017-06-30 2020-01-14 Receptores de células t novedosos, e inmunoterapia usando los mismos
US17/397,656 US20210388079A1 (en) 2017-06-30 2021-08-09 Novel t cell receptors and immune therapy using the same
US18/916,878 US20250154246A1 (en) 2017-06-30 2024-10-16 Novel t cell receptors and immune therapy using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102017114737.3A DE102017114737A1 (de) 2017-06-30 2017-06-30 Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie

Publications (1)

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DE102017114737A1 true DE102017114737A1 (de) 2019-01-03

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DE102017114737.3A Withdrawn DE102017114737A1 (de) 2017-06-30 2017-06-30 Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie

Country Status (22)

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US (5) US10590194B2 (enExample)
EP (1) EP3645573B1 (enExample)
JP (1) JP7235316B2 (enExample)
KR (1) KR20200023288A (enExample)
CN (1) CN110753705A (enExample)
AR (1) AR112604A1 (enExample)
AU (1) AU2018293322A1 (enExample)
BR (1) BR112019025323A2 (enExample)
CA (1) CA3067757A1 (enExample)
CL (1) CL2019003885A1 (enExample)
CO (1) CO2020000357A2 (enExample)
CR (1) CR20190594A (enExample)
DE (1) DE102017114737A1 (enExample)
IL (1) IL271751A (enExample)
MA (1) MA49503A (enExample)
MX (1) MX2019015742A (enExample)
MY (1) MY205262A (enExample)
PE (1) PE20200337A1 (enExample)
PH (1) PH12019502847A1 (enExample)
SG (1) SG11201911437VA (enExample)
TW (1) TWI727182B (enExample)
WO (1) WO2019002444A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025006196A1 (en) * 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1255541A1 (zh) 2015-12-11 2019-08-23 Immatics Biotechnologies Gmbh 用於多种癌症免疫治疗的新型肽和肽组合物
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
DE102019108125B4 (de) 2019-03-28 2022-02-03 Immatics US, Inc. Cd28 t-zellkulturen, zusammensetzungen und verfahren zu deren verwendung
US20200297768A1 (en) 2019-03-19 2020-09-24 Immatics US, Inc. Cd28 t cell cultures, compositions, and methods of using thereof
PE20220164A1 (es) 2019-05-27 2022-01-28 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas
US20210032370A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Recruiting agent further binding an mhc molecule
CN112442119B (zh) * 2019-09-05 2023-02-24 香雪生命科学技术(广东)有限公司 一种识别ssx2的高亲和力t细胞受体
BR112022016909A2 (pt) 2020-02-24 2022-12-06 Immatics Us Inc Métodos para a expansão de células t para o tratamento de câncer e malignidades associadas
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20220056411A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
DE102021100038A1 (de) 2020-12-31 2022-06-30 Immatics US, Inc. Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung
JP2024502034A (ja) 2020-12-31 2024-01-17 イマティクス ユーエス,アイエヌシー. Cd8ポリペプチド、組成物、及びそれらの使用方法
MX2023012899A (es) 2021-05-05 2023-11-08 Immatics Biotechnologies Gmbh Polipeptidos de union a antigeno bma031 mejorados.
US20230089392A1 (en) 2021-09-20 2023-03-23 Immatics US, Inc. Monocyte depletion of t cells populations for t-cell therapy
WO2023081461A1 (en) 2021-11-08 2023-05-11 Immatics US, Inc. Methods for generating cell spheroids
US20240066127A1 (en) 2022-04-28 2024-02-29 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
JP2025515604A (ja) 2022-04-28 2025-05-20 イマティクス ユーエス,アイエヌシー. ドミナントネガティブTGFβ受容体ポリペプチド、CD8ポリペプチド、細胞、組成物、およびその使用方法
EP4514829A1 (en) 2022-04-28 2025-03-05 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
EP4519418A1 (en) 2022-05-05 2025-03-12 Immatics US, Inc. Methods for improving t cell efficacy
WO2025096649A1 (en) 2023-11-01 2025-05-08 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5569825A (en) 1990-08-29 1996-10-29 Genpharm International Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US20020197266A1 (en) 2000-02-08 2002-12-26 Waldemar Debinski Immunotherapy using interleukin 13 receptor subunit alpha 2

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5244499A (en) * 1998-07-31 2000-02-21 Diagnostic Products Corporation Polynucleotide encoding an autoantigen associated with endometriosis
GB0525999D0 (en) * 2005-12-21 2006-02-01 Ares Trading Sa Novel members of the kazal family of serine protease inhibitors
EP2116596A4 (en) * 2007-03-05 2010-04-07 Int Inst Cancer Immunology Inc L-CELL RECEPTOR GENE SPECIFIC TO A CANCER ANTIGEN, PEPTIDE CODED BY THE GENE AND THEIR USE
WO2014024914A1 (ja) * 2012-08-08 2014-02-13 第一三共株式会社 ペプチド・ライブラリー及びその利用
CN110511960B (zh) * 2013-07-15 2023-05-23 美国卫生和人力服务部 抗人乳头瘤病毒16 e6 t细胞受体
GB201314404D0 (en) * 2013-08-12 2013-09-25 Immunocore Ltd T Cell Receptors
AU2015342964B2 (en) * 2014-11-05 2021-06-24 Genentech, Inc. Methods of producing two chain proteins in bacteria
EP3156067A1 (en) * 2015-10-16 2017-04-19 Max-Delbrück-Centrum Für Molekulare Medizin High avidity hpv t-cell receptors
GB201520597D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520567D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201521894D0 (en) 2015-12-11 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various cancers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5569825A (en) 1990-08-29 1996-10-29 Genpharm International Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US20020197266A1 (en) 2000-02-08 2002-12-26 Waldemar Debinski Immunotherapy using interleukin 13 receptor subunit alpha 2

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
1. Internet Recherche vom 20.03.2018 www.ncbi.nlm.nih.gov/protein NP_001258647 *
2. K. E. TILLER und P. M. TESSIER: Advances in antibody design. 2015. Annual review of biomedical engineering, Vol. 17, S. 191-216 *
C.A. Janeway et al. (eds.), Immunobiology, 8 Ed., Garland Publishing, New York, NY (201 1)
Harlow and Lane (eds.), Antibodies: A Laboratory Manual, CSH Press (1988)
Haskard and Archer, J. Immunol. Methods, 74(2), 361-67 (1984), und Roder et al, Methods Enzymol, 121, 140-67 (1986)
Huse et al., Science, 246, 1275-81 (1989)
Kohler and Milstein, Eur. J. Immunol, 5, 51 1-519 (1976)

Cited By (1)

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WO2025006196A1 (en) * 2023-06-28 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation

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