BR112022016909A2 - Métodos para a expansão de células t para o tratamento de câncer e malignidades associadas - Google Patents

Métodos para a expansão de células t para o tratamento de câncer e malignidades associadas

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Publication number
BR112022016909A2
BR112022016909A2 BR112022016909A BR112022016909A BR112022016909A2 BR 112022016909 A2 BR112022016909 A2 BR 112022016909A2 BR 112022016909 A BR112022016909 A BR 112022016909A BR 112022016909 A BR112022016909 A BR 112022016909A BR 112022016909 A2 BR112022016909 A2 BR 112022016909A2
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Brazil
Prior art keywords
methods
cells
cancer
treatment
cell expansion
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BR112022016909A
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English (en)
Inventor
MATA Melinda
Kalra Mamta
Mohamed Ali
Walter Steffen
BULLIARD Yannick
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Immatics Us Inc
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Publication date
Application filed by Immatics Us Inc filed Critical Immatics Us Inc
Publication of BR112022016909A2 publication Critical patent/BR112022016909A2/pt

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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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Abstract

MÉTODOS PARA A EXPANSÃO DE CÉLULAS T PARA O TRATAMENTO DE CÂNCER E MALIGNIDADES ASSOCIADAS. Um método in vitro de expansão de células T ?d , o qual inclui isolar células T ?d de uma amostra de sangue de um sujeito humano, ativar as células T ?d isoladas na presença de um aminobifosfonato e/ou uma célula alimentadora e pelo menos uma citocina, expandir as células T ?d ativadas e, opcionalmente, reestimular as células T ?d expandidas.
BR112022016909A 2020-02-24 2021-02-23 Métodos para a expansão de células t para o tratamento de câncer e malignidades associadas BR112022016909A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062980844P 2020-02-24 2020-02-24
US202063038008P 2020-06-11 2020-06-11
US202063082881P 2020-09-24 2020-09-24
PCT/US2021/019252 WO2021173560A1 (en) 2020-02-24 2021-02-23 Methods for expanding t cells for the treatment of cancer and related malignancies

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BR112022016909A2 true BR112022016909A2 (pt) 2022-12-06

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Country Link
EP (1) EP4110901A1 (pt)
JP (1) JP2023515131A (pt)
KR (1) KR20230012465A (pt)
CN (1) CN115427554A (pt)
AU (1) AU2021225817A1 (pt)
BR (1) BR112022016909A2 (pt)
CA (1) CA3168729A1 (pt)
IL (1) IL295891A (pt)
MX (1) MX2022010461A (pt)
TW (1) TW202146645A (pt)
WO (1) WO2021173560A1 (pt)

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DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
DE102016123847B3 (de) 2016-12-08 2018-04-05 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
US11629333B2 (en) * 2017-02-08 2023-04-18 Agency For Science, Technology And Research Gamma delta T cells and a method of augmenting the tumoricidal activity of the same
DE102017106305A1 (de) 2017-03-23 2018-09-27 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapien gegen prame-positive Krebsarten
US11236145B2 (en) 2017-03-23 2022-02-01 Immatics Biotechnologies Gmbh T cell receptors and immune therapy using the same against PRAME positive cancers
DE102017114737A1 (de) 2017-06-30 2019-01-03 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
PE20200614A1 (es) 2017-07-14 2020-03-11 Immatics Biotechnologies Gmbh Molecula de polipeptido con especificidad dual mejorada
GB201715918D0 (en) * 2017-09-29 2017-11-15 Tc Biopharm Ltd Modified CAR-T
WO2019086665A1 (en) 2017-11-06 2019-05-09 Immatics Biotechnologies Gmbh Novel engineered t cell receptors and immune therapy using the same
DE102017127984B4 (de) * 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
DE102018122546B3 (de) 2018-09-14 2019-12-05 Immatics Biotechnologies Gmbh Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden
CN109234236A (zh) * 2018-09-29 2019-01-18 吉林大学第医院 一种嵌合抗原受体γδT细胞的制备方法
US20200384028A1 (en) 2019-06-06 2020-12-10 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides

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MX2022010461A (es) 2022-12-13
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